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Pro-IL-1β Is an Ear...
Pro-IL-1β Is an Early Prognostic Indicator of Severe Donor Lung Injury During Ex Vivo Lung Perfusion
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- Major, Triin (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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- Ball, Alexandra L. (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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- Stone, John P. (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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- Edge, Rebecca J. (författare)
- University of Manchester,Manchester University NHS Foundation Trust
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- Lopez-Castejon, Gloria (författare)
- University of Manchester
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- Sjöberg, Trygve (författare)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Andreasson, Anders (författare)
- Newcastle upon Tyne Hospitals NHS Trust
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- Brough, David (författare)
- University of Manchester
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- Steen, Stig (författare)
- Lund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups,Skåne University Hospital
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- Fisher, Andrew J. (författare)
- University of Newcastle upon Tyne,Newcastle upon Tyne Hospitals NHS Trust
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- Fildes, James E. (författare)
- Manchester University NHS Foundation Trust,University of Manchester
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(creator_code:org_t)
- 2021
- 2021
- Engelska 7 s.
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Ingår i: Transplantation. - 1534-6080. ; 105:4, s. 768-774
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Ex vivo lung perfusion (EVLP) is used to evaluate and recondition extended criteria donor lungs for transplantation. Interleukin-1β (IL-1β) has been identified as a prognostic indicator of nonrecovery during EVLP. This may be an effect of inflammasome activation or cellular necrosis following donation and graft preservation. Delineating the mechanism of IL-1β release is required. METHODS: The inactive intracellular precursor molecule, pro-IL-1β, was characterized along with the pro-IL-1β processing enzyme, caspase-1, in the perfusate of n = 20 human lungs that had undergone EVLP (n = 10 lungs that failed to recover and were discarded versus n = 10 lungs that reconditioned and were transplanted). In an experimental porcine model, n = 8 lungs underwent EVLP and were randomized to receive either a specific NLRP3 inflammasome inhibitor or control. RESULTS: Significant increases in pro-IL-1β and caspase-1 were observed in the perfusate from human lungs that did not recondition during EVLP compared with those that successfully reconditioned and were used for transplantation. Within the porcine EVLP, NLRP3 inflammasome inhibition reduced IL-1β within the perfusate compared with controls, but this had no impact on lung function, hemodynamics, or inflammation. CONCLUSIONS: Our data suggest that pro-IL-1β is passively released following cellular necrosis of the donor lung.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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Major, Triin
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Ball, Alexandra ...
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Stone, John P.
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Edge, Rebecca J.
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Lopez-Castejon, ...
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Sjöberg, Trygve
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Andreasson, Ande ...
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Brough, David
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Steen, Stig
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Fisher, Andrew J ...
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Fildes, James E.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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Transplantation
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Lunds universitet