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New loci associated...
New loci associated with kidney function and chronic kidney disease
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-04-11
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-137787
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137787URI
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https://doi.org/10.1038/ng.568DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Pattaro, Cristian
(author)
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Böger, Carsten A.
(author)
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Fuchsberger, Christian
(author)
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Olden, Matthias
(author)
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Glazer, Nicole L.
(author)
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Parsa, Afshin
(author)
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Gao, Xiaoyi
(author)
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Yang, Qiong
(author)
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Smith, Albert V.
(author)
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O'Connell, Jeffrey R.
(author)
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Li, Man
(author)
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Schmidt, Helena
(author)
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Tanaka, Toshiko
(author)
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Isaacs, Aaron
(author)
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Ketkar, Shamika
(author)
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Hwang, Shih-Jen
(author)
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Johnson, Andrew D.
(author)
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Dehghan, Abbas
(author)
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Teumer, Alexander
(author)
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Pare, Guillaume
(author)
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Atkinson, Elizabeth J.
(author)
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Zeller, Tanja
(author)
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Lohman, Kurt
(author)
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Cornelis, Marilyn C.
(author)
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Probst-Hensch, Nicole M.
(author)
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Kronenberg, Florian
(author)
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Toenjes, Anke
(author)
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Hayward, Caroline
(author)
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Aspelund, Thor
(author)
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Eiriksdottir, Gudny
(author)
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Launer, Lenore J.
(author)
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Harris, Tamara B.
(author)
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Rampersaud, Evadnie
(author)
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Mitchell, Braxton D.
(author)
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Arking, Dan E.
(author)
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Boerwinkle, Eric
(author)
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Struchalin, Maksim
(author)
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Cavalieri, Margherita
(author)
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Singleton, Andrew
(author)
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Giallauria, Francesco
(author)
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Metter, Jeffrey
(author)
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de Boer, Ian H.
(author)
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Haritunians, Talin
(author)
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Lumley, Thomas
(author)
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Siscovick, David
(author)
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Psaty, Bruce M.
(author)
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Zillikens, M. Carola
(author)
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Oostra, Ben A.
(author)
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Feitosa, Mary
(author)
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Province, Michael
(author)
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de Andrade, Mariza
(author)
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Turner, Stephen T.
(author)
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Schillert, Arne
(author)
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Ziegler, Andreas
(author)
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Wild, Philipp S.
(author)
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Schnabel, Renate B.
(author)
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Wilde, Sandra
(author)
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Munzel, Thomas
(author)
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Leak, Tennille S.
(author)
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Illig, Thomas
(author)
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Klopp, Norman
(author)
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Meisinger, Christa
(author)
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Wichmann, H-Erich
(author)
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Koenig, Wolfgang
(author)
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Zgaga, Lina
(author)
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Zemunik, Tatijana
(author)
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Kolcic, Ivana
(author)
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Minelli, Cosetta
(author)
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Hu, Frank B.
(author)
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Johansson, ÅsaUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)asjoh108
(author)
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Igl, WilmarUppsala universitet,Institutionen för genetik och patologi
(author)
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Zaboli, GhazalUppsala universitet,Institutionen för genetik och patologi
(author)
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Wild, Sarah H.
(author)
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Wright, Alan F.
(author)
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Campbell, Harry
(author)
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Ellinghaus, David
(author)
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Schreiber, Stefan
(author)
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Aulchenko, Yurii S.
(author)
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Felix, Janine F.
(author)
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Rivadeneira, Fernando
(author)
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Uitterlinden, Andre G.
(author)
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Hofman, Albert
(author)
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Imboden, Medea
(author)
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Nitsch, Dorothea
(author)
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Brandstaetter, Anita
(author)
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Kollerits, Barbara
(author)
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Kedenko, Lyudmyla
(author)
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Maegi, Reedik
(author)
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Stumvoll, Michael
(author)
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Kovacs, Peter
(author)
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Boban, Mladen
(author)
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Campbell, Susan
(author)
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Endlich, Karlhans
(author)
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Voelzke, Henry
(author)
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Kroemer, Heyo K.
(author)
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Nauck, Matthias
(author)
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Voelker, Uwe
(author)
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Polasek, Ozren
(author)
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Vitart, Veronique
(author)
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Badola, Sunita
(author)
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Parker, Alexander N.
(author)
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Ridker, Paul M.
(author)
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Kardia, Sharon L. R.
(author)
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Blankenberg, Stefan
(author)
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Liu, Yongmei
(author)
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Curhan, Gary C.
(author)
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Franke, Andre
(author)
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Rochat, Thierry
(author)
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Paulweber, Bernhard
(author)
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Prokopenko, Inga
(author)
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Wang, Wei
(author)
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Gudnason, Vilmundur
(author)
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Shuldiner, Alan R.
(author)
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Coresh, Josef
(author)
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Schmidt, Reinhold
(author)
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Ferrucci, Luigi
(author)
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Shlipak, Michael G.
(author)
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van Duijn, Cornelia M.
(author)
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Borecki, Ingrid
(author)
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Kraemer, Bernhard K.
(author)
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Rudan, Igor
(author)
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Gyllensten, UlfUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)ulfgyll
(author)
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Wilson, James F.
(author)
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Witteman, Jacqueline C.
(author)
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Pramstaller, Peter P.
(author)
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Rettig, Rainer
(author)
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Hastie, Nick
(author)
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Chasman, Daniel I.
(author)
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Kao, W. H.
(author)
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Heid, Iris M.
(author)
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Fox, Caroline S.
(author)
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Uppsala universitetInstitutionen för genetik och patologi
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC42:5, s. 376-3841061-40361546-1718
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- Articles in the publication
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Nature Genetics
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Uppsala University