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FältnamnIndikatorerMetadata
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001oai:DiVA.org:umu-180686
003SwePub
008210222s2021 | |||||||||||000 ||eng|
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009oai:prod.swepub.kib.ki.se:145710860
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1806862 URI
024a https://doi.org/10.1038/s41467-020-19366-92 DOI
024a https://lup.lub.lu.se/record/552b88a0-b694-4dd6-afd2-b25ccd8b584f2 URI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4357572 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1457108602 URI
040 a (SwePub)umud (SwePub)lud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Lagou, Vasilikiu University of Oxford,Catholic University of Leuven,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Katholieke Univ Leuven, Lab Adapt Immun, Dept Microbiol & Immunol, Leuven, Belgium.;VIB KU Leuven Ctr Brain & Dis Res, Leuven, Belgium.4 aut
2451 0a Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
264 c 2021-01-05
264 1b Nature Publishing Group,c 2021
338 a electronic2 rdacarrier
500 a Errata: Lagou, V., Mägi, R., Hottenga, J.J. et al. Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021;12:995. DOI:10.1038/s41467-021-21276-3
520 a Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses in individuals of European descent without diabetes. Here we report sex dimorphism in allelic effects on fasting insulin at IRS1 and ZNF12 loci, the latter showing higher RNA expression in whole blood in women compared to men. We also observe sex-homogeneous effects on fasting glucose at seven novel loci. Fasting insulin in women shows stronger genetic correlations than in men with waist-to-hip ratio and anorexia nervosa. Furthermore, waist-to-hip ratio is causally related to insulin resistance in women, but not in men. These results position dissection of metabolic and glycemic health sex dimorphism as a steppingstone for understanding differences in genetic effects between women and men in related phenotypes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700a Maegi, Reediku Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Hottenga, Jouke- Janu Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam, Netherlands.4 aut
700a Grallert, Haraldu Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;German Ctr Diabet Res DZD, Munich, Germany.4 aut
700a Perry, John R. B.u Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.,Kuopio Res Inst Exercise Med, Kuopio, Finland.;Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, Kuopio, Finland.,CESP Ctr Res Epidemiol & Publ Hlth, Inserm, U1018, Villejuif, France.;Univ Paris Sud, Univ Paris Saclay, UVSQ, UMRS 1018,UMRS 1018, Villejuif, France.4 aut
700a Bouatia-Naji, Nabilau Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Paris Cardiovasc Res Ctr PARCC, INSERM U970, F-75006 Paris, France.4 aut
700a Marullo, Letiziau Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.4 aut
700a Rybin, Denisu Boston Univ, Data Coordinating Ctr, Boston, MA 02215 USA.4 aut
700a Jansen, Ricku Karolinska Institutet4 aut
700a Lind, Larsu Karolinska Institutet,Uppsala universitet,Klinisk epidemiologi,Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.,Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut0 (Swepub:uu)larslind
700a Dimas, Antigone S.u Biomed Sci Res Ctr Al, Inst Bioinnovat, Vari, Greece.,CNR, Ist Ric Genet & Biomed, Monserrato, Italy.;Univ Groningen, Univ Med Ctr, Dept Genet, Groningen, Netherlands.4 aut
700a Ulrich, Annau Imperial Coll, Dept Med, London, England.,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Zudina, Liudmilau Imperial Coll, Dept Med, London, England.4 aut
700a Gadin, Jesper R.u Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiovasc Med Unit,Ctr Mol Med, Solna, Sweden.4 aut
700a Jiang, Longdau Imperial Coll, Dept Med, London, England.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.4 aut
700a Faggian, Alessiau Imperial Coll, Dept Med, London, England.4 aut
700a Bonnefond, Amelieu Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Imperial Coll, Dept Med, London, England.4 aut
700a Fadista, Joaou Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.;Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.4 aut
700a Stathopoulou, Maria G.u Univ Lorraine, IGE PCV, F-54000 Nancy, France.4 aut
700a Isaacs, Aaronu Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Maastricht Univ, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands.;Maastricht Univ, Maastricht Ctr Syst Biol MaCSBio, Maastricht, Netherlands.;Maastricht Univ, Dept Physiol, Maastricht, Netherlands.4 aut
700a Willems, Sara M.u Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.4 aut
700a Navarro, Pauu Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Tanaka, Toshikou NIA, Translat Gerontol Branch, Longitudinal Study Sect, Baltimore, MD 21224 USA.,Univ Geneva, Med Sch, Dept Genet Med & Dev, Geneva, Switzerland.4 aut
700a Jackson, Anne U.4 aut
700a Montasser, May E.u Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.4 aut
700a O'Connell, Jeff R.u Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.4 aut
700a Bielak, Lawrence F.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut
700a Webster, Rebecca J.u Univ Western Australia, Med Res Ctr, Harry Perkins Inst Med Res, Lab Canc Med, Nedlands, WA, Australia.4 aut
700a Saxena, Richau Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.;MGH, Dept Anesthesia Crit Care & Pain Med, Boston, MA USA.4 aut
700a Stafford, Jeanette M.u Wake Forest Univ, Div Publ Hlth Sci, Dept Biostat & Data Sci, Winston Salem, NC 27101 USA.4 aut
700a Pourcain, Beate Stu Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Bristol, Avon, England.4 aut
700a Timpson, Nicholas J.u Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Bristol, Avon, England.4 aut
700a Salo, Perttuu Finnish Inst Hlth & Welf, Dept Chron Dis Prevent, Publ Hlth Genom Unit, Helsinki, Finland.4 aut
700a Shin, So-Younu Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.4 aut
700a Amin, Najafu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.,Univ Dundee, Pat McPherson Ctr Pharmacogenet & Pharmacogenom, Div Mol & Clin Med, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland.4 aut
700a Smith, Albert V.u Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.;Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.,Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Li, Guou Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Med, Seattle, WA USA.4 aut
700a Verweij, Nieku Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.4 aut
700a Goel, Anuju Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Cardiovasc Med, Oxford, England.4 aut
700a Ford, Ianu Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland.4 aut
700a Johnson, Paul C. D.u Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland.;Queen Mary Univ London, Barts & London Sch Med & Dent, Glasgow, Lanark, Scotland.4 aut
700a Johnson, Tobyu Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Unit, London, England.4 aut
700a Kapur, Karenu Karolinska Institutet4 aut
700a Thorleifsson, Gudmaru deCODE Genet, Reykjavik, Iceland.4 aut
700a Strawbridge, Rona J.u Dept Med, Cardiovasc Med Unit, Solna, Sweden.;Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp Solna, Ctr Mol Med, Stockholm, Sweden.;Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.4 aut
700a Rasmussen-Torvik, Laura J.u Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.4 aut
700a Esko, Tonuu Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Mihailov, Evelinu Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Fall, Tove,d 1979-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:uu)tovfa878
700a Fraser, Ross M.u Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.;Synpr Ltd, Roslin Innovat Ctr, Easter Bush Campus, Edinburgh EH25 9RG, Midlothian, Scotland.4 aut
700a Mahajan, Anubhau Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Genentech Inc, 340 Point San Bruno Blvd, San Francisco, CA 94080 USA.4 aut
700a Kanoni, Stavroulau Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Wellcome Trust Sanger Inst, Hinxton, England.4 aut
700a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517
700a Kleber, Marcus E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut
700a Silbernagel, Guentheru Med Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria.4 aut
700a Meyer, Juliau Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.4 aut
700a Mueller-Nurasyid, Martinau Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol & Chair Genet Epidemiol, Munich, Germany.;Ludwig Maximilians Univ Munchen, Univ Hosp Grosshadern, Dept Med 1, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, IMBEI, D-55101 Mainz, Germany.4 aut
700a Ganna, Andreau Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA USA.;Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA.4 aut
700a Sarin, Antti-Pekkau Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Finnish Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.4 aut
700a Yengo, Loicu Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.4 aut
700a Shungin, Dmitryu Umeå universitet,Institutionen för odontologi,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.;Skane Univ Hosp Malmö, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmö, Sweden.;Umeå Univ, Dept Odontol, Umeå, Sweden.4 aut0 (Swepub:umu)dmsh0003
700a Luan, Jian'anu Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
700a Horikoshi, Momokou Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;RIKEN, Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa, Japan.4 aut
700a An, Pingu Washington Univ, Div Stat Genom, Sch Med, Washington, DC USA.4 aut
700a Sanna, Serenau Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.,Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Med, Seattle, WA USA.;Univ Washington, Dept Epidemiol, Seattle, WA USA.4 aut
700a Boettcher, Yvonneu Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.4 aut
700a Rayner, N. Williamu Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Wellcome Trust Sanger Inst, Hinxton, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Nolte, Ilja M.u Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Zemunik, Tatijanau Univ Split, Fac Med, Split, Croatia.4 aut
700a Iperen, Erik vanu Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands.4 aut
700a Kovacs, Peteru Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.4 aut
700a Hastie, Nicholas D.u Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Wild, Sarah H.u Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a McLachlan, Stelau Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a Campbell, Susanu Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Polasek, Ozrenu Univ Split, Fac Med, Split, Croatia.4 aut
700a Carlson, Olgau NIA, Lab Clin Invest, Baltimore, MD 21224 USA.4 aut
700a Egan, Josephineu NIA, Lab Clin Invest, Baltimore, MD 21224 USA.4 aut
700a Kiess, Wielandu Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Univ Leipzig, Dept Womens & Child Hlth, Pediat Res Ctr, Leipzig, Germany.4 aut
700a Willemsen, Gonnekeu Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.4 aut
700a Kuusisto, Johannau Univ Eastern Finland, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.4 aut
700a Laakso, Markkuu Univ Eastern Finland, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Dept Med, Kuopio, Finland.;Kuopio Univ Hosp, Kuopio, Finland.4 aut
700a Dimitriou, Mariau Harokopio Univ, Dept Dietet Nutr, Athens, Greece.4 aut
700a Hicks, Andrew A.u Univ Lubeck Lubeck Germany, Ctr Biomed, European Acad Bozen Bolzano EURAC, Affiliated Inst, Bolzano, Italy.4 aut
700a Rauramaa, Raineru Univ Groningen, Dept Endocrinol, Univ Med Ctr Groningen, Groningen, Netherlands.,Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.,Tech Univ Dresden, Dept Med, Div Prevent & Care Diabet, Fac Med Carl Gustav Carus, Dresden, Germany.,Cardiol Grp, Frankfurt, Germany.,Univ Maryland, Div Endocrinol Diabet & Nutr, Dept Med, Sch Med, Baltimore, MD 21201 USA.;Regeneron Pharmaceut, Regeneron Genet Ctr, Tarrytown, NY USA.4 aut
700a Bandinelli, Stefaniau Azienda Sanitaria Firenze ASF, Geriatr Unit, Florence, Italy.4 aut
700a Thorand, Barbarau German Ctr Diabet Res DZD, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.4 aut
700a Liu, Yongmeiu Wake Forest Univ, Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27101 USA.4 aut
700a Miljkovic, Ivau Univ Pittsburgh, Ctr Aging & Populat Hlth, Dept Epidemiol, Pittsburgh, PA USA.4 aut
700a Lind, Lars4 aut
700a Doney, Alexu Univ Dundee, Pat McPherson Ctr Pharmacogenet & Pharmacogenom, Div Mol & Clin Med, Ninewells Hosp, Dundee, Scotland.;Univ Dundee, Sch Med, Dundee, Scotland.4 aut
700a Perola, Markusu Finnish Inst Hlth & Welf, Dept Chron Dis Prevent, Publ Hlth Genom Unit, Helsinki, Finland.;Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Hingorani, Aroonu UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut
700a Kivimaki, Mikau UCL, Dept Epidemiol & Publ Hlth, London, England.4 aut
700a Kumari, Meenau UCL, Dept Epidemiol & Publ Hlth, London, England.;Univ Essex, Wivenhoe Pk, Colchester, Essex, England.4 aut
700a Bennett, Amanda J.u Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Groves, Christopher J.u Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.4 aut
700a Herder, Christianu German Ctr Diabet Res DZD, Munich, Germany.;Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.;Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.4 aut
700a Koistinen, Heikki A.u Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.;Univ Helsinki, Dept Med, POB 340Haartmaninkatu 4, FI-00029 Helsinki, Finland.;Univ Helsinki, Cent Hosp, POB 340Haartmaninkatu 4, FI-00029 Helsinki, Finland.;Biomedicum 2U, Minerva Fdn Inst Med Res, Tukholmankatu 8, FI-00290 Helsinki, Finland.4 aut
700a Kinnunen, Leenau Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.4 aut
700a Faire, Ulf deu Karolinska Inst, Div Cardiovasc Epidemiol, Inst Environm Med, Stockholm, Sweden.4 aut
700a Bakker, Stephan J. L.u Finnish Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland.4 aut
700a Uusitupa, Mattiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.4 aut
700a Palmer, Colin N. A.4 aut
700a Jukema, J. Wouteru Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.;Netherlands Heart Inst, Utrecht, Netherlands.4 aut
700a Sattar, Naveedu Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.4 aut
700a Pouta, Anneliu Finnish Inst Hlth & Welf, Dept Govt Serv, Helsinki, Finland.;Oulu Univ Hosp, PEDEGO Res Unit, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.4 aut
700a Snieder, Haroldu Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.4 aut
700a Boerwinkle, Ericu Univ Texas Hlth Sci Ctr Houston, IMM Ctr Human Genet, Houston, TX 77030 USA.;Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol, Houston, TX 77030 USA.4 aut
700a Pankow, James S.4 aut
700a Magnusson, Patrik K.4 aut
700a Krus, Ulrikau Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.4 aut0 (Swepub:lu)medk-ufr
700a Scapoli, Chiarau Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.4 aut
700a de Geus, Eco J. C. N.u Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Med Ctr, Amsterdam, Netherlands.4 aut
700a Blueher, Matthiasu Univ Leipzig, Dept Med, Leipzig, Germany.;USC, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.4 aut
700a Wolffenbuttel, Bruce H. R.4 aut
700a Province, Michael A.u Washington Univ, Div Stat Genom, Sch Med, Washington, DC USA.4 aut
700a Abecasis, Goncalo R.4 aut
700a Meigs, James B.u Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Gen Med Div, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 aut
700a Hovingh, G. Keesu Amsterdam UMC, Dept Vasc Med, Amsterdam, Netherlands.;Novo Nordisk AS, Copenhagen, Denmark.4 aut
700a Lindstroem, Jaana4 aut
700a Wilson, James F.u Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a Wright, Alan F.u Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Dedoussis, George V.u Harokopio Univ, Dept Dietet Nutr, Athens, Greece.4 aut
700a Bornstein, Stefan R.4 aut
700a Schwarz, Peter E. H.u Karolinska Institutet4 aut
700a Toenjes, Ankeu Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.4 aut
700a Winkelmann, Bernhard R.4 aut
700a Boehm, Bernhard O.u Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore.4 aut
700a Maerz, Winfriedu Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany.4 aut
700a Metspalu, Andresu Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia.4 aut
700a Price, Jackie F.u Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a Deloukas, Panosu Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Wellcome Trust Sanger Inst, Hinxton, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah, Saudi Arabia.4 aut
700a Koerner, Antjeu Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.;Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA.4 aut
700a Lakka, Timo A.u Kuopio Res Inst Exercise Med, Kuopio, Finland.;Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.4 aut
700a Keinanen-Kiukaanniemi, Sirkka M.u Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu, Finland.;Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.4 aut
700a Saaristo, Timo E.u Finnish Diabet Assoc, Tampere, Finland.;Pirkanmaa Hosp Dist, Tampere, Finland.4 aut
700a Bergman, Richard N.u Cedars Sinai Med Ctr, Diabet & Obes Res Inst, Los Angeles, CA USA.4 aut
700a Tuomilehto, Jaakkou Finnish Diabet Assoc, Helsinki, Finland.;Inst Biomed Physiol, Helsinki, Finland.;Danube Univ Krems, Ctr Vasc Prevent, Krems, Austria.;King Abdulaziz Univ, Diabet Res Grp, Jeddah, Saudi Arabia.4 aut
700a Wareham, Nicholas J.u Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
700a Langenberg, Claudiau Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
700a Maennistoe, Satuu Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, POB 30, FI-00271 Helsinki, Finland.4 aut
700a Franks, Paul W.u Umeå universitet,Avdelningen för medicin,Näringsforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,Skane Univ Hosp Malmö, Dept Clin Sci, Genet & Mol Epidemiol Unit, Malmö, Sweden.;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Umeå Univ, Units Med & Nutr Res, Dept Publ Hlth & Clin Med, Umeå, Sweden.4 aut0 (Swepub:umu)pafr0003
700a Hayward, Carolineu Univ Edinburgh, MRC Human Genet Unit, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.4 aut
700a Vitart, Veronique4 aut
700a Kaprio, Jaakkou Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Inst Biomed Physiol, Helsinki, Finland.4 aut
700a Visvikis-Siest, Sophieu Univ Lorraine, IGE PCV, F-54000 Nancy, France.4 aut
700a Balkau, Beverleyu NIA, Geriatr Epidemiol Sect, Lab Epidemiol, Bethesda, MD USA.,Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, NIHR Barts Cardiovasc Biomed Res Unit, London, England.4 aut
700a Altshuler, Davidu Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.4 aut
700a Rudan, Igoru Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a Stumvoll, Michaelu Univ Leipzig, Dept Med, Leipzig, Germany.;Univ Leipzig, IFB Adiposity Dis, Leipzig, Germany.4 aut
700a Campbell, Harryu Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland.4 aut
700a van Duijn, Cornelia M.u Erasmus MC, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands.;Ctr Med Syst Biol, Leiden, Netherlands.4 aut
700a Gieger, Christianu Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.4 aut
700a Illig, Thomasu Helmholtz Zentrum Munchen, Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Inst Epidemiol, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.;Hannover Med Sch, Inst Human Genet, Hannover, Germany.4 aut
700a Ferrucci, Luigiu Natl Inst Aging, Clin Res Branch, Baltimore, MD USA.4 aut
700a Pedersen, Nancy L.4 aut
700a Pramstaller, Peter P.u Univ Lubeck Lubeck Germany, Ctr Biomed, European Acad Bozen Bolzano EURAC, Affiliated Inst, Bolzano, Italy.;Gen Cent Hosp, Dept Neurol, Bolzano, Italy.;Univ Lubeck, Dept Neurol, Lubeck, Germany.,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Ctr Genet & Genom Versus Arthrit, Ctr Musculoskeletal Res, Manchester, Lancs, England.4 aut
700a Boehnke, Michaelu Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.4 aut
700a Frayling, Timothy M.u Univ Exeter, Genet Complex Traits, Peninsula Med Sch, Exeter, Devon, England.4 aut
700a Shuldiner, Alan R.4 aut
700a Peyser, Patricia A.u Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.4 aut
700a Kardia, Sharon L. R.4 aut
700a Palmer, Lyle J.u Univ Adelaide, Sch Publ Hlth, Adelaide, SA, Australia.4 aut
700a Penninx, Brenda W.u Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.4 aut
700a Meneton, Pierreu Ctr Rech Cordeliers, INSERM, U872, F-75006 Paris, France.4 aut
700a Harris, Tamara B.4 aut
700a Navis, Gerjanu Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.4 aut
700a Harst, Pim van deru Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.4 aut
700a Smith, George Daveyu Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, Avon, England.4 aut
700a Forouhi, Nita G.u Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge, England.4 aut
700a Loos, Ruth J. F.4 aut
700a Salomaa, Veikkou Finnish Inst Hlth & Welf, Helsinki, Finland.4 aut
700a Soranzo, Nicoleu Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.4 aut
700a Boomsma, Dorret I.u Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands.4 aut
700a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.4 aut0 (Swepub:lu)endo-lgr
700a Tuomi, Tiinamaijau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Univ Helsinki, FIMM, Inst Mol Med Finland, Helsinki, Finland.;Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.;Univ Helsinki, Abdominal Ctr, Endocrinol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Res Program Clin & Mol Metab, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.4 aut0 (Swepub:lu)ti8736tu
700a Hofman, Albertu Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Netherlands Consortium Hlth Ageing, The Hague, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.4 aut
700a Munroe, Patricia B.4 aut
700a Gudnason, Vilmunduru Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
700a Siscovick, David S.4 aut
700a Watkins, Hughu Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Cardiovasc Med, Oxford, England.4 aut
700a Lecoeur, Cecileu Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.4 aut
700a Vollenweider, Peteru Univ Lausanne Hosp, Dept Med, Lausanne, Switzerland.4 aut
700a Franco-Cereceda, Andersu Karolinska Institutet4 aut
700a Eriksson, Peru Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiovasc Med Unit,Ctr Mol Med, Solna, Sweden.4 aut
700a Jarvelin, Marjo-Riittau Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England.;Imperial Coll London, HPA MRC Ctr, Sch Publ Hlth, London, England.;Univ Oulu, Inst Hlth Sci, Oulu, Finland.4 aut
700a Stefansson, Kariu deCODE Genet, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.4 aut
700a Hamsten, Andersu Karolinska Institutet4 aut
700a Nicholson, Georgeu Univ Oxford, Dept Stat, Oxford, England.4 aut
700a Karpe, Fredriku Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Oxford Natl Inst Hlth, Res Biomed Res Ctr, Oxford, England.4 aut
700a Dermitzakis, Emmanouil T.4 aut
700a Lindgren, Cecilia M.u Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Broad Inst Harvard & Massachusetts Inst Technol M, Cambridge, MA USA.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England.4 aut
700a McCarthy, Mark I.u Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Churchill Hosp, Oxford Natl Inst Hlth, Res Biomed Res Ctr, Oxford, England.;Genentech Inc, 340 Point San Bruno Blvd, San Francisco, CA 94080 USA.4 aut
700a Froguel, Philippeu Univ Lille Nord France, Lille, France.;Inst Pasteur, CNRS UMR8199, Lille, France.;Imperial Coll, Dept Med, London, England.4 aut
700a Kaakinen, Marika A.u Imperial Coll, Dept Med, London, England.;Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford, Surrey, England.4 aut
700a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Diabet & Endocrinol Res Unit, Malmö Univ Hosp, Lund, Sweden.;Univ Bergen, Dept Clin Sci, Bergen, Norway.4 aut0 (Swepub:lu)endo-vly
700a Watanabe, Richard M.u USC, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.;USC, Keck Sch Med, Dept Physiol & Neurosci, Los Angeles, CA USA.;USC Diabet & Obes Res Inst, Los Angeles, CA USA.4 aut
700a Ingelsson, Erik,d 1975-u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.4 aut0 (Swepub:uu)ering425
700a Florez, Jose C.u Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Diabet Res Ctr, Diabet Unit, Boston, MA 02114 USA.4 aut
700a Dupuis, Joseeu Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA.4 aut
700a Barroso, Inesu Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Hinxton, England.;Univ Cambridge, Metab Res Labs, Cambridge, England.;Univ Cambridge, NIHR Cambridge Biomed Res Ctr, Cambridge, England.;Univ Exeter, Exeter Ctr ExcEllence Diabet ExCEED, Sch Med, Exeter, Devon, England.4 aut
700a Morris, Andrew P.4 aut
700a Prokopenko, Ingau University of Surrey,Wellcome Trust Centre for Human Genetics,Imperial College London,Institute of Biochemistry and Genetics, Ufa Scientific Center RAS,University of Oxford,Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Imperial Coll, Dept Med, London, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.;Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford, Surrey, England.;Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa, Russia.;Univ Exeter, Exeter Ctr ExcEllence Diabet ExCEED, Sch Med, Exeter, Devon, England.4 aut
700a Iperen, Ev4 aut
700a Faire, Ud4 aut
700a Harst, Pvd4 aut
710a University of Oxfordb Catholic University of Leuven4 org
773t Nature Communicationsd : Nature Publishing Groupg 12:1q 12:1x 2041-1723
856u https://doi.org/10.1038/s41467-020-19366-9y Fulltext
856u https://umu.diva-portal.org/smash/get/diva2:1530434/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://www.nature.com/articles/s41467-020-19366-9.pdf
856u http://dx.doi.org/10.1038/s41467-020-19366-9x freey FULLTEXT
856u https://uu.diva-portal.org/smash/get/diva2:1535614/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180686
8564 8u https://doi.org/10.1038/s41467-020-19366-9
8564 8u https://lup.lub.lu.se/record/552b88a0-b694-4dd6-afd2-b25ccd8b584f
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435757
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:145710860

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