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Long-term Follow-up...
Long-term Follow-up of 84 Patients With Giant Prolactinomas-A Swedish Nationwide Study.
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- Himonakos, Christos (författare)
- Karolinska Institute,Karlstad Hospital
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- Burman, Pia (författare)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Borg, Henrik (författare)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Dahlqvist, Per (författare)
- Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden
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- Engström, Britt Edén (författare)
- Department of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University and Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Ekman, Bertil (författare)
- Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
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- Emilsson, Louise (författare)
- Karolinska Institutet,Karolinska Institute,University of Oslo
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- Olsson, Daniel S, 1983 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; AstraZeneca, Sweden
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- Ragnarsson, Oskar, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Wahlberg, Jeanette, 1969- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Sweden,Orebro Univ Hosp, Sweden; Orebro Univ, Sweden
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- Åkerman, Anna-Karin (författare)
- Karolinska Institute,Örebro University Hospital
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- Höybye, Charlotte (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Berinder, Katarina (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- Oxford University Press, 2023
- 2023
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : Oxford University Press. - 1945-7197 .- 0021-972X. ; 108:12
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Abstract
Ämnesord
Stäng
- To describe the clinical presentation and treatment outcomes in a nationwide cohort of patients with giant prolactinomas.Register-based study of patients with giant prolactinomas [serum prolactin (PRL) > 1000 µg/L, tumor diameter ≥40 mm] identified in the Swedish Pituitary Register 1991-2018.Eighty-four patients [mean age 47 (SD ±16) years, 89% men] were included in the study. At diagnosis, the median PRL was 6305 µg/L (range 1450-253 000), the median tumor diameter was 47 mm (range 40-85), 84% of the patients had hypogonadotropic hypogonadism, and 71% visual field defects. All patients were treated with a dopamine agonist (DA) at some point. Twenty-three (27%) received 1 or more additional therapies, including surgery (n = 19), radiotherapy (n = 6), other medical treatments (n = 4), and chemotherapy (n = 2). Ki-67 was ≥10% in 4/14 tumors. At the last follow-up [median 9 years (interquartile range (IQR) 4-15)], the median PRL was 12 µg/L (IQR 4-126), and the median tumor diameter was 22 mm (IQR 3-40). Normalized PRL was achieved in 55%, significant tumor reduction in 69%, and combined response (normalized PRL and significant tumor reduction) in 43%. In the primary DA-treated patients (n = 79), the reduction in PRL or tumor size after the first year predicted the combined response at the last follow-up (P < .001 and P = .012, respectively).DAs effectively reduced PRL and tumor size, but approximately 1 patient out of 4 needed multimodal treatment. Our results suggest that the response to DA after 1 year is useful for identifying patients who need more careful monitoring and, in some cases, additional treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Male
- Humans
- Middle Aged
- Female
- Prolactinoma
- drug therapy
- pathology
- Pituitary Neoplasms
- therapy
- drug therapy
- Follow-Up Studies
- Sweden
- epidemiology
- Prolactin
- Dopamine Agonists
- therapeutic use
- giant prolactinomas
- dopamine agonist resistance
- dopamine agonists
- giant prolactinomas
- Ki-67
- long-term follow-up
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Himonakos, Chris ...
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Burman, Pia
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Borg, Henrik
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Dahlqvist, Per
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Engström, Britt ...
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Ekman, Bertil
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Emilsson, Louise
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Olsson, Daniel S ...
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Ragnarsson, Oska ...
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Wahlberg, Jeanet ...
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Åkerman, Anna-Ka ...
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Höybye, Charlott ...
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Berinder, Katari ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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The Journal of c ...
- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Umeå universitet
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Linköpings universitet
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Lunds universitet
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Karolinska Institutet