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Sökning: (WFRF:(Posthuma D)) srt2:(2015-2019) > (2017) > Genome-wide associa...

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FältnamnIndikatorerMetadata
00004975naa a2200673 4500
001oai:hhs.se:1155078830006056
003SwePub
008221125s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:136091607
0247 a https://research.hhs.se/esploro/outputs/journalArticle/Genome-wide-association-meta-analysis-of-78308-individuals/9910014805699060562 URI
0247 a https://doi.org/10.1038/ng.38692 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360916072 URI
040 a (SwePub)hhsd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Johannesson, Magnusu Stockholm School of Economics,Handelshögskolan i Stockholm4 aut0 (Swepub:hhs)198@hhs.se
2451 0a Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
264 c 2017-05-22
264 1b Nature Research (part of Springer Nature),c 2017
520 a Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P −8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P −6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10−6). Despite the well-known difference in twin-based heritability2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10−29). These findings provide new insight into the genetic architecture of intelligence.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Cesarini, Davidu Center for Experimental Social Science4 aut
7001 a Koellinger, Philipp D.u Erasmus School of Economics (NL)4 aut
7001 a Magnusson, Patrik K. E.u Karolinska Institutet,Karolinska Institutet (SE),King's College London (GB)4 aut
7001 a Okbay, Aysuu Erasmus School of Economics (NL)4 aut
7001 a Rietveld, Cornelius A.u Erasmus University (NL)4 aut
7001 a Tiemeier, Henningu Erasmus University (NL)4 aut
7001 a Sniekers, Suzanneu VU University (NL)4 aut
7001 a Stringer, Svenu VU University (NL)4 aut
7001 a Watanabe, Kyokou VU University (NL)4 aut
7001 a Jansen, Phillip R.u VU University (NL)4 aut
7001 a Coleman, Jonathan R. I.u King's College London (GB)4 aut
7001 a Krapohl, Evau King's College London (GB)4 aut
7001 a Taskesen, Erdoganu VU University (NL)4 aut
7001 a Hammerschlag, Anke R.u VU University (NL)4 aut
7001 a Zabaneh, Delilahu King's College London (GB)4 aut
7001 a Amin, Najafu Erasmus Medical Center4 aut
7001 a Breen, Geromeu National institute of health research4 aut
7001 a Chabris, Christopher F.u Union College (US)4 aut
7001 a Iacono, William G.u University of Minnesota Twin Cities (US)4 aut
7001 a Ikram, Arfan M.u Erasmus Medical Center,University of Minnesota Twin Cities (US)4 aut
7001 a Lee, James J.u University of Minnesota Twin Cities (US)4 aut
7001 a McGue, Mattu University of Minnesota Twin Cities (US),Leiden University4 aut
7001 a Miller, Mike B.u University of Minnesota Twin Cities (US)4 aut
7001 a Ollier, William E.R.u University of Manchester (GB)4 aut
7001 a Payton, Antonyu University of Manchester (GB)4 aut
7001 a Pendleton, Neilu University of Manchester (GB)4 aut
7001 a Plomin, Robertu King's College London (GB)4 aut
7001 a van Duijn, Cornerlia M.u Leiden University4 aut
7001 a Posthuma, Danielleu VU University (NL)4 aut
7102 a Handelshögskolan i Stockholmb Stockholm School of Economics4 org
7730 t Nature Geneticsd : Nature Research (part of Springer Nature)x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc5665562?pdf=render
8564 8u https://research.hhs.se/esploro/outputs/journalArticle/Genome-wide-association-meta-analysis-of-78308-individuals/991001480569906056
8564 8u https://doi.org/10.1038/ng.3869
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:136091607

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