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Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer : Associations with Treatment and Inflammatory Response
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- Christou, Constantina (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Tiblom Ehrsson, Ylva (författare)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Westerbergh, Johan (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- (creator_code:org_t)
- 2022-07-29
- 2022
- Engelska.
- Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:15
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Simple Summary Cancer-associated malnutrition affects nutrient metabolism, including the metabolism of lipids. Toxicities associated with the treatment for head and neck cancer (HNC) may contribute to malnutrition through impaired oral intake and inflammation. Studies on lipid metabolism in patients with HNC are very limited. The anti-inflammatory effect of some fatty acids (FAs) is already proven in other cancers but the results of these studies in HNC are not consistent. This prospective study of 174 patients with HNC contributes to our knowledge of alterations in lipid metabolism following treatment for HNC and serves as basis for future research. Studies on fatty acids (FAs) in patients with head and neck cancer (HNC) are limited. We aimed to investigate the longitudinal changes of circulating FAs in patients with HNC and to examine potential correlations of FA changes with treatment. The secondary aims were to investigate correlations of FAs with cytokines and patient-related factors, and if any FAs correlated with disease recurrence or death. A total of 174 patients with HNC were included before treatment and followed-up at three time points after the start of the treatment through blood sampling and body weight measurements. Serum FA profiling was assessed by gas chromatography. The total follow-up time was 3 years. The levels of almost all FAs changed from baseline to 7 weeks. The change in FA 14:0 was associated with treatment and the change in 18:3n-6 was associated with the patients' pre-treatment BMI. FAs 14:0 and 18:0 were correlated with weight changes from baseline to 7 weeks. IL-6 was correlated with three FAs at 7 weeks and with two FAs at 1 year. Patients with higher levels 20:5n-3 at 3 months had a higher risk of all-cause death within 3 years (HR 2.75, 95% CI 1.22-6.21). Treatment, inflammation, and weight loss contributed in a complex manner to the altered FA profile in the studied cohort. The association between IL-6 and FAs in patients with HNC is in line with earlier studies and suggests the opportunity for regulating inflammation in HNC patients through modulation of FAs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- head and neck cancer
- fatty acids
- inflammation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Christou, Consta ...
- Tiblom Ehrsson, ...
- Westerbergh, Joh ...
- Risérus, Ulf, 19 ...
- Laurell, Göran
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- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
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