Sökning: WFRF:(Askmalm Stenmark Marie) >
Bilateral Prophylac...
Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer: A National Survey.
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- Arver, Brita (författare)
- Karolinska Institutet,Karolinska Institute
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- Isaksson, Karin (författare)
- Karolinska Institute
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- Atterhem, Hans (författare)
- Umea University Hospital
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- Baan, Annika, 2007 (författare)
- Sahlgrens University Hospital
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- Bergkvist, Leif (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala University
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- Brandberg, Yvonne (författare)
- Karolinska Institutet,Karolinska Institute
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- Ehrencrona, Hans (författare)
- Uppsala universitet,Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Medicinsk genetik,Uppsala University
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- Emanuelsson, Monica (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umea University
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- Hellborg, Henrik (författare)
- Karolinska University Hospital
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- Henriksson, Karin (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Skane University Hospital
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- Karlsson, Per, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Sahlgrens University Hospital
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- Loman, Niklas (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skane University Hospital
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- Lundberg, Jonas, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,Sahlgrens University Hospital
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- Ringberg, Anita (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skane University Hospital
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- Askmalm Stenmark, Marie (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Wickman, Marie (författare)
- Karolinska Institutet,Karolinska Institute
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- Sandelin, Kerstin (författare)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- Lippincott Williams and Wilkins; 1999, 2011
- 2011
- Engelska.
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Ingår i: Annals of surgery. - : Lippincott Williams and Wilkins; 1999. - 1528-1140 .- 0003-4932. ; 253:6, s. 1147-1154
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND/OBJECTIVE:: This study attempted a national inventory of all bilateral prophylactic mastectomies performed in Sweden between 1995 and 2005 in high-risk women without a previous breast malignancy. The primary aim was to investigate the breast cancer incidence after surgery. Secondary aims were to describe the preoperative risk assessment, operation techniques, complications, histopathological findings, and regional differences. METHODS:: Geneticists, oncologists and surgeons performing prophylactic breast surgery were asked to identify all women eligible for inclusion in their region. The medical records were reviewed in each region and the data were analyzed centrally. The BOADICEA risk assessment model was used to calculate the number of expected/prevented breast cancers during the follow-up period. RESULTS:: A total of 223 women operated on in 8 hospitals were identified. During a mean follow-up of 6.6 years, no primary breast cancer was observed compared with 12 expected cases. However, 1 woman succumbed 9 years post mastectomy to widespread adenocarcinoma of uncertain origin. Median age at operation was 40 years. A total of 58% were BRCA1/2 mutation carriers. All but 3 women underwent breast reconstruction, 208 with implants and 12 with autologous tissue. Four small, unifocal, invasive cancers and 4 ductal carcinoma in situ were found in the mastectomy specimens. The incidence of nonbreast related complications was low (3%). Implant loss due to infection/necrosis occurred in 21 women (10%) but a majority received a new implant later. In total, 64% of the women underwent at least 1unanticipated secondary operation. CONCLUSIONS:: Bilateral prophylactic mastectomy is safe and efficacious in reducing future breast cancer in asymptomatic women at high risk. Unanticipated reoperations are common. Given the small number of patients centralization seems justified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Arver, Brita
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Isaksson, Karin
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Atterhem, Hans
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Baan, Annika, 20 ...
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Bergkvist, Leif
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Brandberg, Yvonn ...
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visa fler...
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Ehrencrona, Hans
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Emanuelsson, Mon ...
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Hellborg, Henrik
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Henriksson, Kari ...
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Karlsson, Per, 1 ...
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Loman, Niklas
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Lundberg, Jonas, ...
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Ringberg, Anita
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Askmalm Stenmark ...
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Wickman, Marie
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Sandelin, Kersti ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Annals of surger ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet
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Linköpings universitet