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Genome-wide associa...
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
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- Ferreira, MA (author)
- QIMR Berghofer Medical Research Institute
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Gamazon, ER (author)
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Al-Ejeh, F (author)
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show more...
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Aittomaki, K (author)
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Andrulis, IL (author)
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Anton-Culver, H (author)
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Arason, A (author)
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Arndt, V (author)
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Aronson, KJ (author)
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Arun, BK (author)
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Asseryanis, E (author)
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Azzollini, J (author)
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Balmana, J (author)
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Barnes, DR (author)
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Barrowdale, D (author)
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Beckmann, MW (author)
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Behrens, S (author)
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Benitez, J (author)
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Bermisheva, M (author)
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Bialkowska, K (author)
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Blomqvist, C (author)
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Bogdanova, N (author)
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Bojesen, SE (author)
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Bolla, MK (author)
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,Skåne University Hospital
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Brauch, H (author)
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Brenner, H (author)
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Broeks, A (author)
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Burwinkel, B (author)
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Caldes, T (author)
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Caligo, MA (author)
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Campa, D (author)
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Campbell, I (author)
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Canzian, F (author)
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Carter, J (author)
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Carter, BD (author)
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Castelao, JE (author)
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Chang-Claude, J (author)
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Chanock, SJ (author)
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Christiansen, H (author)
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Chung, WK (author)
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Claes, KBM (author)
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Clarke, CL (author)
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Couch, FJ (author)
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Cox, A (author)
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Cross, SS (author)
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- Czene, K (author)
- Karolinska Institutet
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Daly, MB (author)
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de la Hoya, M (author)
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Dennis, J (author)
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Devilee, P (author)
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Diez, O (author)
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Dork, T (author)
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Dunning, AM (author)
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Dwek, M (author)
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Eccles, DM (author)
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Ejlertsen, B (author)
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- Ellberg, Carolina (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Engel, C (author)
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- Eriksson, M (author)
- Karolinska Institutet
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Fasching, PA (author)
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Fletcher, O (author)
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Flyger, H (author)
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Friedman, E (author)
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Frost, D (author)
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- Gabrielson, M (author)
- Karolinska Institutet
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Gago-Dominguez, M (author)
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Ganz, PA (author)
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Gapstur, SM (author)
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Garber, J (author)
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Garcia-Closas, M (author)
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Garcia-Saenz, JA (author)
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Gaudet, MM (author)
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Giles, GG (author)
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Glendon, G (author)
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Godwin, AK (author)
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Goldberg, MS (author)
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Goldgar, DE (author)
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Gonzalez-Neira, A (author)
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Greene, MH (author)
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Gronwald, J (author)
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Guenel, P (author)
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Haiman, CA (author)
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- Hall, P (author)
- Karolinska Institutet
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Hamann, U (author)
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- He, W (author)
- Karolinska Institutet
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Heyworth, J (author)
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Hogervorst, FBL (author)
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Hollestelle, A (author)
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Hoover, RN (author)
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Hopper, JL (author)
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Hulick, PJ (author)
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- Humphreys, K (author)
- Karolinska Institutet
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Imyanitov, EN (author)
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Isaacs, C (author)
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Jakimovska, M (author)
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Jakubowska, A (author)
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James, PA (author)
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Janavicius, R (author)
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Jankowitz, RC (author)
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John, EM (author)
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Johnson, N (author)
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Joseph, V (author)
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Karlan, BY (author)
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Khusnutdinova, E (author)
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Kiiski, J (author)
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Ko, YD (author)
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Jones, ME (author)
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Konstantopoulou, I (author)
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Kristensen, VN (author)
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Laitman, Y (author)
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Lambrechts, D (author)
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Lazaro, C (author)
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Leslie, G (author)
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Lester, J (author)
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Lesueur, F (author)
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Lindstrom, S (author)
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Long, JR (author)
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Loud, JT (author)
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Lubinski, J (author)
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Makalic, E (author)
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Mannermaa, A (author)
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Manoochehri, M (author)
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- Margolin, S (author)
- Karolinska Institutet
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Maurer, T (author)
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Mavroudis, D (author)
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McGuffog, L (author)
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Meindl, A (author)
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Menon, U (author)
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Michailidou, K (author)
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Miller, A (author)
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Montagna, M (author)
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Moreno, F (author)
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Moserle, L (author)
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Mulligan, AM (author)
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Nathanson, KL (author)
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Neuhausen, SL (author)
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Nevanlinna, H (author)
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Nevelsteen, I (author)
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Nielsen, FC (author)
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Nikitina-Zake, L (author)
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Nussbaum, RL (author)
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Offit, K (author)
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Olah, E (author)
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Olopade, O (author)
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- Olsson, Håkan (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital
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Osorio, A (author)
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Papp, J (author)
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Park-Simon, TW (author)
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Parsons, MT (author)
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Pedersen, IS (author)
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Peixoto, A (author)
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Peterlongo, P (author)
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Pharoah, PDP (author)
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Plaseska-Karanfilska, D (author)
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Poppe, B (author)
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Presneau, N (author)
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Radice, P (author)
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- Rantala, J (author)
- Karolinska Institutet
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Rennert, G (author)
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Risch, HA (author)
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Saloustros, E (author)
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Sanden, K (author)
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Sawyer, EJ (author)
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Schmidt, MK (author)
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Schmutzler, RK (author)
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Sharma, P (author)
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Shu, XO (author)
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Simard, J (author)
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Singer, CF (author)
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Soucy, P (author)
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Southey, MC (author)
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Spinelli, JJ (author)
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Spurdle, AB (author)
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Stone, J (author)
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Swerdlow, AJ (author)
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Tapper, WJ (author)
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Taylor, JA (author)
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Teixeira, MR (author)
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Terry, MB (author)
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Teule, A (author)
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Thomassen, M (author)
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Thone, K (author)
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Thull, DL (author)
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Tischkowitz, M (author)
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Toland, AE (author)
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Torres, D (author)
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Truong, T (author)
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Tung, N (author)
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Vachon, CM (author)
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van Asperen, CJ (author)
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van den Ouweland, AMW (author)
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van Rensburg, EJ (author)
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Vega, A (author)
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Viel, A (author)
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Wang, Q (author)
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Wappenschmidt, B (author)
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Weitzel, JN (author)
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- Wendt, C (author)
- Karolinska Institutet
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Winqvist, R (author)
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Yang, XHR (author)
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Yannoukakos, D (author)
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Ziogas, A (author)
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Kraft, P (author)
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Antoniou, AC (author)
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Zheng, W (author)
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Easton, DF (author)
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Milne, RL (author)
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Beesley, J (author)
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Chenevix-Trench, G (author)
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Arnold, N (author)
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Auber, B (author)
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Bogdanova-Markov, N (author)
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Borde, J (author)
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Caliebe, A (author)
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Ditsch, N (author)
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Dworniczak, B (author)
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Engert, S (author)
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Faust, U (author)
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Gehrig, A (author)
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Hahnen, E (author)
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Hauke, J (author)
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Hentschel, J (author)
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Herold, N (author)
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Honisch, E (author)
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Just, W (author)
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Kast, K (author)
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Larsen, M (author)
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Lemke, J (author)
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Nguyen, HP (author)
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Niederacher, D (author)
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Ott, CE (author)
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Platzer, K (author)
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Pohl-Rescigno, E (author)
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Ramser, J (author)
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Rhiem, K (author)
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Steinemann, D (author)
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Sutter, C (author)
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Varon-Mateeva, R (author)
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Wang-Gohrke, S (author)
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Weber, BHF (author)
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Prieur, F (author)
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Pujol, P (author)
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Sagne, C (author)
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Sevenet, N (author)
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Sobol, H (author)
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Sokolowska, J (author)
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Stoppa-Lyonnet, D (author)
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Venat-Bouvet, L (author)
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Adlard, J (author)
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Ahmed, M (author)
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Barwell, J (author)
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Brady, A (author)
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Brewer, C (author)
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Cook, J (author)
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Davidson, R (author)
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Donaldson, A (author)
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Eason, J (author)
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Eeles, R (author)
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Evans, DG (author)
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Gregory, H (author)
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Hanson, H (author)
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Henderson, A (author)
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Hodgson, S (author)
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Izatt, L (author)
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Kennedy, MJ (author)
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Lalloo, F (author)
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Miller, C (author)
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Morrison, PJ (author)
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Ong, KR (author)
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Perkins, J (author)
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Porteous, ME (author)
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Rogers, MT (author)
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Side, LE (author)
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Snape, K (author)
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Walker, L (author)
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Harrington, PA (author)
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Heemskerk-Gerritsen, BAM (author)
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Rookus, MA (author)
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Seynaeve, CM (author)
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van der Baan, FH (author)
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van der Hout, AH (author)
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van der Kolk, LE (author)
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van der Luijt, RB (author)
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van Deurzen, CHM (author)
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van Doorn, HC (author)
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van Engelen, K (author)
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van Hest, L (author)
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van Os, TAM (author)
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Verhoef, S (author)
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Vogel, MJ (author)
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Wijnen, JT (author)
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Miron, A (author)
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Kapuscinski, M (author)
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Bane, A (author)
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Ross, E (author)
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Buys, SS (author)
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Conner, TA (author)
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Balleine, R (author)
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Baxter, R (author)
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Braye, S (author)
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Carpenter, J (author)
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Dahlstrom, J (author)
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Forbes, J (author)
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Lee, SC (author)
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Marsh, D (author)
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Morey, A (author)
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Pathmanathan, N (author)
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Simpson, P (author)
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Spigelman, A (author)
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Wilcken, N (author)
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Yip, D (author)
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(creator_code:org_t)
- 2019-04-15
- 2019
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1741-
- Related links:
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ferreira, MA
-
Gamazon, ER
-
Al-Ejeh, F
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Aittomaki, K
-
Andrulis, IL
-
Anton-Culver, H
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show more...
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Arason, A
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Arndt, V
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Aronson, KJ
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Arun, BK
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Asseryanis, E
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Azzollini, J
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Balmana, J
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Barnes, DR
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Barrowdale, D
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Beckmann, MW
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Behrens, S
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Benitez, J
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Bermisheva, M
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Bialkowska, K
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Blomqvist, C
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Bogdanova, N
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Bojesen, SE
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Bolla, MK
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Borg, Åke
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Brauch, H
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Brenner, H
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Broeks, A
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Burwinkel, B
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Caldes, T
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Caligo, MA
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Campa, D
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Campbell, I
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Canzian, F
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Carter, J
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Carter, BD
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Castelao, JE
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Chang-Claude, J
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Chanock, SJ
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Christiansen, H
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Chung, WK
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Claes, KBM
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Clarke, CL
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Couch, FJ
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Cox, A
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Cross, SS
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Czene, K
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Daly, MB
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de la Hoya, M
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Dennis, J
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Devilee, P
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Diez, O
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Dork, T
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Dunning, AM
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Dwek, M
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Eccles, DM
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Ejlertsen, B
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Ellberg, Carolin ...
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Engel, C
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Eriksson, M
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Fasching, PA
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Fletcher, O
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Flyger, H
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Friedman, E
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Frost, D
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Gabrielson, M
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Gago-Dominguez, ...
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Ganz, PA
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Gapstur, SM
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Garber, J
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Garcia-Closas, M
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Garcia-Saenz, JA
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Gaudet, MM
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Giles, GG
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Glendon, G
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Godwin, AK
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Goldberg, MS
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Goldgar, DE
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Gonzalez-Neira, ...
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Greene, MH
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Gronwald, J
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Guenel, P
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Haiman, CA
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Hall, P
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Hamann, U
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He, W
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Heyworth, J
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Hogervorst, FBL
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Hollestelle, A
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Hoover, RN
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Hopper, JL
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Hulick, PJ
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Humphreys, K
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Imyanitov, EN
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Isaacs, C
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Jakimovska, M
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Jakubowska, A
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James, PA
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Janavicius, R
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Jankowitz, RC
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John, EM
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Johnson, N
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Joseph, V
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Karlan, BY
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Khusnutdinova, E
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Kiiski, J
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Ko, YD
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Jones, ME
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Konstantopoulou, ...
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Kristensen, VN
-
Laitman, Y
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Lambrechts, D
-
Lazaro, C
-
Leslie, G
-
Lester, J
-
Lesueur, F
-
Lindstrom, S
-
Long, JR
-
Loud, JT
-
Lubinski, J
-
Makalic, E
-
Mannermaa, A
-
Manoochehri, M
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Margolin, S
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Maurer, T
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Mavroudis, D
-
McGuffog, L
-
Meindl, A
-
Menon, U
-
Michailidou, K
-
Miller, A
-
Montagna, M
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Moreno, F
-
Moserle, L
-
Mulligan, AM
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Nathanson, KL
-
Neuhausen, SL
-
Nevanlinna, H
-
Nevelsteen, I
-
Nielsen, FC
-
Nikitina-Zake, L
-
Nussbaum, RL
-
Offit, K
-
Olah, E
-
Olopade, O
-
Olsson, Håkan
-
Osorio, A
-
Papp, J
-
Park-Simon, TW
-
Parsons, MT
-
Pedersen, IS
-
Peixoto, A
-
Peterlongo, P
-
Pharoah, PDP
-
Plaseska-Karanfi ...
-
Poppe, B
-
Presneau, N
-
Radice, P
-
Rantala, J
-
Rennert, G
-
Risch, HA
-
Saloustros, E
-
Sanden, K
-
Sawyer, EJ
-
Schmidt, MK
-
Schmutzler, RK
-
Sharma, P
-
Shu, XO
-
Simard, J
-
Singer, CF
-
Soucy, P
-
Southey, MC
-
Spinelli, JJ
-
Spurdle, AB
-
Stone, J
-
Swerdlow, AJ
-
Tapper, WJ
-
Taylor, JA
-
Teixeira, MR
-
Terry, MB
-
Teule, A
-
Thomassen, M
-
Thone, K
-
Thull, DL
-
Tischkowitz, M
-
Toland, AE
-
Torres, D
-
Truong, T
-
Tung, N
-
Vachon, CM
-
van Asperen, CJ
-
van den Ouweland ...
-
van Rensburg, EJ
-
Vega, A
-
Viel, A
-
Wang, Q
-
Wappenschmidt, B
-
Weitzel, JN
-
Wendt, C
-
Winqvist, R
-
Yang, XHR
-
Yannoukakos, D
-
Ziogas, A
-
Kraft, P
-
Antoniou, AC
-
Zheng, W
-
Easton, DF
-
Milne, RL
-
Beesley, J
-
Chenevix-Trench, ...
-
Arnold, N
-
Auber, B
-
Bogdanova-Markov ...
-
Borde, J
-
Caliebe, A
-
Ditsch, N
-
Dworniczak, B
-
Engert, S
-
Faust, U
-
Gehrig, A
-
Hahnen, E
-
Hauke, J
-
Hentschel, J
-
Herold, N
-
Honisch, E
-
Just, W
-
Kast, K
-
Larsen, M
-
Lemke, J
-
Nguyen, HP
-
Niederacher, D
-
Ott, CE
-
Platzer, K
-
Pohl-Rescigno, E
-
Ramser, J
-
Rhiem, K
-
Steinemann, D
-
Sutter, C
-
Varon-Mateeva, R
-
Wang-Gohrke, S
-
Weber, BHF
-
Prieur, F
-
Pujol, P
-
Sagne, C
-
Sevenet, N
-
Sobol, H
-
Sokolowska, J
-
Stoppa-Lyonnet, ...
-
Venat-Bouvet, L
-
Adlard, J
-
Ahmed, M
-
Barwell, J
-
Brady, A
-
Brewer, C
-
Cook, J
-
Davidson, R
-
Donaldson, A
-
Eason, J
-
Eeles, R
-
Evans, DG
-
Gregory, H
-
Hanson, H
-
Henderson, A
-
Hodgson, S
-
Izatt, L
-
Kennedy, MJ
-
Lalloo, F
-
Miller, C
-
Morrison, PJ
-
Ong, KR
-
Perkins, J
-
Porteous, ME
-
Rogers, MT
-
Side, LE
-
Snape, K
-
Walker, L
-
Harrington, PA
-
Heemskerk-Gerrit ...
-
Rookus, MA
-
Seynaeve, CM
-
van der Baan, FH
-
van der Hout, AH
-
van der Kolk, LE
-
van der Luijt, R ...
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van Deurzen, CHM
-
van Doorn, HC
-
van Engelen, K
-
van Hest, L
-
van Os, TAM
-
Verhoef, S
-
Vogel, MJ
-
Wijnen, JT
-
Miron, A
-
Kapuscinski, M
-
Bane, A
-
Ross, E
-
Buys, SS
-
Conner, TA
-
Balleine, R
-
Baxter, R
-
Braye, S
-
Carpenter, J
-
Dahlstrom, J
-
Forbes, J
-
Lee, SC
-
Marsh, D
-
Morey, A
-
Pathmanathan, N
-
Simpson, P
-
Spigelman, A
-
Wilcken, N
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Yip, D
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Lund University