WFRF:(Arnardóttir R. H.)
Sökning: WFRF:(Arnardóttir R. H.) > Stimulating the Res...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02801naa a2200373 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145719494 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1457194942 URI |
| 024 | 7 | a https://doi.org/10.3389/fphys.2020.6246572 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Arnardottir, Hu Karolinska Institutet4 aut |
| 245 | 1 0 | a Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial |
| 264 | c 2021-01-11 | |
| 264 | 1 | b Frontiers Media SA,c 2021 |
| 520 | a Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or “cytokine storm,” increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an “eicosanoid storm,” which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial “Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A single-blind, randomized, placebo-controlled feasibility study” (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov: NCT04647604. | |
| 700 | 1 | a Pawelzik, SCu Karolinska Institutet4 aut |
| 700 | 1 | a Wistbacka, UO4 aut |
| 700 | 1 | a Artiach, G4 aut |
| 700 | 1 | a Hofmann, Ru Karolinska Institutet4 aut |
| 700 | 1 | a Reinholdsson, I4 aut |
| 700 | 1 | a Braunschweig, Fu Karolinska Institutet4 aut |
| 700 | 1 | a Tornvall, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Religa, Du Karolinska Institutet4 aut |
| 700 | 1 | a Back, Mu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Frontiers in physiologyd : Frontiers Media SAg 11, s. 624657-q 11<624657-x 1664-042X |
| 856 | 4 | u https://www.frontiersin.org/articles/10.3389/fphys.2020.624657/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145719494 |
| 856 | 4 8 | u https://doi.org/10.3389/fphys.2020.624657 |
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