WFRF:(Andersson Johanna)
Sökning: WFRF:(Andersson Johanna) > (2000-2004) > Fusidic acid-resist...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03734naa a2200433 4500 | |
| 001 | oai:DiVA.org:uu-47239 | |
| 003 | SwePub | |
| 008 | 081017s2003 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:1938885 | |
| 009 | oai:DiVA.org:uu-91025 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-472392 URI |
| 024 | 7 | a https://doi.org/10.1128/AAC.47.12.3743-3749.20032 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19388852 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-910252 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Macvanin, Mirjanau Karolinska Institutet,Uppsala universitet,Institutionen för cell- och molekylärbiologi4 aut |
| 245 | 1 0 | a Fusidic acid-resistant mutants of Salmonella enterica serovar Typhimurium with low fitness in vivo are defective in RpoS induction |
| 264 | 1 | c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Mutants of Salmonella enterica serovar Typhimurium resistant to fusidic acid (Fusr) have mutations in fusA, the gene encoding translation elongation factor G (EF-G). Most Fusr mutants have reduced fitness in vitro and in vivo, in part explained by mutant EF-G slowing the rate of protein synthesis and growth. However, some Fusr mutants with normal rates of protein synthesis still suffer from reduced fitness in vivo. As shown here, Fusr mutants could be similarly ranked in their relative fitness in mouse infection models, in a macrophage infection model, in their relative hypersensitivity to hydrogen peroxide in vivo and in vitro, and in the amount of RpoS production induced upon entry into the stationary phase. We identify a reduced ability to induce production of RpoS (sigmas) as a defect associated with Fusr strains. Because RpoS is a regulator of the general stress response, and an important virulence factor in Salmonella, an inability to produce RpoS in appropriate amounts can explain the low fitness of Fusr strains in vivo. The unfit Fusr mutants also produce reduced levels of the regulatory molecule ppGpp in response to starvation. Because ppGpp is a positive regulator of RpoS production, we suggest that a possible cause of the reduced levels of RpoS is the reduction in ppGpp production associated with mutant EF-G. The low fitness of Fusr mutants in vivo suggests that drugs that can alter the levels of global regulators of gene expression deserve attention as potential antimicrobial agents. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 653 | a Microbiology, immunology, infectious diseases | |
| 653 | a Mikrobiologi, immunologi, infektionssjukdomar | |
| 700 | 1 | a Björkman, Johanna4 aut |
| 700 | 1 | a Eriksson, Sofia4 aut |
| 700 | 1 | a Rhen, Mikael4 aut |
| 700 | 1 | a Andersson, Dan I4 aut |
| 700 | 1 | a Hughes, Diarmaid,d 1956-u Uppsala universitet,Institutionen för cell- och molekylärbiologi4 aut0 (Swepub:uu)diarhugh |
| 710 | 2 | a Uppsala universitetb Institutionen för cell- och molekylärbiologi4 org |
| 773 | 0 | t Antimicrobial Agents and Chemotherapyg 47:12, s. 3743-3749q 47:12<3743-3749x 0066-4804x 1098-6596 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-47239 |
| 856 | 4 8 | u https://doi.org/10.1128/AAC.47.12.3743-3749.2003 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938885 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-91025 |
Hitta via bibliotek
- Antimicrobial Agents and Chemotherapy (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Macvanin, Mirjan ...
- Björkman, Johann ...
- Eriksson, Sofia
- Rhen, Mikael
- Andersson, Dan I
- Hughes, Diarmaid ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Mikrobiologi ino ...
- Artiklar i publikationen
- Antimicrobial Ag ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
