Search: L773:0014 2980 OR L773:1521 4141
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T lymphocyte expres...
T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components.
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- Li, Shu Shun (author)
- Umeå universitet,Klinisk immunologi
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- Ivanoff, Anna (author)
- Karolinska Institutet,Umeå universitet,Klinisk immunologi
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Bergström, Sten-Erik (author)
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- Sandström, Anders (author)
- Umeå universitet,Klinisk immunologi
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- Christensson, Birger (author)
- Karolinska Institutet
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van Nerven, Joost (author)
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Holgersson, Jan (author)
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- Hauzenberger, Dan (author)
- Karolinska Institutet
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- Arencibia, Ignacio (author)
- Umeå universitet,Klinisk immunologi
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- Sundqvist, Karl-Gösta (author)
- Karolinska Institutet,Umeå universitet,Klinisk immunologi
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: European Journal of Immunology. - 0014-2980 .- 1521-4141. ; 32:4, s. 1069-1079
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The mechanisms controlling the formation of pseudopodia and other active cell edges in T lymphocytes are not understood. We show here that T lymphocytes express thrombospondin-1 (TSP-1). TSP-1 in T lymphocytes has a high turnover as shown by the fact that brefeldin and monensin rapidly increase while cycloheximide tend to decrease the cellular TSP-1 content. T cell TSP-1 is preferentially stored intracellularly and shows variable cell surface expression. T lymphocyte adhesion to fibronectin and collagen type IV induces TSP-1 expression on the cell surface via a brefeldin sensitive mechanism. A monoclonal antibody to TSP-1 inhibits the flattening and pseudopodia formation of the adherent T cells. Furthermore, the same antibody to TSP-1 also exerts an inhibitory effect on T cell migration in the absence of exogenous TSP-1. These results indicate that endogenous TSP-1 is part of an adhesion-dependent mechanism controlling cytoplasmic spreading and migration in T lymphocytes.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Shu Shun
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Ivanoff, Anna
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Bergström, Sten- ...
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Sandström, Ander ...
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Christensson, Bi ...
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van Nerven, Joos ...
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show more...
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Holgersson, Jan
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Hauzenberger, Da ...
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Arencibia, Ignac ...
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Sundqvist, Karl- ...
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show less...
- Articles in the publication
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European Journal ...
- By the university
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Umeå University
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Karolinska Institutet