Vascular cognitive impairment

The term vascular cognitive impairment (VCI) was introduced around the start of the new millennium and refers to the contribution of vascular pathology to any severity of cognitive impairment, ranging from subjective cognitive decline and mild cognitive impairment to dementia. Although vascular pathology is common in elderly individuals with cognitive decline, pure vascular dementia (that is, dementia caused solely by vascular pathology) is uncommon. Indeed, most patients with vascular dementia also have other types of pathology, the most common of which is Alzheimer disease (specifically, the diffuse accumulation of amyloid-beta plaques and neurofibrillary tangles composed of tau). At present, the main treatment for VCI is prevention by treating vascular diseases and other risk factors for VCI, such as hypertension and diabetes mellitus. Despite the current paucity of disease-modifying pharmacological treatments, we foresee that eventually, we might be able to target specific brain diseases to prevent cognitive decline and dementia.

Skoog, Ingmar,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology,Centre for Ageing and Health (Agecap)(Swepub:gu)xskooi (author)
Schneider, J. A. (author)
Pantoni, L. (author)
Mok, V. (author)
Chen, C. L. H. (author)
Scheltens, P. (author)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

In:Nature Reviews Disease Primers: Springer Science and Business Media LLC42056-676X

By the author/editor: van der Flier, W ...; Skoog, Ingmar, 1 ...; Schneider, J. A.; Pantoni, L.; Mok, V.; Chen, C. L. H.; show more...; Scheltens, P.; show less...

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