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FältnamnIndikatorerMetadata
00005034naa a2200673 4500
001oai:gup.ub.gu.se/190426
003SwePub
008240528s2014 | |||||||||||000 ||eng|
009oai:research.chalmers.se:a4faba18-e3ca-4c4c-a491-959f72e9543d
0247 a https://gup.ub.gu.se/publication/1904262 URI
0247 a https://doi.org/10.1002/jbmr.20172 DOI
0247 a https://research.chalmers.se/publication/1904262 URI
040 a (SwePub)gud (SwePub)cth
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Johansson, Helena,d 1981u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,University of Gothenburg4 aut0 (Swepub:gu)xjhell
2451 0a A meta-analysis of the association of fracture risk and body mass index in women.
264 c 2013-12-19
264 1b Wiley,c 2014
520 a Several recent studies suggest that obesity may be a risk factor for fracture. The aim of this study was to investigate the association between body mass index (BMI) and future fracture risk at different skeletal sites. In prospective cohorts from more than 25 countries, baseline data on BMI were available in 398,610 women with an average age of 63 (range, 20-105) years and follow up of 2.2 million person-years during which 30,280 osteoporotic fractures (6457 hip fractures) occurred. Femoral neck BMD was measured in 108,267 of these women. Obesity (BMI ≥ 30kg/m(2) ) was present in 22%. A majority of osteoporotic fractures (81%) and hip fractures (87%) arose in non-obese women. Compared to a BMI of 25kg/m(2) , the hazard ratio (HR) for osteoporotic fracture at a BMI of 35kg/m(2) was 0.87 (95% confidence interval [CI], 0.85-0.90). When adjusted for bone mineral density (BMD), however, the same comparison showed that the HR for osteoporotic fracture was increased (HR, 1.16; 95% CI, 1.09-1.23). Low BMI is a risk factor for hip and all osteoporotic fracture, but is a protective factor for lower leg fracture, whereas high BMI is a risk factor for upper arm (humerus and elbow) fracture. When adjusted for BMD, low BMI remained a risk factor for hip fracture but was protective for osteoporotic fracture, tibia and fibula fracture, distal forearm fracture, and upper arm fracture. When adjusted for BMD, high BMI remained a risk factor for upper arm fracture but was also a risk factor for all osteoporotic fractures. The association between BMI and fracture risk is complex, differs across skeletal sites, and is modified by the interaction between BMI and BMD. At a population level, high BMI remains a protective factor for most sites of fragility fracture. The contribution of increasing population rates of obesity to apparent decreases in fracture rates should be explored. © 2014 American Society for Bone and Mineral Research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Kanis, John A4 aut
7001 a Odén, Anders,d 19424 aut
7001 a McCloskey, Eugene4 aut
7001 a Chapurlat, Roland D4 aut
7001 a Christiansen, Claus4 aut
7001 a Cummings, Steve R4 aut
7001 a Diez-Perez, Adolfo4 aut
7001 a Eisman, John A4 aut
7001 a Fujiwara, Saeko4 aut
7001 a Glüer, Claus-C4 aut
7001 a Goltzman, David4 aut
7001 a Hans, Didier4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Krieg, Marc-Antoine4 aut
7001 a Kröger, Heikki4 aut
7001 a Lacroix, Andrea Z4 aut
7001 a Lau, Edith4 aut
7001 a Leslie, William D4 aut
7001 a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine,University of Gothenburg4 aut0 (Swepub:gu)xmelda
7001 a Melton, L Joseph4 aut
7001 a O'Neill, Terence W4 aut
7001 a Pasco, Julie A4 aut
7001 a Prior, Jerilynn C4 aut
7001 a Reid, David M4 aut
7001 a Rivadeneira, Fernando4 aut
7001 a van Staa, Tjerd4 aut
7001 a Yoshimura, Noriko4 aut
7001 a Zillikens, M Carola4 aut
7102 a Göteborgs universitetb Centre for Bone and Arthritis Research4 org
7730 t Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Researchd : Wileyg 29:1, s. 223-33q 29:1<223-33x 1523-4681
7730 t Journal of Bone and Mineral Researchd : Wileyg 29:1, s. 223-33q 29:1<223-33x 0884-0431
8564 u http://dx.doi.org/10.1002/jbmr.2017y FULLTEXT
8564 8u https://gup.ub.gu.se/publication/190426
8564 8u https://doi.org/10.1002/jbmr.2017
8564 8u https://research.chalmers.se/publication/190426

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