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DOLORisk : Study pr...
DOLORisk : Study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]
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- Pascal, Mathilde M.V. (författare)
- University of Oxford
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- Themistocleous, Andreas C. (författare)
- University of Oxford
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- Baron, Ralf (författare)
- University Medical Center Schleswig-Holstein
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- Binder, Andreas (författare)
- University Medical Center Schleswig-Holstein
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- Bouhassira, Didier (författare)
- CHU Ambroise Paré,Versailles Saint-Quentin-en-Yvelines University
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- Crombez, Geert (författare)
- Ghent University
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- Finnerup, Nanna B. (författare)
- Aarhus University Hospital,Aarhus University
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- Gierthmühlen, Janne (författare)
- University Medical Center Schleswig-Holstein
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- Granovsky, Yelena (författare)
- Technion - Israel Institute of Technology
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Hebert, Harry L. (författare)
- University of Dundee
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- Jensen, Troels S. (författare)
- Aarhus University Hospital
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- Johnsen, Kristinn (författare)
- Mentis Cura EHF
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- McCarthy, Mark I. (författare)
- Wellcome Trust Centre for Human Genetics
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- Meng, Weihua (författare)
- University of Dundee
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- Palmer, Colin N.A. (författare)
- Ninewells Hospital and Medical School,University of Dundee
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- Rice, Andrew S.C. (författare)
- Imperial College London
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- Serra, Jordi (författare)
- Neuroscience Technologies S.L.P.
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- Solà, Romà (författare)
- Neuroscience Technologies S.L.P.
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- Yarnitsky, David (författare)
- Technion - Israel Institute of Technology
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- Smith, Blair H. (författare)
- University of Dundee
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- Attal, Nadine (författare)
- Versailles Saint-Quentin-en-Yvelines University,CHU Ambroise Paré
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- Bennett, David L.H. (författare)
- University of Oxford
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(creator_code:org_t)
- 2019-02-01
- 2019
- Engelska.
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Ingår i: Wellcome Open Research. - : F1000 Research Ltd. - 2398-502X. ; 3
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors. Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography. Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations. Strengths and limitations: • Large cohorts covering many possible triggers for neuropathic pain • Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors • High comparability of the data across centres thanks to harmonised protocols • One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Diabetes
- Nerve injury
- Neuropathic pain
- Neuropathy
- Pain
- Protocol
- Risk factors
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Pascal, Mathilde ...
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Themistocleous, ...
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Baron, Ralf
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Binder, Andreas
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Bouhassira, Didi ...
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Crombez, Geert
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visa fler...
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Finnerup, Nanna ...
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Gierthmühlen, Ja ...
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Granovsky, Yelen ...
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Groop, Leif
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Hebert, Harry L.
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Jensen, Troels S ...
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Johnsen, Kristin ...
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McCarthy, Mark I ...
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Meng, Weihua
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Palmer, Colin N. ...
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Rice, Andrew S.C ...
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Serra, Jordi
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Solà, Romà
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Yarnitsky, David
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Smith, Blair H.
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Attal, Nadine
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Bennett, David L ...
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