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  • ter Veer, EmilAcad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands (author)

Consensus statement on mandatory measurements in pancreatic cancer trials (COMM-PACT) for systemic treatment of unresectable disease

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-352928
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352928URI
  • https://doi.org/10.1016/S1470-2045(18)30098-6DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Variations in the reporting of potentially confounding variables in studies investigating systemic treatments for unresectable pancreatic cancer pose challenges in drawing accurate comparisons between findings. In this Review, we establish the first international consensus on mandatory baseline and prognostic characteristics in future trials for the treatment of unresectable pancreatic cancer. We did a systematic literature search to find phase 3 trials investigating first-line systemic treatment for locally advanced or metastatic pancreatic cancer to identify baseline characteristics and prognostic variables. We created a structured overview showing the reporting frequencies of baseline characteristics and the prognostic relevance of identified variables. We used a modified Delphi panel of two rounds involving an international panel of 23 leading medical oncologists in the field of pancreatic cancer to develop a consensus on the various variables identified. In total, 39 randomised controlled trials that had data on 15 863 patients were included, of which 32 baseline characteristics and 26 prognostic characteristics were identified. After two consensus rounds, 23 baseline characteristics and 12 prognostic characteristics were designated as mandatory for future pancreatic cancer trials. The COnsensus statement on Mandatory Measurements in unresectable PAncreatic Cancer Trials (COMM-PACT) identifies a mandatory set of baseline and prognostic characteristics to allow adequate comparison of outcomes between pancreatic cancer studies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • van Rijssen, L. BengtAcad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • Besselink, Marc G.Acad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • Mali, Rosa M. A.Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands. (author)
  • Berlin, Jordan D.Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. (author)
  • Boeck, StefanLudwig Maximilians Univ Munchen, Klinikum Grosshadern, Ctr Comprehens Canc, Dept Internal Med 3, Munich, Germany. (author)
  • Bonnetain, FranckUniv Hosp Besancon, Methodol & Qual Life Oncol Unit, Besancon, France. (author)
  • Chau, IanRoyal Marsden NHS Fdn Trust, London, England.;Royal Marsden NHS Fdn Trust, Brompton, Surrey, England. (author)
  • Conroy, ThierryInst Cancerol Lorraine, Dept Med Oncol, Vandoeuvre Less Nancy, France.;Lorraine Univ, Vandoeuvre Less Nancy, France. (author)
  • Van Cutsem, EricUniv Hosp Gasthuisberg Leuven, Dept Gastroenterol & Digest Oncol, Leuven, Belgium.;Katholieke Univ Leuven, Leuven, Belgium. (author)
  • Deplanque, GaelHop Riviera Chablais, Dept Oncol, Vevey, Switzerland. (author)
  • Friess, HelmutTech Univ Munich, Klinikum Rechts Isar, Dept Surg, Munich, Germany. (author)
  • Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim (author)
  • Goldstein, DavidUniv New South Wales, Prince Wales Clin Sch, Prince Wales Hosp, Nelune Canc Ctr, Randwick, NSW, Australia. (author)
  • Herrmann, RichardUniv Hosp Basel, Dept Med Oncol, Basel, Switzerland. (author)
  • Labianca, RobertoASST Papa Giovanni XXIII, Ctr Canc, Bergamo, Italy. (author)
  • Van Laethem, Jean-LucUniv Libre Bruxelles, Erasme Univ Hosp, Gastrointestinal Canc Unit, Dept Gastroenterol, Brussels, Belgium. (author)
  • Macarulla, TeresaVall dHebron Inst Oncol VHIO, Vall dHebron Univ Hosp, Barcelona, Spain. (author)
  • van der Meer, Jonathan H. M.Acad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • Neoptolemos, John P.Univ Liverpool, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England. (author)
  • Okusaka, TakujiNatl Canc Ctr, Dept Hepatobiliary & Pancreat Oncol, Tokyo, Japan. (author)
  • O'Reilly, Eileen M.Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Dept Med, Gastrointestinal Oncol Serv,Div Solid Tumor Oncol, New York, NY USA. (author)
  • Pelzer, UweCharite Univ Med Berlin, Dept Hematol Oncol & Tumor Immunol, Berlin, Germany.;Humboldt Univ, Freie Univ Berlin, Berlin, Germany.;Berlin Inst Hlth, Berlin, Germany. (author)
  • Philip, Philip A.Wayne State Univ, Dept Oncol, Karmanos Canc Ctr, Detroit, MI USA. (author)
  • van der Poel, Marcel J.Acad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • Reni, MicheleIRCCS San Raffaele Sci Inst, Dept Med Oncol, Milan, Italy. (author)
  • Scheithauer, WernerMed Univ Vienna, Dept Internal Med 1, Vienna, Austria. (author)
  • Siveke, Jens T.Univ Hosp Essen, West German Canc Canc, Div Solid Tumor, Translat Oncol, Essen, Germany.;German Canc Consortium DKTK, Partner Site Essen, Heidelberg, Germany.;DKFZ, German Canc Res Ctr, Heidelberg, Germany. (author)
  • Verslype, ChrisUniv Hosp Leuven, Dept Digest Oncol, Leuven, Belgium. (author)
  • Busch, Olivier R.Acad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (author)
  • Wilmink, Johanna W.Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands. (author)
  • van Oijen, Martijn G. H.Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands. (author)
  • van Laarhoven, Hanneke W. M.Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, Netherlands. (author)
  • Acad Med Ctr, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam, NetherlandsAcad Med Ctr, Canc Ctr Amsterdam, Dept Surg, Amsterdam, Netherlands. (creator_code:org_t)

Related titles

  • In:The Lancet Oncology19:3, s. E151-E1601470-20451474-5488

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