Dopamine D1 receptor availability is related to social behavior: A positron emission tomography study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: (WFRF:(Stenkrona Per)) > Dopamine D1 recepto...

Details
MARC

Plaven-Sigray, PontusDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (author)

Dopamine D1 receptor availability is related to social behavior : A positron emission tomography study

Article/chapterEnglish2014

Publisher, publication year, extent ...

Elsevier BV,2014
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:su-111922
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-111922URI
https://doi.org/10.1016/j.neuroimage.2014.08.018DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-92171URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440744URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:130213025URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

AuthorCount:8;
Dysfunctional interpersonal behavior is thought to underlie a wide spectrum of psychiatric disorders; however, the neurobiological underpinnings of these behavioral disturbances are poorly understood. Previous molecular imaging studies have shown associations between striatal dopamine (DA) D2-receptor binding and interpersonal traits, such as social conformity. The objective of this study was to explore, for the first time, the role of DA D1-receptors (D1-Rs) in human interpersonal behavior. Twenty-three healthy subjects were examined using positron emission tomography and the radioligand [C-11] SCH23390, yielding D1-R binding potential values. Striatal D1-R binding was related to personality scales selected to specifically assess one dimension of interpersonal behavior, namely a combination of affiliation and dominance (i.e., the Social Desirability, Verbal Trait Aggression and Physical Trait Aggression scales from Swedish Universities Scales of Personality). An exploratory analysis was also performed for extrastriatal brain regions. D1-R binding potential values in the limbic striatum(r= .52; p= .015), associative striatum(r= .55; p= .009), and sensorimotor striatum(r= .67; p= .001) were positively related to Social Desirability scores. D1-R binding potential in the limbic striatum (r= -.51; p = .019) was negatively associated with Physical Trait Aggression scores. For extrastriatal regions, Social Desirability scores showed positive correlations in the amygdala (r = .60; p = .006) and medial frontal cortex (r= .60; p = .004). This study provides further support for the role of DA function in the expression of disaffiliative and dominant traits. Specifically, D1-R availability may serve as a marker for interpersonal behavior in humans. Associations were demonstrated for the same dimension of interpersonal behavior as for D2-R, but in the opposite direction, suggesting that the two receptor subtypes are involved in the same behavioral processes, but with different functional roles.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Positron emission tomography
Dopamine D1-receptors
Aggression
Social conformity
Affiliation
Dominance

Added entries (persons, corporate bodies, meetings, titles ...)

Gustavsson, PetterKarolinska Institutet (author)
Farde, LarsKarolinska Institutet (author)
Borg, JacquelineKarolinska Institutet (author)
Stenkrona, PerKarolinska Institutet (author)
Nyberg, LarsUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Umea Univ, Dept Integrat Med Biol, Umea Ctr Funct Brain Imaging, Umea, Sweden.;Umea Univ, Dept Radiat Sci, Umea, Sweden.(Swepub:umu)lany0001 (author)
Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institutet, Sweden,Karolinska Inst, Aging Res Ctr, Stockholm, Sweden. (author)
Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (author)
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenKarolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden. (creator_code:org_t)

Related titles

In:NeuroImage: Elsevier BV102, s. 590-5951053-81191095-9572

Internet link

Find in a library

NeuroImage (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Plaven-Sigray, P ...; Gustavsson, Pett ...; Farde, Lars; Borg, Jacqueline; Stenkrona, Per; Nyberg, Lars; show more...; Bäckman, Lars; Cervenka, Simon; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Articles in the publication: NeuroImage

By the university: Stockholm University; Umeå University; Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se