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Search: (hsv:(SAMHÄLLSVETENSKAP) hsv:(Psykologi)) pers:(Nilsson Lars Göran) lar1:(liu) > Shorter telomere le...

Shorter telomere length is linked to brain atrophy and white matter hyperintensities

Wikgren, Mikael, 1981- (author)
Umeå universitet,Psykiatri,Umeå University, Sweden
Karlsson, Thomas, 1953- (author)
Linköpings universitet,Handikappvetenskap,Filosofiska fakulteten
Söderlund, Hedvig (author)
Uppsala universitet,Institutionen för psykologi,Uppsala University, Sweden
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Nordin, Annelie (author)
Umeå universitet,Psykiatri,Umeå University, Sweden
Roos, Göran (author)
Umeå universitet,Patologi,Umeå University, Sweden
Nilsson, Lars-Göran (author)
Stockholms universitet,Psykologiska institutionen,Stockholm University, Department of Psychology,Stockholm University, Sweden
Adolfsson, Rolf (author)
Umeå universitet,Psykiatri,Umeå University, Sweden
Norrback, Karl-Fredrik (author)
Umeå universitet,Psykiatri,Umeå University, Sweden
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 (creator_code:org_t)
2013-11-14
2014
English.
In: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 43:2, s. 212-217
Related links:
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https://urn.kb.se/re...
https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging. Methods: we investigated whether leukocyte TL was related to brain atrophy and WMHs in a sample of 102 non-demented individuals aged 64-75 years. Results: shorter TL was related to greater degree of subcortical atrophy (beta = -0.217, P = 0.034), but not to cortical atrophy. Furthermore, TL was 371 bp shorter (P = 0.041) in participants exhibiting subcortical WMHs, and 552 bp shorter (P = 0.009) in older participants exhibiting periventricular WMHs. Conclusion: this study provides the first evidence of leukocyte TL being associated with cerebral subcortical atrophy and WMHs, lending further support to the concept of TL as a marker of biological aging, and in particular that of the aging brain.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

brain atrophy
older people
telomere length
white matter hyperintensities

Publication and Content Type

ref (subject category)
art (subject category)

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