Search: (hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Klinisk laboratoriemedicin)) pers:(Micke Patrick)
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Real-world prevalen...
Real-world prevalence of programmed death ligand 1 expression in locally advanced or metastatic non small-cell lung cancer : The global, multicenter EXPRESS study
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- Dietel, M. (author)
- Univ Med Berlin, Charite, Inst Pathol, Berlin, Germany
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- Savelov, N. (author)
- Moscow City Oncol Hosp 62, Dept Pathol, Moscow, Russia
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- Salanova, R. (author)
- Hosp Gastroenterol Dr Carlos Bonorino Udaondo, Dept Pathol, Buenos Aires, DF, Argentina
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- Micke, Patrick (author)
- Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
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- Bigras, G. (author)
- Univ Alberta, Cross Canc Inst, Edmonton, AB, Canada
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- Hida, T. (author)
- Aichi Canc Ctr, Dept Thorac Oncol, Nagoya, Aichi, Japan
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- Antunez, J. (author)
- Univ Hosp Santiago Compostela, Pathol Dept, La Coruna, Spain
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- Skov, B. Guldhammer (author)
- Rigshosp, Dept Pathol, Copenhagen, Denmark
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- Hutarew, G. (author)
- Univ Hosp, Inst Pathol, Salzburg, Austria;Paracelsus Med Univ Salzburg, Salzburg, Austria
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- Sua, L. F. (author)
- Fdn Valle Lili, Clin Res Ctr, Dept Pathol & Lab Med, Cali, Colombia
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- Akita, H. (author)
- Hokkaido Univ, Fac Med, Dept Med Oncol, Sapporo, Hokkaido, Japan;Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan
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- Chan, O. S. H. (author)
- Pamela Youde Nethersole Eastern Hosp, Dept Clin Oncol, Chai Wan, Hong Kong, Peoples R China
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- Piperdi, B. (author)
- Merck & Co Inc, Kenilworth, NJ USA
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- Burke, T. (author)
- Merck & Co Inc, Ctr Observat & Real World Evidence, Kenilworth, NJ USA
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- Khambata-Ford, S. (author)
- Merck & Co Inc, Kenilworth, NJ USA
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- Deitz, A. C. (author)
- Merck & Co Inc, Ctr Observat & Real World Evidence, Kenilworth, NJ USA
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Lung Cancer. - : Elsevier BV. - 0169-5002 .- 1872-8332. ; 134, s. 174-179
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- ObjectivesTumor programmed death ligand 1 (PD-L1) expression is associated with improved clinical benefit from immunotherapies targeting the PD-1 pathway. We conducted a global, multicenter, retrospective observational study to determine real-world prevalence of tumor PD-L1 expression in patients with NSCLC.Materials and methodsPatients ≥18 years with histologically confirmed stage IIIB/IV NSCLC and a tumor tissue block (≤5 years old) obtained before treatment were identified in 45 centers across 18 countries. Tumor samples from eligible patients were selected consecutively, when possible. PD-L1 expression was evaluated at each center using the PD-L1 IHC 22C3 pharmDx kit (Agilent, Santa Clara, CA, USA).ResultsOf 2617 patients who met inclusion criteria, 2368 (90%) had PD-L1 data; 530 (22%) patients had PD-L1 TPS ≥ 50%, 1232 (52%) had PD-L1 TPS ≥ 1%, and 1136 (48%) had PD-L1 TPS < 1%. The most common reason for not having PD-L1 data (n = 249) was insufficient tumor cells (<100) on the slide (n = 170 [6%]). Percentages of patients with PD-L1 TPS ≥ 50% and TPS ≥ 1%, respectively were: 22%/52% in Europe; 22%/53% in Asia Pacific; 21%/47% in the Americas, and 24%/55% in other countries. Prevalence of EGFR mutations (19%) and ALK alterations (3%) was consistent with prior reports from metastatic NSCLC studies. Among 1064 patients negative for both EGFR mutation and ALK alteration, the percentage with PD-L1 TPS ≥ 50% and TPS ≥ 1%, respectively, were 27% and 53%.ConclusionsThis is the largest real-world study in advanced NSCLC to date evaluating PD-L1 tumor expression using the 22C3 pharmDx kit. Testing failure rate was low with local evaluation of PD-L1 TPS across a large number of centers. Prevalence of PD-L1 TPS ≥ 50% and TPS ≥ 1% among patients with stage IIIB/IV NSCLC was similar across geographic regions and broadly consistent with central testing results from clinical trial screening populations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- non-small-cell lung cancer
- PD-L1
- Biomarker
- Prevalence
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dietel, M.
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Savelov, N.
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Salanova, R.
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Micke, Patrick
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Bigras, G.
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Hida, T.
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Antunez, J.
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Skov, B. Guldham ...
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Hutarew, G.
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Sua, L. F.
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Akita, H.
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Chan, O. S. H.
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Piperdi, B.
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Burke, T.
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Khambata-Ford, S ...
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Deitz, A. C.
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- MEDICAL AND HEALTH SCIENCES
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- Articles in the publication
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Lung Cancer
- By the university
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Uppsala University