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Biorelevant intrins...
Biorelevant intrinsic dissolution profiling in early drug development : Fundamental, methodological, and industrial aspects
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- Bergström, Christel, 1973- (författare)
- Uppsala universitet,Institutionen för farmaci
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- Box, Karl (författare)
- PION Inc, Forest Row Business Pk, Forest Row RH18 5DW, E Sussex, England
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- Holm, Rene (författare)
- Johnson & Johnson, Janssen R&D, Drug Prod Dev, Turnhoutseweg 30, B-2340 Beerse, Belgium
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- Matthews, Wayne (författare)
- GlaxoSmith Kline Med Res Ctr, Dept Prod Dev, 2G118,Gunnels Wood Rd, Stevenage, Herts, England
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- McAllister, Mark (författare)
- Pfizer Ltd, Pharmaceut Sci, Drug Prod Design, Sandwich CT13 9NJ, Kent, England
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- Mullertz, Anette (författare)
- Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
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- Rades, Thomas (författare)
- Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen, Denmark
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- Schäfer, Kerstin J. (författare)
- Boehringer Ingelheim Pharma GmBH & Co KG, Pharmaceut Dev, Birkendorfer Str 65, D-88397 Biberach, Germany
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- Teleki, Alexandra (författare)
- Uppsala universitet,Institutionen för farmaci
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: European journal of pharmaceutics and biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 139, s. 101-114
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Intrinsic dissolution rate (IDR) is the surface specific dissolution rate of a drug. In early drug development, this property (among other parameters) is measured in order to compare different polymorphs and salt forms, guide formulation decisions, and to provide a quality marker of the active pharmaceutical ingredient (API) during production. In this review, an update on different methods and small-scale techniques that have recently evolved for determination of IDR is provided. The importance of biorelevant media and the hydrodynamic conditions of dissolution are also discussed. Different preparation techniques for samples are presented with a focus on disc, particle- and crystal-based methods. A number of small-scale techniques are then described in detail, and their applicability domains are identified. Finally, an updated industrial perspective is provided about IDR's place in the early drug development process.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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