(WFRF:(Brun R)) srt2:(1992-1994)
Search: (WFRF:(Brun R)) srt2:(1992-1994) > Enhanced boron upta...
- 6 of 8
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03101naa a2200289 4500 | |
| 001 | oai:lup.lub.lu.se:3989e1b3-ddc2-4b8b-a270-5b853cdc820e | |
| 003 | SwePub | |
| 008 | 160401s1994 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11083742 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Ceberg, Cristeru Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)rafy-cce |
| 245 | 1 0 | a Enhanced boron uptake in RG 2 rat gliomas by electropermeabilization in vivo--a new possibility in boron neutron capture therapy |
| 264 | 1 | c 1994 |
| 520 | a Accumulation of boron in tumor tissue is an indispensable requirement for boron neutron capture therapy and it is important that the uptake is as high as possible. In this work we have studied the influence of electropermeabilization in vivo on the uptake of boron in normal and RG 2 glioma bearing Fischer 344 rats. Two different boron compounds, a sulfhydryl boron hydride (BSH) and a boronated porphyrin (BOPP), have been investigated. The rats were infused intravenously during 5 min with 175 micrograms BSH/g body weight or 12 micrograms BOPP/g body weight. Two electrodes were placed 5 mm apart in the brain and electropermeabilization was performed with eight square 400 V pulses at 4 and 7 min after the end of the infusion. After 6 h the animals were killed, and the boron content in the tumors and the surrounding brain was measured with neutron-activated autoradiography. In electropermeabilized healthy animals the BOPP uptake was low and limited to the electrode lesions, whereas BSH was spread extensively throughout the hemisphere. Rats with gliomas showed doubled (BOPP) to 10-fold (BSH) uptake of boron in the tumor when electropermeabilization was performed as compared with untreated animals. We conclude that electropermeabilization in the future may provide an interesting possibility to increase the uptake of certain boron compounds before neutron capture therapy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 700 | 1 | a Brun, A4 aut |
| 700 | 1 | a Mir, L M4 aut |
| 700 | 1 | a Persson, Bertil Ru Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)radf-bpe |
| 700 | 1 | a Salford, L G4 aut |
| 710 | 2 | a Medicinsk strålningsfysik, Lundb Sektion V4 org |
| 773 | 0 | t Anti-Cancer Drugsg 5:4, s. 463-466q 5:4<463-466x 0959-4973 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1108374 |
Find in a library
- Anti-Cancer Drugs (Search for host publication in LIBRIS)
To the university's database
- 6 of 8
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ceberg, Crister
- Brun, A
- Mir, L M
- Persson, Bertil ...
- Salford, L G
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Radiology Nuclea ...
- Articles in the publication
- Anti-Cancer Drug ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
