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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 10952naa a2202977 4500 | |
| 001 | oai:gup.ub.gu.se/282982 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:141444927 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2829822 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-019-0439-22 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1414449272 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Watson, H. J.4 aut |
| 245 | 1 0 | a Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa |
| 264 | c 2019-07-15 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness(1), affecting 0.9-4% of women and 0.3% of men(2-4), with twin-based heritability estimates of 50-60%(5). Mortality rates are higher than those in other psychiatric disorders(6), and outcomes are unacceptably poor(7). Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)(8,9) and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 653 | a ld score regression | |
| 653 | a eating-disorders | |
| 653 | a genetic correlations | |
| 653 | a polygenic | |
| 653 | a risk | |
| 653 | a comorbidity | |
| 653 | a prevalence | |
| 653 | a heritability | |
| 653 | a variants | |
| 653 | a insights | |
| 653 | a myc | |
| 653 | a Genetics & Heredity | |
| 700 | 1 | a Yilmaz, Z.4 aut |
| 700 | 1 | a Thorntont, L. M.u Karolinska Institutet4 aut |
| 700 | 1 | a Hubel, C.u Karolinska Institutet4 aut |
| 700 | 1 | a Coleman, J. R. I.4 aut |
| 700 | 1 | a Gaspar, H. A.4 aut |
| 700 | 1 | a Bryois, J.u Karolinska Institutet4 aut |
| 700 | 1 | a Adan, Roger A. H.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xadaro |
| 700 | 1 | a Leppa, V. M.u Karolinska Institutet4 aut |
| 700 | 1 | a Mattheisen, M.u Karolinska Institutet4 aut |
| 700 | 1 | a Medland, S. E.4 aut |
| 700 | 1 | a Ripke, S.4 aut |
| 700 | 1 | a Yao, S. Y.u Karolinska Institutet4 aut |
| 700 | 1 | a Giusti-Rodriguez, P.4 aut |
| 700 | 1 | a Hanscombe, K. B.4 aut |
| 700 | 1 | a Purves, K. L.u Karolinska Institutet4 aut |
| 700 | 1 | a Adan, Roger A. H.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xadaro |
| 700 | 1 | a Alfredsson, L.u Karolinska Institutet4 aut |
| 700 | 1 | a Ando, T.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Baker, J. H.4 aut |
| 700 | 1 | a Berrettini, W. H.4 aut |
| 700 | 1 | a Boehm, I.4 aut |
| 700 | 1 | a Boni, C.4 aut |
| 700 | 1 | a Perica, V. B.4 aut |
| 700 | 1 | a Buehren, K.4 aut |
| 700 | 1 | a Burghardt, R.4 aut |
| 700 | 1 | a Cassina, M.4 aut |
| 700 | 1 | a Cichon, S.4 aut |
| 700 | 1 | a Clementi, M.4 aut |
| 700 | 1 | a Cone, R. D.4 aut |
| 700 | 1 | a Courtet, P.4 aut |
| 700 | 1 | a Crow, S.4 aut |
| 700 | 1 | a Crowley, J. J.4 aut |
| 700 | 1 | a Danner, U. N.4 aut |
| 700 | 1 | a Davis, O. S. P.4 aut |
| 700 | 1 | a de Zwaan, M.4 aut |
| 700 | 1 | a Dedoussis, G.4 aut |
| 700 | 1 | a Degortes, D.4 aut |
| 700 | 1 | a DeSocio, J. E.4 aut |
| 700 | 1 | a Dick, D. M.4 aut |
| 700 | 1 | a Dikeos, D.4 aut |
| 700 | 1 | a Dina, C.4 aut |
| 700 | 1 | a Dmitrzak-Weglarz, M.4 aut |
| 700 | 1 | a Docampo, E.4 aut |
| 700 | 1 | a Duncan, L. E.4 aut |
| 700 | 1 | a Egberts, K.4 aut |
| 700 | 1 | a Ehrlich, S.4 aut |
| 700 | 1 | a Escaramis, G.4 aut |
| 700 | 1 | a Eskos, T.4 aut |
| 700 | 1 | a Estivill, X.4 aut |
| 700 | 1 | a Farmer, A.4 aut |
| 700 | 1 | a Favaro, A.4 aut |
| 700 | 1 | a Fernandez-Aranda, F.4 aut |
| 700 | 1 | a Fichter, M. M.4 aut |
| 700 | 1 | a Fischer, K.4 aut |
| 700 | 1 | a Focker, M.4 aut |
| 700 | 1 | a Foretova, L.4 aut |
| 700 | 1 | a Forstner, A. J.4 aut |
| 700 | 1 | a Forzan, M.4 aut |
| 700 | 1 | a Franklin, C. S.4 aut |
| 700 | 1 | a Gallinger, S.4 aut |
| 700 | 1 | a Giegling, I.4 aut |
| 700 | 1 | a Giuranna, J.4 aut |
| 700 | 1 | a Gonidakis, F.4 aut |
| 700 | 1 | a Gorwood, P.4 aut |
| 700 | 1 | a Mayora, M. G.4 aut |
| 700 | 1 | a Guillaume, S.4 aut |
| 700 | 1 | a Guo, Y. R.4 aut |
| 700 | 1 | a Hakonarson, H.4 aut |
| 700 | 1 | a Hatzikotoulas, K.4 aut |
| 700 | 1 | a Hauser, J.4 aut |
| 700 | 1 | a Hebebrand, J.4 aut |
| 700 | 1 | a Helder, S. G.4 aut |
| 700 | 1 | a Herms, S.4 aut |
| 700 | 1 | a Herpertz-Dahlmann, B.4 aut |
| 700 | 1 | a Herzog, W.4 aut |
| 700 | 1 | a Huckins, L. M.4 aut |
| 700 | 1 | a Hudson, J. I.4 aut |
| 700 | 1 | a Imgart, H.4 aut |
| 700 | 1 | a Inoko, H.4 aut |
| 700 | 1 | a Janout, V.4 aut |
| 700 | 1 | a Jimenez-Murcia, S.4 aut |
| 700 | 1 | a Julia, A.4 aut |
| 700 | 1 | a Kalsi, G.4 aut |
| 700 | 1 | a Kaminska, D.4 aut |
| 700 | 1 | a Kaprio, J.4 aut |
| 700 | 1 | a Karhunen, L.4 aut |
| 700 | 1 | a Karwautz, A.4 aut |
| 700 | 1 | a Kas, M. J. H.4 aut |
| 700 | 1 | a Kennedy, J. L.4 aut |
| 700 | 1 | a Keski-Rahkonen, A.4 aut |
| 700 | 1 | a Kiezebrink, K.4 aut |
| 700 | 1 | a Kim, Y. R.4 aut |
| 700 | 1 | a Klareskog, L.4 aut |
| 700 | 1 | a Klump, K. L.4 aut |
| 700 | 1 | a Knudsen, G. P. S.4 aut |
| 700 | 1 | a La Via, M. C.4 aut |
| 700 | 1 | a Le Hellard, S.4 aut |
| 700 | 1 | a Levitan, R. D.4 aut |
| 700 | 1 | a Li, D.4 aut |
| 700 | 1 | a Lilenfeld, L.u Karolinska Institutet4 aut |
| 700 | 1 | a Lin, B. D.4 aut |
| 700 | 1 | a Lissowska, J.4 aut |
| 700 | 1 | a Luykx, J.4 aut |
| 700 | 1 | a Magistretti, P. J.4 aut |
| 700 | 1 | a Maj, M.4 aut |
| 700 | 1 | a Mannik, K.4 aut |
| 700 | 1 | a Marsal, S.4 aut |
| 700 | 1 | a Marshall, C. R.4 aut |
| 700 | 1 | a Mattingsdal, M.4 aut |
| 700 | 1 | a McDevitt, S.4 aut |
| 700 | 1 | a McGuffin, P.4 aut |
| 700 | 1 | a Metspalu, A.4 aut |
| 700 | 1 | a Meulenbelt, I.4 aut |
| 700 | 1 | a Micali, N.4 aut |
| 700 | 1 | a Mitchell, K.4 aut |
| 700 | 1 | a Monteleone, A. M.4 aut |
| 700 | 1 | a Monteleone, P.4 aut |
| 700 | 1 | a Munn-Chernoff, M. A.4 aut |
| 700 | 1 | a Nacmias, B.4 aut |
| 700 | 1 | a Navratilova, M.4 aut |
| 700 | 1 | a Ntalla, I.4 aut |
| 700 | 1 | a O'Toole, J. K.4 aut |
| 700 | 1 | a Ophoff, R. A.4 aut |
| 700 | 1 | a Padyukov, L.4 aut |
| 700 | 1 | a Palotie, A.4 aut |
| 700 | 1 | a Pantel, J.4 aut |
| 700 | 1 | a Papezova, H.4 aut |
| 700 | 1 | a Pinto, D.4 aut |
| 700 | 1 | a Rabionet, R.4 aut |
| 700 | 1 | a Raevuori, A.4 aut |
| 700 | 1 | a Ramoz, N.4 aut |
| 700 | 1 | a Reichborn-Kjennerud, T.4 aut |
| 700 | 1 | a Ricca, V.4 aut |
| 700 | 1 | a Ripatti, S.4 aut |
| 700 | 1 | a Ritschel, F.4 aut |
| 700 | 1 | a Roberts, M.4 aut |
| 700 | 1 | a Rotondo, A.4 aut |
| 700 | 1 | a Rujescu, D.4 aut |
| 700 | 1 | a Rybakowski, F.4 aut |
| 700 | 1 | a Santonastaso, P.4 aut |
| 700 | 1 | a Scherag, A.4 aut |
| 700 | 1 | a Scherer, S. W.4 aut |
| 700 | 1 | a Schmidt, U.4 aut |
| 700 | 1 | a Schork, N. J.4 aut |
| 700 | 1 | a Schosser, A.4 aut |
| 700 | 1 | a Seitz, J.4 aut |
| 700 | 1 | a Slachtova, L.4 aut |
| 700 | 1 | a Slagboom, P. E.4 aut |
| 700 | 1 | a t Landt, Mctso4 aut |
| 700 | 1 | a Slopien, A.4 aut |
| 700 | 1 | a Sorbi, S.4 aut |
| 700 | 1 | a Swiatkowska, B.4 aut |
| 700 | 1 | a Szatkiewicz, J. P.4 aut |
| 700 | 1 | a Tachmazidou, I.4 aut |
| 700 | 1 | a Tenconi, E.4 aut |
| 700 | 1 | a Tortorella, A.4 aut |
| 700 | 1 | a Tozzi, F.4 aut |
| 700 | 1 | a Treasure, J.4 aut |
| 700 | 1 | a Tsitsika, A.4 aut |
| 700 | 1 | a Tyszkiewicz-Nwafor, M.4 aut |
| 700 | 1 | a Tziouvas, K.4 aut |
| 700 | 1 | a van Elbur, A. A.4 aut |
| 700 | 1 | a van Furth, E. F.4 aut |
| 700 | 1 | a Wagner, G.4 aut |
| 700 | 1 | a Walton, E.4 aut |
| 700 | 1 | a Widen, E.4 aut |
| 700 | 1 | a Zeggini, E.4 aut |
| 700 | 1 | a Zerwas, S.4 aut |
| 700 | 1 | a Zipfel, S.4 aut |
| 700 | 1 | a Bergen, A. W.4 aut |
| 700 | 1 | a Boden, J. M.4 aut |
| 700 | 1 | a Brandt, H.4 aut |
| 700 | 1 | a Crawford, S.4 aut |
| 700 | 1 | a Halmi, K. A.4 aut |
| 700 | 1 | a Horwood, L. J.4 aut |
| 700 | 1 | a Johnson, C.4 aut |
| 700 | 1 | a Kaplan, A. S.4 aut |
| 700 | 1 | a Kaye, W. H.4 aut |
| 700 | 1 | a Mitchell, J. E.4 aut |
| 700 | 1 | a Olsen, C. M.4 aut |
| 700 | 1 | a Pearson, J. F.4 aut |
| 700 | 1 | a Pedersen, N. L.4 aut |
| 700 | 1 | a Strober, M.4 aut |
| 700 | 1 | a Werge, T.4 aut |
| 700 | 1 | a Whiteman, D. C.4 aut |
| 700 | 1 | a Woodside, D. B.4 aut |
| 700 | 1 | a Stuber, G. D.4 aut |
| 700 | 1 | a Gordon, S.4 aut |
| 700 | 1 | a Grove, J.4 aut |
| 700 | 1 | a Henders, A. K.4 aut |
| 700 | 1 | a Jureus, A.4 aut |
| 700 | 1 | a Kirk, K. M.4 aut |
| 700 | 1 | a Larsen, J. T.4 aut |
| 700 | 1 | a Parker, R.4 aut |
| 700 | 1 | a Petersen, L.4 aut |
| 700 | 1 | a Jordan, J.4 aut |
| 700 | 1 | a Kennedy, M.4 aut |
| 700 | 1 | a Montgomery, G. W.4 aut |
| 700 | 1 | a Wade, T. D.4 aut |
| 700 | 1 | a Birgegard, A.u Karolinska Institutet4 aut |
| 700 | 1 | a Lichtenstein, P.4 aut |
| 700 | 1 | a Norring, C.u Karolinska Institutet4 aut |
| 700 | 1 | a Landen, M.4 aut |
| 700 | 1 | a Martin, N. G.4 aut |
| 700 | 1 | a Mortensen, P. B.4 aut |
| 700 | 1 | a Sullivan, P. F.u Karolinska Institutet4 aut |
| 700 | 1 | a Breen, G.4 aut |
| 700 | 1 | a Bulik, C. M.4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 51:8q 51:8x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc6779477?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/282982 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-019-0439-2 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141444927 |
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- Danner, U. N.
- Davis, O. S. P.
- de Zwaan, M.
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- Knudsen, G. P. S ...
- La Via, M. C.
- Le Hellard, S.
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- Schmidt, U.
- Schork, N. J.
- Schosser, A.
- Seitz, J.
- Slachtova, L.
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- Sorbi, S.
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