WFRF:(Ahlskog Nina)
Sökning: WFRF:(Ahlskog Nina) > Expression and loca...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03286naa a2200325 4500 | |
| 001 | oai:DiVA.org:umu-22420 | |
| 003 | SwePub | |
| 008 | 090507s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224202 URI |
| 024 | 7 | a https://doi.org/10.1210/en.2007-17362 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wahlberg, Patriku Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 245 | 1 0 | a Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary. |
| 264 | c 2008-06-19 | |
| 264 | 1 | b The Endocrine Society,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Proteolytic degradation of extracellular matrix components has been suggested to play an essential role in the occurrence of ovulation. Recent studies in our laboratory have indicated that the plasminogen activator and matrix metalloproteinase systems, which were previously believed to be crucial for ovulation, are not required in this process. In this study we have used a microarray approach to identify new proteases that are involved in ovulation. We found three serine proteases that were relatively highly expressed during ovulation: high-temperature requirement factor A1 (HtrA1), which was not regulated much during ovulation; serine protease 23 (PRSS23), which was down-regulated by gonadotropins; and serine protease 35 (PRSS35), which was up-regulated by gonadotropins. We have further investigated the expression patterns of these proteases during gonadotropin-induced ovulation in immature mice and in the corpus luteum (CL) of pseudopregnant mice. We found that HtrA1 was highly expressed in granulosa cells throughout follicular development and ovulation, as well as in the forming and regressing CL. PRSS23 was highly expressed in atretic follicles, and it was expressed in the ovarian stroma and theca tissues just before ovulation. PRSS35 was expressed in the theca layers of developing follicles. It was also highly induced in granulosa cells of preovulatory follicles. PRSS35 was also expressed in the forming and regressing CL. These data suggest that HtrA1 and PRSS35 may be involved in ovulation and CL formation and regression, and that PRSS23 may play a role in follicular atresia. | |
| 700 | 1 | a Nylander, Asau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 700 | 1 | a Ahlskog, Ninau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 700 | 1 | a Liu, Kuiu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)kuli0001 |
| 700 | 1 | a Ny, Toru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)tony0001 |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t Endocrinologyd : The Endocrine Societyg 149:10, s. 5070-7q 149:10<5070-7x 0013-7227x 1945-7170 |
| 856 | 4 | u https://academic.oup.com/endo/article-pdf/149/10/5070/8994526/endo5070.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22420 |
| 856 | 4 8 | u https://doi.org/10.1210/en.2007-1736 |
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- Wahlberg, Patrik
- Nylander, Asa
- Ahlskog, Nina
- Liu, Kui
- Ny, Tor
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- Endocrinology
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- Umeå universitet
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