Sökning: (WFRF:(Hamsten Anders)) pers:(Palmer Colin N. A.)
> (2015-2019) >
Sex-Specific Effect...
Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
-
- Persson, Jonas (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.
-
- Strawbridge, Rona J. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
-
- McLeod, Olga (författare)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden
-
visa fler...
-
- Gertow, Karl (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
-
- Silveira, Angela (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
-
- Baldassarre, Damiano (författare)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
-
- Van Zuydam, Natalie (författare)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
-
- Shah, Sonia (författare)
- UCL, Genet Inst, London, England.;Univ Queensland, Diamantina Inst, Brisbane, Qld 4072, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.,UCL, England; University of Queensland, Australia; University of Queensland, Australia
-
- Fava, Cristiano (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden; University of Verona, Italy,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.;Univ Verona, Hosp Policlin GB Rossi, Dept Med, Div Internal Med C, I-37100 Verona, Italy.
-
- Gustafsson, Stefan (författare)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden
-
- Veglia, Fabrizio (författare)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
-
- Sennblad, Bengt (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;Karolinska Inst, Sci Life Lab, Stockholm, Sweden.
-
- Larsson, Malin (författare)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten,Linkoping Univ, IFM Bioinformat, Linkoping, Sweden.
-
- Sabater-Lleal, Maria (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.
-
- Leander, Karin (författare)
- Karolinska Institutet
-
- Gigante, Bruna (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.;Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
-
- Tabak, Adam (författare)
- Semmelweis Univ, Fac Med, Dept Med 1, H-1085 Budapest, Hungary.,Semmelweis University, Hungary
-
- Kivimaki, Mika (författare)
- UCL, Dept Epidemiol & Publ Hlth, London, England.
-
- Kauhanen, Jussi (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.,University of Eastern Finland, Finland
-
- Rauramaa, Rainer (författare)
- Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.,Kuopio Research Institute Exercise Med, Finland; Kuopio University Hospital, Finland
-
- Smit, Andries J. (författare)
- Univ Groningen, Univ Med Ctr Groningen, Dept Med, NL-9700 AB Groningen, Netherlands.,University of Groningen, Netherlands
-
- Mannarino, Elmo (författare)
- Univ Perugia, Dept Clin & Expt Med, Internal Med Angiol & Arteriosclerosis Dis, I-06100 Perugia, Italy.,University of Perugia, Italy
-
- Giral, Philippe (författare)
- Grp Hosp Pitie Salpetriere, AP HP, Serv Endocrinol Metab, Unites Prevent Cardiovasc, F-75634 Paris, France.,Grp Hospital Pitie Salpetriere, France
-
- Humphries, Steve E. (författare)
- UCL, Ctr Cardiovasc Genet, London, England.
-
- Tremoli, Elena (författare)
- Univ Milan, Dipartimento Sci Farmacol & Biomol, Milan, Italy.,University of Milan, Italy
-
- de Faire, Ulf (författare)
- Karolinska Institutet,Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.
-
- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden
-
- Ingelsson, Erik (författare)
- Uppsala universitet,Molekylär epidemiologi,Uppsala University, Sweden
-
- Hedblad, Bo (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.
-
- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital,Lund University, Sweden,Lund Univ, Skane Univ Hosp, Dept Clin Sci, Clin Res Ctr, Malmo, Sweden.
-
- Kumari, Meena (författare)
- UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.
-
- Hingorani, Aroon (författare)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.;UCL, Genet Epidemiol Grp, Dept Epidemiol & Publ Hlth, London, England.,Karolinska Institute, Sweden; UCL, England
-
- Morris, Andrew D. (författare)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
-
- Palmer, Colin N. A. (författare)
- Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Dundee DD1 4HN, Scotland.,University of Dundee, Scotland
-
- Lundman, Pia (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden.
-
- Ohrvik, John (författare)
- Karolinska Inst, Dept Med Solna, Atherosclerosis Res Unit, Stockholm, Sweden.,Karolinska Institute, Sweden
-
- Söderberg, Stefan (författare)
- Umeå universitet,Kardiologi,Umea Univ, Dept Publ Hlth & Clin Med, Div Med, S-90187 Umea, Sweden.
-
Hamsten, Anders (författare)
-
visa färre...
-
Karolinska Institutet Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Karolinska Inst, S-18288 Danderyd, Sweden (creator_code:org_t)
- WILEY-BLACKWELL, 2015
- 2015
- Engelska.
-
Ingår i: Journal of the American Heart Association. - : WILEY-BLACKWELL. - 2047-9980. ; 4:8
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://portal.resea... (primary) (free)
-
http://www.ncbi.nlm.... (free)
-
http://dx.doi.org/10... (free)
-
https://liu.diva-por... (primary) (Raw object)
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- adiponectin
- atherosclerosis
- carotid intima-media thickness
- genetics
- Mendelian randomization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Persson, Jonas
-
Strawbridge, Ron ...
-
McLeod, Olga
-
Gertow, Karl
-
Silveira, Angela
-
Baldassarre, Dam ...
-
visa fler...
-
Van Zuydam, Nata ...
-
Shah, Sonia
-
Fava, Cristiano
-
Gustafsson, Stef ...
-
Veglia, Fabrizio
-
Sennblad, Bengt
-
Larsson, Malin
-
Sabater-Lleal, M ...
-
Leander, Karin
-
Gigante, Bruna
-
Tabak, Adam
-
Kivimaki, Mika
-
Kauhanen, Jussi
-
Rauramaa, Rainer
-
Smit, Andries J.
-
Mannarino, Elmo
-
Giral, Philippe
-
Humphries, Steve ...
-
Tremoli, Elena
-
de Faire, Ulf
-
Lind, Lars
-
Ingelsson, Erik
-
Hedblad, Bo
-
Melander, Olle
-
Kumari, Meena
-
Hingorani, Aroon
-
Morris, Andrew D ...
-
Palmer, Colin N. ...
-
Lundman, Pia
-
Ohrvik, John
-
Söderberg, Stefa ...
-
Hamsten, Anders
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Uppsala universitet
-
Lunds universitet
-
Linköpings universitet
-
Karolinska Institutet
-
Umeå universitet