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Evaluation of human...
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer
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Kreimer, Aimée R (author)
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, Lyon, France
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Waterboer, Tim (author)
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show more...
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Kaaks, Rudolf (author)
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Chang-Claude, Jenny (author)
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Drogen, Dagmar (author)
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Tjønneland, Anne (author)
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Overvad, Kim (author)
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Quirós, J Ramón (author)
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González, Carlos A (author)
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Sánchez, Maria José (author)
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Larrañaga, Nerea (author)
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Navarro, Carmen (author)
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Barricarte, Aurelio (author)
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Travis, Ruth C (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Trichopoulos, Dimitrios (author)
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Peeters, Petra H M (author)
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Panico, Salvatore (author)
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Masala, Giovanna (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Bueno-de-Mesquita, H Bas (author)
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- Laurell, Göran (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning,Enheten för biobanksforskning
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- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Ekström, Johanna (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Skeie, Guri (author)
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Lund, Eiliv (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Ferrari, Pietro (author)
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Byrnes, Graham (author)
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Romieu, Isabelle (author)
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Riboli, Elio (author)
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Hildesheim, Allan (author)
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Boeing, Heiner (author)
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Pawlita, Michael (author)
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Brennan, Paul (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Journal of Clinical Oncology. - 0732-183X .- 1527-7755. ; 31:21, s. 2708-2715
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
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- PURPOSE:Human papillomavirus type 16 (HPV16) infection is causing an increasing number of oropharyngeal cancers in the United States and Europe. The aim of our study was to investigate whether HPV antibodies are associated with head and neck cancer risk when measured in prediagnostic sera.METHODS:We identified 638 participants with incident head and neck cancers (patients; 180 oral cancers, 135 oropharynx cancers, and 247 hypopharynx/larynx cancers) and 300 patients with esophageal cancers as well as 1,599 comparable controls from within the European Prospective Investigation Into Cancer and Nutrition cohort. Prediagnostic plasma samples from patients (collected, on average, 6 years before diagnosis) and control participants were analyzed for antibodies against multiple proteins of HPV16 as well as HPV6, HPV11, HPV18, HPV31, HPV33, HPV45, and HPV52. Odds ratios (ORs) of cancer and 95% CIs were calculated, adjusting for potential confounders. All-cause mortality was evaluated among patients using Cox proportional hazards regression.RESULTS:HPV16 E6 seropositivity was present in prediagnostic samples for 34.8% of patients with oropharyngeal cancer and 0.6% of controls (OR, 274; 95% CI, 110 to 681) but was not associated with other cancer sites. The increased risk of oropharyngeal cancer among HPV16 E6 seropositive participants was independent of time between blood collection and diagnosis and was observed more than 10 years before diagnosis. The all-cause mortality ratio among patients with oropharyngeal cancer was 0.30 (95% CI, 0.13 to 0.67), for patients who were HPV16 E6 seropositive compared with seronegative.CONCLUSION:HPV16 E6 seropositivity was present more than 10 years before diagnosis of oropharyngeal cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kreimer, Aimée R
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Johansson, Matti ...
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Waterboer, Tim
-
Kaaks, Rudolf
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Chang-Claude, Je ...
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Drogen, Dagmar
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show more...
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Tjønneland, Anne
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Overvad, Kim
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Quirós, J Ramón
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González, Carlos ...
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Sánchez, Maria J ...
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Larrañaga, Nerea
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Navarro, Carmen
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Barricarte, Aure ...
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Travis, Ruth C
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Khaw, Kay-Tee
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Wareham, Nick
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Trichopoulou, An ...
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Lagiou, Pagona
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Trichopoulos, Di ...
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Peeters, Petra H ...
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Panico, Salvator ...
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Masala, Giovanna
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Grioni, Sara
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Tumino, Rosario
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Vineis, Paolo
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Bueno-de-Mesquit ...
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Laurell, Göran
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Hallmans, Göran
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Manjer, Jonas
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Ekström, Johanna
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Skeie, Guri
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Lund, Eiliv
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Weiderpass, Elis ...
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Ferrari, Pietro
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Byrnes, Graham
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Romieu, Isabelle
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Riboli, Elio
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Hildesheim, Alla ...
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Boeing, Heiner
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Pawlita, Michael
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Brennan, Paul
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University
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Umeå University
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Lund University
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Karolinska Institutet