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On the etiology of ...
On the etiology of incident brain lacunes: longitudinal observations from the LADIS study.
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Gouw, Alida A (författare)
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van der Flier, Wiesje M (författare)
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Pantoni, Leonardo (författare)
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Inzitari, Domenico (författare)
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Erkinjuntti, Timo (författare)
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- Wahlund, Lars O (författare)
- Karolinska Institutet
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Waldemar, Gunhild (författare)
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Schmidt, Reinhold (författare)
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Fazekas, Franz (författare)
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Scheltens, Philip (författare)
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Barkhof, Frederik (författare)
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- Wallin, Anders, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Stroke; a journal of cerebral circulation. - 1524-4628. ; 39:11, s. 3083-5
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Basal Ganglia
- pathology
- Brain Infarction
- etiology
- pathology
- Humans
- Leukoaraiosis
- pathology
- Longitudinal Studies
- Magnetic Resonance Imaging
- Nerve Fibers
- Myelinated
- pathology
- Risk Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Gouw, Alida A
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van der Flier, W ...
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Pantoni, Leonard ...
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Inzitari, Domeni ...
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Erkinjuntti, Tim ...
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Wahlund, Lars O
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visa fler...
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Waldemar, Gunhil ...
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Schmidt, Reinhol ...
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Fazekas, Franz
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Scheltens, Phili ...
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Barkhof, Frederi ...
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Wallin, Anders, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Stroke; a journa ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet