Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe

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Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe

Gyawali, S. (författare): Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.

Lopez-Cervantes, J. P. (författare): Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.

Johannessen, A. (författare): Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.

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Gislason, T. (författare): Faculty of Medical, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland,Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp, Dept Sleep, Reykjavik, Iceland.

Holm, Mathias, 1969 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Sahlgrenska Acad,Occupat & Environm Med, Gothenburg, Sweden.

Janson, Christer (författare): Uppsala universitet,Lung- allergi- och sömnforskning

Jögi, Rain (författare): Uppsala universitet,Lung- allergi- och sömnforskning,Tartu Univ Hosp, Lung Clin, Tartu, Estonia.

Modig, Lars (författare): Umeå universitet,Avdelningen för hållbar hälsa,Umeå Univ, Dept Publ Hlth & Clin Med, Sustainable Hlth, Umeå, Sweden.

Schlunssen, V. (författare): Department of Public Health, Research Unit for Environment, Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark,Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth, Res Unit Environm Occupat & Hlth, Aarhus, Denmark.

Mustafa, T. (författare): Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Dept Thorac Med, Bergen, Norway.

Svanes, C. (författare): Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Dept Occupat Med, Bergen, Norway.

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Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway Univ Bergen, Ctr Int Hlth, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Haukeland Hosp, Dept Occupat Med, Bergen, Norway. (creator_code:org_t)

Frontiers Media S.A. 2023
2023
Engelska.
Ingår i: Frontiers in Allergy. - : Frontiers Media S.A.. - 2673-6101. ; 4

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.3...; https://urn.kb.se/re...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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BackgroundGiven the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.ObjectiveThis study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.MethodsWe included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.ResultsOf 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05-1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29-2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76-1.32) in offspring was observed.ConclusionResults from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

asthma
tuberculosis
epigenetic
offspring asthma
generational study
risk
Allergy
asthma

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Av författaren/redakt...: Gyawali, S.; Lopez-Cervantes, ...; Johannessen, A.; Gislason, T.; Holm, Mathias, 1 ...; Janson, Christer; visa fler...; Jögi, Rain; Modig, Lars; Schlunssen, V.; Mustafa, T.; Svanes, C.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

Artiklar i publikationen: Frontiers in All ...

Av lärosätet: Göteborgs universitet; Umeå universitet; Uppsala universitet

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