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Sökning: (WFRF:(Blimark Cecilie)) > Secondary immunodef...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003404naa a2200457 4500
001oai:gup.ub.gu.se/247741
003SwePub
008240528s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134705118
024a https://gup.ub.gu.se/publication/2477412 URI
024a https://doi.org/10.1002/hon.23232 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1347051182 URI
040 a (SwePub)gud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Friman, Vanda,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xfriva
2451 0a Secondary immunodeficiency in lymphoproliferative malignancies
264 c 2016-07-12
264 1b Wiley,c 2016
520 a Secondary immunodeficiencies occur as a consequence of various diseases, including hematological malignancies, and the use of pharmacological therapies, such as immunosuppressive, anti-inflammatory, and biological drugs. Infections are the main cause of morbidity and mortality in multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients. Recent advances in treatment have prolonged the duration of remission and the time between relapse phases in MM and CLL patients. However, managing multiple relapses and the use of salvage therapies can lead to cumulative immunosuppression and a higher risk of infections. The pathogenesis of immune deficiency secondary to lymphoproliferative malignancy is multifactorial including disease- and treatment-related factors. Supportive treatment, including early vaccination, anti-infective prophylaxis, and replacement immunoglobulin, plays a key role in preventing infections in MM and CLL. This article provides an overview of the basic immunology necessary to understand the pathogenesis of secondary immunodeficiency and the infectious complications in MM and CLL. We also discuss the evidence supporting the role of prophylactic replacement immunoglobulin treatment in patients with antibody failure secondary to MM and CLL and the indications for its use. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a chronic lymphocytic leukemia
653 a infections
653 a multiple myeloma
653 a prophylaxis
653 a replacement immunoglobulin
653 a secondary immunodeficiencies
653 a supportive therapy
700a Winqvist, O.u Karolinska Institutet4 aut
700a Blimark, Cecilie4 aut
700a Langerbeins, P.4 aut
700a Chapel, H.4 aut
700a Dhalla, F.4 aut
710a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org
773t Hematological Oncologyd : Wileyg 34:3, s. 121-132q 34:3<121-132x 0278-0232x 1099-1069
8564 8u https://gup.ub.gu.se/publication/247741
8564 8u https://doi.org/10.1002/hon.2323
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134705118

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