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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004381naa a2200493 4500
001oai:lup.lub.lu.se:7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed
003SwePub
008190215s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed2 URI
0247 a https://doi.org/10.1038/s41467-019-08528-z2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Reiling, Lindau Burnet Institute4 aut
2451 0a Targets of complement-fixing antibodies in protective immunity against malaria in children
264 c 2019-02-05
264 1b Springer Science and Business Media LLC,c 2019
520 a Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we show that complement-fixing antibodies to merozoites are more strongly correlated with protective immunity than antibodies that inhibit growth quantified using the current reference assay for merozoite vaccine evaluation. We identify merozoite targets of complement-fixing antibodies and identify antigen-specific complement-fixing antibodies that are strongly associated with protection from malaria in a longitudinal study of children. Using statistical modelling, combining three different antigens targeted by complement-fixing antibodies could increase the potential protective effect to over 95%, and we identify antigens that were common in the most protective combinations. Our findings support antibody-complement interactions against merozoite antigens as important anti-malaria immune mechanisms, and identify specific merozoite antigens for further evaluation as vaccine candidates.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Boyle, Michelle J.u Burnet Institute4 aut
7001 a White, Michael T.u Pasteur Institute4 aut
7001 a Wilson, Danny W.u Burnet Institute,University of Adelaide4 aut
7001 a Feng, Gaoqianu University of Melbourne,Burnet Institute4 aut
7001 a Weaver, Rupertu Burnet Institute4 aut
7001 a Opi, D. Herbertu Burnet Institute,Monash University4 aut
7001 a Persson, Kristina E.M.u Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Malaria och Babesia,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Malaria and Babesia,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klke-kpe
7001 a Richards, Jack S.u Burnet Institute,University of Melbourne4 aut
7001 a Siba, Peter M.u Papua New Guinea Institute of Medical Research4 aut
7001 a Fowkes, Freya J.I.u Burnet Institute,Royal Melbourne Hospital,Monash University,University of Melbourne4 aut
7001 a Takashima, Eizou Ehime University4 aut
7001 a Tsuboi, Takafumiu Ehime University4 aut
7001 a Mueller, Ivou Papua New Guinea Institute of Medical Research,Walter and Eliza Hall Institute of Medical Research,Pasteur Institute4 aut
7001 a Beeson, James G.u Royal Melbourne Hospital,Burnet Institute,University of Melbourne,Monash University4 aut
7102 a Burnet Instituteb Pasteur Institute4 org
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723
8564 u http://dx.doi.org/10.1038/s41467-019-08528-zx freey FULLTEXT
8564 u https://doi.org/10.1038/s41467-019-08528-z
8564 8u https://lup.lub.lu.se/record/7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed
8564 8u https://doi.org/10.1038/s41467-019-08528-z

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