Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

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Sökning: (WFRF:(Esko Tonu)) pers:(Rudan Igor) pers:(Vitart Veronique) > Modulation of Genet...

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Fältnamn	Indikatorer	Metadata
000		07712naa a2201753 4500
001		oai:DiVA.org:uu-258896
003		SwePub
008		150721s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2588962 URI
024	7	a https://doi.org/10.1371/journal.pone.01197522 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Huffman, Jennifer E.4 aut
245	1 0	a Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
264		c 2015-03-26
264	1	b Public Library of Science (PLoS),c 2015
338		a electronic2 rdacarrier
520		a We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, P-inter= 2.6 x 10(-8)). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDAR-ADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10(-8)), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10(-8)), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10(-4)). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Albrecht, Eva4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Kapur, Karen4 aut
700	1	a Johnson, Toby4 aut
700	1	a Kutalik, Zoltn4 aut
700	1	a Pirastu, Nicola4 aut
700	1	a Pistis, Giorgio4 aut
700	1	a Lopez, Lorna M.4 aut
700	1	a Haller, Toomas4 aut
700	1	a Salo, Perttu4 aut
700	1	a Goel, Anuj4 aut
700	1	a Li, Man4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Ruggiero, Daniela4 aut
700	1	a Malerba, Giovanni4 aut
700	1	a Smith, Albert V.4 aut
700	1	a Nolte, Ilja M.4 aut
700	1	a Portas, Laura4 aut
700	1	a Phipps-Green, Amanda4 aut
700	1	a Boteva, Lora4 aut
700	1	a Navarro, Pau4 aut
700	1	a Johansson, Åsau Uppsala universitet,Medicinsk genetik och genomik,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)asjoh108
700	1	a Hicks, Andrew A.4 aut
700	1	a Polasek, Ozren4 aut
700	1	a Esko, Tonu4 aut
700	1	a Peden, John F.4 aut
700	1	a Harris, Sarah E.4 aut
700	1	a Murgia, Federico4 aut
700	1	a Wild, Sarah H.4 aut
700	1	a Tenesa, Albert4 aut
700	1	a Tin, Adrienne4 aut
700	1	a Mihailov, Evelin4 aut
700	1	a Grotevendt, Anne4 aut
700	1	a Gislason, Gauti K.4 aut
700	1	a Coresh, Josef4 aut
700	1	a D'Adamo, Pio4 aut
700	1	a Ulivi, Sheila4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Waeber, Gerard4 aut
700	1	a Campbell, Susan4 aut
700	1	a Kolcic, Ivana4 aut
700	1	a Fisher, Krista4 aut
700	1	a Viigimaa, Margus4 aut
700	1	a Metter, Jeffrey E.4 aut
700	1	a Masciullo, Corrado4 aut
700	1	a Trabetti, Elisabetta4 aut
700	1	a Bombieri, Cristina4 aut
700	1	a Sorice, Rossella4 aut
700	1	a Doering, Angela4 aut
700	1	a Reischl, Eva4 aut
700	1	a Strauch, Konstantin4 aut
700	1	a Hofman, Albert4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Waldenberger, Melanie4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Davies, Gail4 aut
700	1	a Gow, Alan J.4 aut
700	1	a Dalbeth, Nicola4 aut
700	1	a Stamp, Lisa4 aut
700	1	a Smit, Johannes H.4 aut
700	1	a Kirin, Mirna4 aut
700	1	a Nagaraja, Ramaiah4 aut
700	1	a Nauck, Matthias4 aut
700	1	a Schurmann, Claudia4 aut
700	1	a Budde, Kathrin4 aut
700	1	a Farrington, Susan M.4 aut
700	1	a Theodoratou, Evropi4 aut
700	1	a Jula, Antti4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Sala, Cinzia4 aut
700	1	a Hengstenberg, Christian4 aut
700	1	a Burnier, Michel4 aut
700	1	a Maegi, Reedik4 aut
700	1	a Klopp, Norman4 aut
700	1	a Kloiber, Stefan4 aut
700	1	a Schipf, Sabine4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Cabras, Stefano4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a Homuth, Georg4 aut
700	1	a Nutile, Teresa4 aut
700	1	a Munroe, Patricia B.4 aut
700	1	a Hastie, Nicholas4 aut
700	1	a Campbell, Harry4 aut
700	1	a Rudan, Igor4 aut
700	1	a Cabrera, Claudia4 aut
700	1	a Haley, Chris4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Merriman, Tony R.4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Pirastu, Mario4 aut
700	1	a Penninx, Brenda W.4 aut
700	1	a Snieder, Harold4 aut
700	1	a Metspalu, Andres4 aut
700	1	a Ciullo, Marina4 aut
700	1	a Pramstaller, Peter P.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Gambaro, Giovanni4 aut
700	1	a Deary, Ian J.4 aut
700	1	a Dunlop, Malcolm G.4 aut
700	1	a Wilson, James F.4 aut
700	1	a Gasparini, Paolo4 aut
700	1	a Gyllensten, Ulfu Uppsala universitet,Medicinsk genetik och genomik4 aut0 (Swepub:uu)ulfgyll
700	1	a Spector, Tim D.4 aut
700	1	a Wright, Alan F.4 aut
700	1	a Hayward, Caroline4 aut
700	1	a Watkins, Hugh4 aut
700	1	a Perola, Markus4 aut
700	1	a Bochud, Murielle4 aut
700	1	a Kao, W. H. Linda4 aut
700	1	a Caulfield, Mark4 aut
700	1	a Toniolo, Daniela4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Gieger, Christian4 aut
700	1	a Koettgen, Anna4 aut
700	1	a Vitart, Veronique4 aut
710	2	a Uppsala universitetb Medicinsk genetik och genomik4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 10:3q 10:3x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0119752y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:842630/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://doi.org/10.1371/journal.pone.0119752
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258896
856	4 8	u https://doi.org/10.1371/journal.pone.0119752

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Av författaren/redakt...: Huffman, Jennife ...; Albrecht, Eva; Teumer, Alexande ...; Mangino, Massimo; Kapur, Karen; Johnson, Toby; visa fler...; Kutalik, Zoltn; Pirastu, Nicola; Pistis, Giorgio; Lopez, Lorna M.; Haller, Toomas; Salo, Perttu; Goel, Anuj; Li, Man; Tanaka, Toshiko; Dehghan, Abbas; Ruggiero, Daniel ...; Malerba, Giovann ...; Smith, Albert V.; Nolte, Ilja M.; Portas, Laura; Phipps-Green, Am ...; Boteva, Lora; Navarro, Pau; Johansson, Åsa; Hicks, Andrew A.; Polasek, Ozren; Esko, Tonu; Peden, John F.; Harris, Sarah E.; Murgia, Federico; Wild, Sarah H.; Tenesa, Albert; Tin, Adrienne; Mihailov, Evelin; Grotevendt, Anne; Gislason, Gauti ...; Coresh, Josef; D'Adamo, Pio; Ulivi, Sheila; Vollenweider, Pe ...; Waeber, Gerard; Campbell, Susan; Kolcic, Ivana; Fisher, Krista; Viigimaa, Margus; Metter, Jeffrey ...; Masciullo, Corra ...; Trabetti, Elisab ...; Bombieri, Cristi ...; Sorice, Rossella; Doering, Angela; Reischl, Eva; Strauch, Konstan ...; Hofman, Albert; Uitterlinden, An ...; Waldenberger, Me ...; Wichmann, H-Eric ...; Davies, Gail; Gow, Alan J.; Dalbeth, Nicola; Stamp, Lisa; Smit, Johannes H ...; Kirin, Mirna; Nagaraja, Ramaia ...; Nauck, Matthias; Schurmann, Claud ...; Budde, Kathrin; Farrington, Susa ...; Theodoratou, Evr ...; Jula, Antti; Salomaa, Veikko; Sala, Cinzia; Hengstenberg, Ch ...; Burnier, Michel; Maegi, Reedik; Klopp, Norman; Kloiber, Stefan; Schipf, Sabine; Ripatti, Samuli; Cabras, Stefano; Soranzo, Nicole; Homuth, Georg; Nutile, Teresa; Munroe, Patricia ...; Hastie, Nicholas; Campbell, Harry; Rudan, Igor; Cabrera, Claudia; Haley, Chris; Franco, Oscar H.; Merriman, Tony R ...; Gudnason, Vilmun ...; Pirastu, Mario; Penninx, Brenda ...; Snieder, Harold; Metspalu, Andres; Ciullo, Marina; Pramstaller, Pet ...; van Duijn, Corne ...; Ferrucci, Luigi; Gambaro, Giovann ...; Deary, Ian J.; Dunlop, Malcolm ...; Wilson, James F.; Gasparini, Paolo; Gyllensten, Ulf; Spector, Tim D.; Wright, Alan F.; Hayward, Carolin ...; Watkins, Hugh; Perola, Markus; Bochud, Murielle; Kao, W. H. Linda; Caulfield, Mark; Toniolo, Daniela; Voelzke, Henry; Gieger, Christia ...; Koettgen, Anna; Vitart, Veroniqu ...; visa färre...

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