Sökning: (WFRF:(Theodoratou Evropi))
> (2020-2024) >
Gut microbiota-deri...
Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes : an umbrella review and updated meta-analysis
-
- Li, Doudou (författare)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
-
- Lu, Ying (författare)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
-
- Yuan, Shuai (författare)
- Karolinska Institutet
-
visa fler...
-
- Cai, Xiaxia (författare)
- Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
-
- He, Yuan (författare)
- Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China
-
- Chen, Jie (författare)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
-
- Wu, Qiong (författare)
- Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
-
- He, Di (författare)
- Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Peoples R China
-
Fang, Aiping (författare)
-
- Bo, Yacong (författare)
- Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
-
- Song, Peige (författare)
- Zhejiang Univ, Sch Publ Hlth, Hangzhou, Peoples R China.;Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou, Peoples R China
-
- Bogaert, Debby (författare)
- Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland
-
- Tsilidis, Kostas (författare)
- Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece
-
- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutrit Epidemiol, Stockholm, Sweden
-
- Yu, Huanling (författare)
- Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing, Peoples R China
-
- Zhu, Huilian (författare)
- Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Peoples R China
-
- Theodoratou, Evropi (författare)
- Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Med Res Council Inst Genet & Canc, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland
-
Zhu, Yimin (författare)
-
- Li, Xue (författare)
- Zhejiang Univ, Sch Med, Dept Big Data Hlth Sci, Sch Publ Hlth,Ctr Clin Big Data & Analyt,Affiliat, Hangzhou, Peoples R China
-
visa färre...
-
(creator_code:org_t)
- Oxford University Press, 2022
- 2022
- Engelska.
-
Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 116:1, s. 230-243
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Trimethylamine-N-oxide (TMAO) is a gut microbiota-derived metabolite produced from dietary nutrients. Many studies have discovered that circulating TMAO concentrations are linked to a wide range of health outcomes.Objectives: This study aimed to summarize health outcomes related to circulating TMAO concentrations.Methods: We searched the Embase. Medline, Web of Science, and Scopus databases from inception to 15 February, 2022 to identify and update meta-analyses examining the associations between 'TAO and multiple health outcomes. For each health outcome, we estimated the summary effect size. 95% prediction CI. between-study heterogeneity. evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate the evidence credibility of the identified associations.Results: This umbrella review identified 24 meta-analyses that investigated the association between circulating 'TAO concentrations and health outcomes including all-cause mortality, cardiovascular diseases (CVDs), diabetes mellitus (DM), cancer. and renal function. We updated these meta-analyses by including a total of 82 individual studies on 18 unique health outcomes. Among them, 14 associations were nominally significant. After evidence credibility assessment, we found 6 (33%) associations (i.e., all-cause mortality, CVD mortality, major adverse cardiovascular events, hypertension. DM, and glomerular filtration rate) to present highly suggestive evidence.Conclusions: TMAO might be a novel biomarker related to human health conditions including all-cause mortality, hypertension. CVD, DM. cancer, and kidney function. Further studies are needed to investigate whether circulating 'MAO concentrations could be an intervention target for chronic disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- umbrella review
- updated meta-analyses
- trimethylamine-N-oxide
- TMAO
- all-cause mortality
- cardiovascular disease
- hypertension
- diabetes mellitus
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Li, Doudou
-
Lu, Ying
-
Yuan, Shuai
-
Cai, Xiaxia
-
He, Yuan
-
Chen, Jie
-
visa fler...
-
Wu, Qiong
-
He, Di
-
Fang, Aiping
-
Bo, Yacong
-
Song, Peige
-
Bogaert, Debby
-
Tsilidis, Kostas
-
Larsson, Susanna ...
-
Yu, Huanling
-
Zhu, Huilian
-
Theodoratou, Evr ...
-
Zhu, Yimin
-
Li, Xue
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet