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Injectable cell-fre...
Injectable cell-free template for bone-tissue formation
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- Bergman, Kristoffer (författare)
- Uppsala universitet,Institutionen för materialkemi,polymerkemi
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- Engstrand, Thomas (författare)
- Uppsala universitet,Polymerkemi,polymerkemi
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- Hilborn, Jöns (författare)
- Uppsala universitet,Polymerkemi,polymerkemi
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- Ossipov, Dmitri (författare)
- Uppsala universitet,Polymerkemi,polymerkemi
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- Piskounova, Sonya (författare)
- Uppsala universitet,Polymerkemi,polymerkemi
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- Bowden, Tim (författare)
- Uppsala universitet,Polymerkemi,polymerkemi
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(creator_code:org_t)
- Wiley Periodicals, Inc, 2009
- 2009
- Engelska.
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Ingår i: Journal of Biomedical Materials Research-Part A. - : Wiley Periodicals, Inc. - 1549-3296 .- 1552-4965. ; 91A:4, s. 1111-1118
- Relaterad länk:
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http://www3.intersci...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Here we present a novel injectable hydrogel which forms a template for de novo formation of bone tissue. Hydrogel formation takes place in situ in less than 1 min by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives. Endogenous cells are recruited in vivo by incorporating bone morphogenetic protein-2 (BMP-2), a powerful promoter for osteogenic differentiation. The hydrogel was evaluated in vitro by performing a cell viability test and a release study and in vivo by a rat ectopic model. Examination by X-ray, microcomputed tomography, and histology revealed a significant bone formation at the target site for gels containing BMP-2, and a complete degradation was observed for gels without BMP-2 four weeks after injection. There were no signs of inflammation or foreign body response in either group and we believe that this system has the potential as an off-the-shelf injectable to be used where bone tissue is needed.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- hydrogel
- hyaluronan
- injectable
- bone tissue engineering
- bone morphogenetic protein
- polyvinyl alcohol
- Chemistry
- Kemi
- Inorganic Chemistry
- Oorganisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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