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Sökning: (WFRF:(Bueno de Mesquita H. Bas)) pers:(Sanchez Maria Jose) > (2020-2022) > Development and val...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009603naa a2200949 4500
001oai:lup.lub.lu.se:c74fe4ee-ccb6-4073-98cd-6ec6e0579091
003SwePub
008210112s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-178982
0247 a https://lup.lub.lu.se/record/c74fe4ee-ccb6-4073-98cd-6ec6e05790912 URI
0247 a https://doi.org/10.1186/s12916-020-01826-02 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1789822 URI
040 a (SwePub)lud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Aleksandrova, Krasimirau Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH,German Institute of Human Nutrition,University of Potsdam4 aut
2451 0a Development and validation of a lifestyle-based model for colorectal cancer risk prediction : the LiFeCRC score
264 c 2021-01-04
264 1b Springer Science and Business Media LLC,c 2021
520 a Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to screening and motivate behaviour change. We therefore developed and validated a lifestyle-based CRC risk prediction algorithm in an asymptomatic European population. Methods: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. The model was validated in a sample comprising 74,403 participants selected among five EPIC centres. Over a median follow-up time of 15 years, there were 3645 and 981 colorectal cancer cases in the derivation and validation samples, respectively. Variable selection algorithms in Cox proportional hazard regression and random survival forest (RSF) were used to identify the best predictors among plausible predictor variables. Measures of discrimination and calibration were calculated in derivation and validation samples. To facilitate model communication, a nomogram and a web-based application were developed. Results: The final selection model included age, waist circumference, height, smoking, alcohol consumption, physical activity, vegetables, dairy products, processed meat, and sugar and confectionary. The risk score demonstrated good discrimination overall and in sex-specific models. Harrell’s C-index was 0.710 in the derivation cohort and 0.714 in the validation cohort. The model was well calibrated and showed strong agreement between predicted and observed risk. Random survival forest analysis suggested high model robustness. Beyond age, lifestyle data led to improved model performance overall (continuous net reclassification improvement = 0.307 (95% CI 0.264–0.352)), and especially for young individuals below 45 years (continuous net reclassification improvement = 0.364 (95% CI 0.084–0.575)). Conclusions: LiFeCRC score based on age and lifestyle data accurately identifies individuals at risk for incident colorectal cancer in European populations and could contribute to improved prevention through motivating lifestyle change at an individual level.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Cancer prevention
653 a Colorectal cancer
653 a Lifestyle behaviour
653 a Risk prediction
653 a Risk screening
653 a Colorectal cancer
7001 a Reichmann, Robinu University of Potsdam,German Institute of Human Nutrition4 aut
7001 a Kaaks, Rudolfu German Cancer Research Centre4 aut
7001 a Jenab, Mazdau International Agency for Research on Cancer, World Health Organization,Imperial College London4 aut
7001 a Bueno-de-Mesquita, H. Basu National Institute for Public Health and the Environment (RIVM),Imperial College London4 aut
7001 a Dahm, Christina C.u Aarhus University4 aut
7001 a Eriksen, Anne Kirstineu Danish Cancer Society4 aut
7001 a Tjønneland, Anneu Danish Cancer Society4 aut
7001 a Artaud, Fannyu Institut Gustave Roussy,University of Paris-Saclay4 aut
7001 a Boutron-Ruault, Marie Christineu Institut Gustave Roussy,University of Paris-Saclay4 aut
7001 a Severi, Gianlucau Institut Gustave Roussy,University of Paris-Saclay,University of Florence4 aut
7001 a Hüsing, Anikau German Cancer Research Centre4 aut
7001 a Trichopoulou, Antoniau Hellenic Health Foundation, Athens4 aut
7001 a Karakatsani, Annau National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens4 aut
7001 a Peppa, Eleniu Hellenic Health Foundation, Athens4 aut
7001 a Panico, Salvatoreu University of Naples Federico II4 aut
7001 a Masala, Giovannau Institute for Cancer Research, Prevention and Clinical Network (ISPRO)4 aut
7001 a Grioni, Sarau Istituto Nazionale dei Tumori4 aut
7001 a Sacerdote, Carlottau Citta' della Salute e della Scienza Hospital-University of Turin4 aut
7001 a Tumino, Rosariou Provincial Health Authority (ASP) Ragusa4 aut
7001 a Elias, Sjoerd G.u University Medical Center Utrecht,Utrecht University4 aut
7001 a May, Anne M.u University Medical Center Utrecht,Utrecht University4 aut
7001 a Borch, Kristin B.u UiT The Arctic University of Norway, Tromsø4 aut
7001 a Sandanger, Torkjel M.u UiT The Arctic University of Norway, Tromsø4 aut
7001 a Skeie, Guriu UiT The Arctic University of Norway, Tromsø4 aut
7001 a Sánchez, Maria Joseu CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada4 aut
7001 a Huerta, José Maríau CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council4 aut
7001 a Sala, Núriau Bellvitge Biomedical Research Institute,Catalan Institute of Oncology4 aut
7001 a Gurrea, Aurelio Barricarteu Health Research Institute of Navarra (IDISNA),Navarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Quirós, José Ramónu Public Health Directorate4 aut
7001 a Amiano, Pilaru Basque Regional Health Department,CIBER Epidemiology and Public Health (CIBERESP),Biodonostia Health Research Institute4 aut
7001 a Berntsson, Jonnau Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Personalized Pathology & Cancer Therapy,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)jo6056be
7001 a Drake, Isabelu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Diabetes - Cardiovascular Disease,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)med-ihm
7001 a van Guelpen, Bethanyu Umeå universitet,Umeå University,Onkologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)4 aut0 (Swepub:umu)beyvan99
7001 a Harlid, Sophiau Umeå universitet,Umeå University,Onkologi4 aut0 (Swepub:umu)soha0105
7001 a Key, Timu University of Oxford4 aut
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Aglago, Elom K.u International Agency for Research on Cancer, World Health Organization4 aut
7001 a Cross, Amanda J.u Imperial College London4 aut
7001 a Tsilidis, Konstantinos K.u University of Ioannina,Imperial College London4 aut
7001 a Riboli, Eliou Imperial College London4 aut
7001 a Gunter, Marc J.u International Agency for Research on Cancer, World Health Organization4 aut
7102 a Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbHb German Institute of Human Nutrition4 org
7730 t BMC Medicined : Springer Science and Business Media LLCg 19:1q 19:1x 1741-7015
8564 u http://dx.doi.org/10.1186/s12916-020-01826-0x freey FULLTEXT
8564 u https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-020-01826-0
8564 u https://doi.org/10.1186/s12916-020-01826-0y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1526024/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/c74fe4ee-ccb6-4073-98cd-6ec6e0579091
8564 8u https://doi.org/10.1186/s12916-020-01826-0
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178982

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