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Adult weight change...
Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women
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- Schoemaker, Minouk J. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England.
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- Nichols, Hazel B. (author)
- Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.
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- Wright, Lauren B. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England.,Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
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- Brook, Mark N. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England.
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- Jones, Michael E. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England.
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- O'Brien, Katie M. (author)
- NIEHS, Biostat & Computat Biol Branch, NIH, Durham, NC USA.
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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Baglietto, Laura (author)
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- Bernstein, Leslie (author)
- Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA.
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- Bertrand, Kimberly A. (author)
- Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
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- Boutron-Ruault, Marie-Christine (author)
- Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
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- Chen, Yu (author)
- NYU, Sch Med, Dept Populat Hlth, New York, NY USA.;NYU, Sch Med, Perlmutter Canc Ctr, New York, NY USA.
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- Connor, Avonne E. (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.
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- Dossus, Laure (author)
- Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France.
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- Eliassen, A. Heather (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Giles, Graham G. (author)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia.
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- Gram, Inger T. (author)
- Univ Tromso UiT, Dept Community Med, Fac Hlth Sci, Tromso, Norway.
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- Hankinson, Susan E. (author)
- Univ Massachusetts, Dept Biostat & Epidemiol, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA.
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- Kaaks, Rudolf (author)
- DKFZ, Div Canc Epidemiol, Heidelberg, Germany.
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- Key, Timothy J. (author)
- Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
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- Kirsh, Victoria A. (author)
- Ontario Inst Canc Res, Toronto, ON, Canada.
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- Kitahara, Cari M. (author)
- NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Larsson, Susanna C. (author)
- Karolinska Institutet
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- Linet, Martha (author)
- NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
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- Ma, Huiyan (author)
- Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA USA.
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- Milne, Roger L. (author)
- Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia.
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- Ozasa, Kotaro (author)
- Radiat Effects Res Fdn, Hiroshima, Japan.
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- Palmer, Julie R. (author)
- Boston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USA.
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- Riboli, Elio (author)
- Imperial Coll, Sch Publ Hlth, London, England.
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- Rohan, Thomas E. (author)
- Albert Einstein Coll Med, Bronx, NY 10467 USA.
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- Sacerdote, Carlotta (author)
- Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy.;Ctr Canc Prevent CPO, Turin, Italy.
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- Sadakane, Atsuko (author)
- Radiat Effects Res Fdn, Hiroshima, Japan.
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- Sund, Malin (author)
- Umeå universitet,Kirurgi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
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- Tamimi, Rulla M. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Trichopoulou, Antonia (author)
- Hellen Hlth Fdn, Athens, Greece.
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- Ursin, Giske (author)
- Inst Populat Based Canc Res, Canc Registry Norway, Oslo, Norway.;Univ Oslo, Inst Basic Med Sci, Oslo, Norway.;Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA.
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- Visvanathan, Kala (author)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Johns Hopkins Sch Med, Baltimore, MD USA.
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- Weiderpass, Elisabete (author)
- WHO, IARC, Lyon, France.
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- Willett, Walter C. (author)
- Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Zeleniuch-Jacquotte, Anne (author)
- NYU, Sch Med, Dept Populat Hlth, New York, NY USA.;NYU, Sch Med, Perlmutter Canc Ctr, New York, NY USA.
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- Sandler, Dale P. (author)
- NIEHS, Epidemiol Branch, NIH, Durham, NC USA.
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- Swerdlow, Anthony J. (author)
- Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England.
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Inst Canc Res, Div Genet & Epidemiol, London, England Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA. (creator_code:org_t)
- 2020-02-15
- 2020
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 147:5, s. 1306-1314
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Abstract
Subject headings
Close
- Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast neoplasms
- premenopause
- body weight changes
- risk factors
- cohort studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Schoemaker, Mino ...
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Nichols, Hazel B ...
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Wright, Lauren B ...
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Brook, Mark N.
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Jones, Michael E ...
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O'Brien, Katie M ...
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show more...
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Adami, Hans-Olov
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Baglietto, Laura
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Bernstein, Lesli ...
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Bertrand, Kimber ...
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Boutron-Ruault, ...
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Chen, Yu
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Connor, Avonne E ...
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Dossus, Laure
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Eliassen, A. Hea ...
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Giles, Graham G.
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Gram, Inger T.
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Hankinson, Susan ...
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Kaaks, Rudolf
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Key, Timothy J.
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Kirsh, Victoria ...
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Kitahara, Cari M ...
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Larsson, Susanna ...
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Linet, Martha
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Ma, Huiyan
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Milne, Roger L.
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Ozasa, Kotaro
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Palmer, Julie R.
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Riboli, Elio
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Rohan, Thomas E.
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Sacerdote, Carlo ...
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Sadakane, Atsuko
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Sund, Malin
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Tamimi, Rulla M.
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Trichopoulou, An ...
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Ursin, Giske
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Visvanathan, Kal ...
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Weiderpass, Elis ...
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Willett, Walter ...
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Wolk, Alicja
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Zeleniuch-Jacquo ...
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Sandler, Dale P.
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Swerdlow, Anthon ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
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Umeå University
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Uppsala University
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Karolinska Institutet