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Effects of acutely displaced sleep on testosterone.
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- Axelsson, John (author)
- Karolinska Institutet
- Ingre, Michael (author)
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- Åkerstedt, Torbjörn (author)
- Karolinska Institutet
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- (creator_code:org_t)
- The Endocrine Society, 2005
- 2005
- English.
- In: J Clin Endocrinol Metab. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 90:8, s. 4530-5
- Journal article (peer-reviewed)
Abstract
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- CONTEXT: It is not yet clear whether the diurnal variation in testosterone is regulated by circadian or homeostatic (sleep) influences. OBJECTIVE: The present study tested whether testosterone is driven by a circadian-independent sleep effect by shifting sleep acutely to daytime in a 24-h sampling regiment. DESIGN, SETTING, AND PARTICIPANTS: In the sleep laboratory, seven healthy young men (age, 22-32 yr) participated in three conditions: habituation (sleep between 2300-0700 h), night sleep (2300-0700 h), and day sleep (0700-1500 h), the latter two in a balanced order. INTERVENTION AND MAIN OUTCOME MEASURE: Serum testosterone was, in all conditions, sampled by hourly blood drawing for 24 h during constant bed rest. RESULTS: Mean testosterone levels increased as a log-linear function of time (hours) across both sleep periods (b = 4.88; P < 0.001), from 15.3 +/- 2.1 to 25.3 +/- 2.2 nmol/liter during night sleep and from 17.3 +/- 2.1 to 26.4 +/- 2.9 nmol/liter during day sleep. Similarly, mean testosterone levels decreased with time (log-linear) awake (b = -1.80; P < 0.001). There was also evidence of a weak circadian component (acrophase ranging between 0651-0924 h) and an increase with time in the laboratory. Moreover, all these effects, except for the increase during sleep, differed significantly between individuals. CONCLUSION: In conclusion, testosterone increased during sleep and fell during waking, whereas circadian effects seemed marginal. Individual differences were pronounced.
Keyword
- Adult
- Circadian Rhythm/*physiology
- Humans
- Male
- Regression Analysis
- Research Support; Non-U.S. Gov't
- Sleep/*physiology
- Testosterone/*blood
- Wakefulness/*physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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