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Search: L773:0012 1797 OR L773:1939 327X > (2015-2019) > Glucagon-Like Pepti...

  • Anderberg, Rozita H,1976Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology (author)

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-01-05
  • American Diabetes Association,2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/260354
  • https://gup.ub.gu.se/publication/260354URI
  • https://doi.org/10.2337/db16-0755DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Glucagon-like peptide 1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as antiobesity strategies. Surprisingly, whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-1 and serotonin interact at the level of the central nervous system. Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin turnover and expression of 5-hydroxytryptamine (5-HT) 2A (5-HT2A) and 5-HT2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. We demonstrate that the 5-HT2A, but surprisingly not the 5-HT2C, receptor is critical for weight loss, anorexia, and fat mass reduction induced by central GLP-1R activation. Importantly, central 5-HT2A receptors are also required for peripherally injected liraglutide to reduce feeding and weight. Dorsal raphe (DR) harbors cell bodies of serotonin-producing neurons that supply serotonin to the hypothalamic nuclei. We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase the electrical activity of the DR serotonin neurons. Finally, our results disassociate brain metabolic and emotionality pathways impacted by GLP-1R activation. This study identifies serotonin as a new critical neural substrate for GLP-1 impact on energy homeostasis and expands the current map of brain areas impacted by GLP-1R activation.

Subject headings and genre

  • MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
  • MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
  • Aminopyridines/pharmacology
  • Animals
  • Anorexia
  • Appetite/*drug effects
  • Body Weight/*drug effects
  • Dorsal Raphe Nucleus/*metabolism
  • Feeding Behavior/drug effects
  • Fenclonine/pharmacology
  • Glucagon-Like Peptide 1/*pharmacology
  • Glucagon-Like Peptide-1 Receptor/*drug effects/metabolism
  • Hypoglycemic Agents/*pharmacology
  • Indoles/pharmacology
  • Liraglutide/pharmacology
  • Male
  • Peptides/pharmacology
  • Pyrrolidines/pharmacology
  • Rats
  • Rats
  • Sprague-Dawley
  • Receptor
  • Serotonin
  • 5-HT2A/*drug effects/metabolism
  • Receptor
  • Serotonin
  • 5-HT2C/*drug effects/metabolism
  • Serotonin/*metabolism
  • Serotonin Antagonists/pharmacology
  • Venoms/pharmacology
  • Weight Loss/drug effects

Added entries (persons, corporate bodies, meetings, titles ...)

  • Richard, Jennifer E.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xricje (author)
  • Eerola, Kim,1982Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xeerki (author)
  • López-Ferreras, LorenaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xloplo (author)
  • Banke, ElinGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xbanel (author)
  • Hansson, Caroline,1981Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xhacar (author)
  • Nissbrandt, Hans,1952Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xnisha (author)
  • Bergquist, Filip,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xberfi (author)
  • Gribble, F. M. (author)
  • Reimann, F. (author)
  • Wernstedt Asterholm, Ingrid,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xwerni (author)
  • Lamy, C. M. (author)
  • Skibicka, Karolina PGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xskika (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi (creator_code:org_t)

Related titles

  • In:Diabetes: American Diabetes Association66:4, s. 1062-10730012-17971939-327X

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