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The Ile646Val (2073...
The Ile646Val (2073A > G) Polymorphism in the Kinase-Binding Domain of A-Kinase Anchoring Protein 10 and the Risk of Colorectal Cancer
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- Wang, Mo-Jin (författare)
- Sichuan University
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- Zhou, Zong-Guang (författare)
- Sichuan University
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- Wang, Ling (författare)
- Sichuan University
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- Yu, Yong-Yang (författare)
- Sichuan University
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- Zhang, Peng (författare)
- Sichuan University
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- Zhang, Yi (författare)
- Sichuan University
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- Cui, Chang-Fu (författare)
- Sichuan University
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- Yang, Lie (författare)
- Sichuan University
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- Li, Yuan (författare)
- Sichuan University
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- Zhou, Bin (författare)
- Sichuan University
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- Sun, Xiao-Feng (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- 2009-02-11
- 2009
- Engelska.
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Ingår i: ONCOLOGY. - : S. Karger AG. - 0030-2414 .- 1423-0232. ; 76:3, s. 199-204
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC. Methods: Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls. Results: Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08 - 3.05, p = 0.01) among young subjects (age ! 57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08 - 2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors. Conclusions: Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.
Nyckelord
- A-kinase anchoring protein 10
- Polymorphism
- 2073A >
- G
- Colorectal cancer
- MEDICINE
- MEDICIN
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Wang, Mo-Jin
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Zhou, Zong-Guang
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Wang, Ling
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Yu, Yong-Yang
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Zhang, Peng
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Zhang, Yi
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Cui, Chang-Fu
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Yang, Lie
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Li, Yuan
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Zhou, Bin
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Sun, Xiao-Feng
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ONCOLOGY
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Linköpings universitet