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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002919naa a2200337 4500
001oai:prod.swepub.kib.ki.se:149632090
003SwePub
008240701s2022 | |||||||||||000 ||eng|
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1496320902 URI
024a https://doi.org/10.1136/bmjopen-2021-0504502 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Azizi, Z4 aut
2451 0a Importance of sex and gender factors for COVID-19 infection and hospitalisation: a sex-stratified analysis using machine learning in UK Biobank data
264 c 2022-05-18
264 1b BMJ,c 2022
520 a To examine sex and gender roles in COVID-19 test positivity and hospitalisation in sex-stratified predictive models using machine learning.DesignCross-sectional study.SettingUK Biobank prospective cohort.ParticipantsParticipants tested between 16 March 2020 and 18 May 2020 were analysed.Main outcome measuresThe endpoints of the study were COVID-19 test positivity and hospitalisation. Forty-two individuals’ demographics, psychosocial factors and comorbidities were used as likely determinants of outcomes. Gradient boosting machine was used for building prediction models.ResultsOf 4510 individuals tested (51.2% female, mean age=68.5±8.9 years), 29.4% tested positive. Males were more likely to be positive than females (31.6% vs 27.3%, p=0.001). In females, living in more deprived areas, lower income, increased low-density lipoprotein (LDL) to high-density lipoprotein (HDL) ratio, working night shifts and living with a greater number of family members were associated with a higher likelihood of COVID-19 positive test. While in males, greater body mass index and LDL to HDL ratio were the factors associated with a positive test. Older age and adverse cardiometabolic characteristics were the most prominent variables associated with hospitalisation of test-positive patients in both overall and sex-stratified models.ConclusionHigh-risk jobs, crowded living arrangements and living in deprived areas were associated with increased COVID-19 infection in females, while high-risk cardiometabolic characteristics were more influential in males. Gender-related factors have a greater impact on females; hence, they should be considered in identifying priority groups for COVID-19 infection vaccination campaigns.
700a Shiba, Y4 aut
700a Alipour, P4 aut
700a Maleki, F4 aut
700a Raparelli, V4 aut
700a Norris, C4 aut
700a Forghani, R4 aut
700a Pilote, L4 aut
700a El Emam, K4 aut
773t BMJ opend : BMJg 12:5, s. e050450-q 12:5<e050450-x 2044-6055
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149632090
8564 8u https://doi.org/10.1136/bmjopen-2021-050450

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