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Sökning: (swepub) lar1:(oru) pers:(Tysk Curt) conttype:(refereed) > Twin studies reveal...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04936naa a2200625 4500 | |
| 001 | oai:DiVA.org:oru-7014 | |
| 003 | SwePub | |
| 008 | 090528s2009 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-104832 | |
| 009 | oai:prod.swepub.kib.ki.se:118685208 | |
| 009 | oai:slubar.slu.se:25694 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70142 URI |
| 024 | 7 | a https://doi.org/10.1002/ibd.207832 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1048322 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1186852082 URI |
| 024 | 7 | a https://res.slu.se/id/publ/256942 URI |
| 040 | a (SwePub)orud (SwePub)uud (SwePub)kid (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Willing, Ben4 aut |
| 245 | 1 0 | a Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease |
| 264 | 1 | a New York :b John Wiley & Sons,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a BACKGROUND: Large interindividual variation in the composition of the intestinal microbiota between unrelated individuals has made it challenging to identify specific aspects of dysbiosis that lead to Crohn's disease (CD).METHODS: To reduce variations in exposure during establishment of the gut flora and the influence of genotype, we studied the mucosa-associated microbiota of monozygotic twin pairs that were discordant (n = 6) or concordant (n = 4) for CD. DNA was extracted from biopsies collected from 5 locations between the ileum and rectum. Bacterial 16S ribosomal RNA genes were amplified and community composition assessed by terminal-restriction fragment length polymorphism, cloning and sequencing, and quantitative real-time polymerase chain reaction (PCR).RESULTS: The microbial compositions at all biopsy locations for each individual were similar, regardless of disease state, but there were differences between individuals. In particular, individuals with predominantly ileal CD had a dramatically lower abundance (P < 0.001) of Faecalibacterium prausnitzii and increased abundance (P < 0.03) of Escherichia coli compared to healthy co-twins and those with CD localized in the colon. This dysbiosis was significantly correlated to the disease phenotype rather than genotype.CONCLUSIONS: The reduced abundance of F. prausnitzii and increased abundance of E. coli are indicative of an ileal CD phenotype, distinct from colonic CD, and the relative abundances of these specific bacterial populations are promising biomarker candidates for differential diagnosis of CD and eventually customized treatment. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 653 | a Gastroenterology | |
| 653 | a Gastroenterologi | |
| 653 | a Internal medicine | |
| 653 | a Invärtesmedicin | |
| 653 | a Medicin | |
| 653 | a Medicine | |
| 653 | a Escherichia coli | |
| 700 | 1 | a Halfvarson, Jonasu Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)jshn |
| 700 | 1 | a Dicksved, Johanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology4 aut0 (Swepub:slu)47518 |
| 700 | 1 | a Rosenquist, Magnusu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Enheten för klinisk immunologi,Institutionen för mikrobiologi,Department of Microbiology4 aut0 (Swepub:slu)51968 |
| 700 | 1 | a Järnerot, Gunnaru Örebro universitet,Hälsoakademin4 aut |
| 700 | 1 | a Engstrand, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Tysk, Curtu Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)ctk |
| 700 | 1 | a Jansson, Janetu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology4 aut0 (Swepub:slu)51483 |
| 710 | 2 | a Örebro universitetb Hälsoakademin4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t Inflammatory Bowel Diseasesd New York : John Wiley & Sonsg 15:5, s. 653-660q 15:5<653-660x 1078-0998x 1536-4844 |
| 856 | 4 | u https://digital.library.unt.edu/ark:/67531/metadc929705/m2/1/high_res_d/970049.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7014 |
| 856 | 4 8 | u https://doi.org/10.1002/ibd.20783 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104832 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118685208 |
| 856 | 4 8 | u https://res.slu.se/id/publ/25694 |
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