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Prediction of drug-related morphological changes of the T wave.
- Tjäderborn, Micaela (author)
- Aunes-Jansson, Maria (author)
- Samuelsson, Emma (author)
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- Frison, Lars (author)
- Johansson, S (author)
- Berggren, Anders (author)
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- (creator_code:org_t)
- 2010-04-29
- 2010
- English.
- In: Scandinavian cardiovascular journal : SCJ. - : Informa UK Limited. - 1651-2006 .- 1401-7431. ; 44:4, s. 215-22
- Journal article (peer-reviewed)
Abstract
Subject headings
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- OBJECTIVES: To describe the characteristics of patients presenting with morphological T wave changes that lead to measurement difficulties, and to identify possible predictors of such changes at baseline and early after start of treatment. DESIGN: ECGs from 145 patients receiving a combined potassium and sodium channel blocking agent for conversion of atrial fibrillation (AF), underwent semiautomatic analysis in a digitalized high-precision analysis program. In 15 patients, one or more ECGs were identified as difficult to interpret due to morphological T wave changes. They were compared with the 130 patients without such changes. RESULTS: A history of cardiac failure (p=0.027), a smaller left atrial area (p=0.010) and a longer QT(tang) minus QT(top) interval (p<0.001) at baseline was significantly more frequent as compared to the controls. Identified patients also had somewhat longer baseline QT interval duration (median QT(cB) 432 vs. 408 ms, N.S.) and a larger proportion of them were females (47% vs. 27%, N.S.). After start of infusion the QT(cB) became significantly longer in identified patients than in controls (p=0.012). CONCLUSIONS: Independent predictors of subsequent morphological changes were found at baseline and shortly after start of treatment, and may be of use to identify individuals with a reduced repolarization reserve.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Adult
- Aged
- Aged
- 80 and over
- Anti-Arrhythmia Agents
- administration & dosage
- adverse effects
- Arrhythmias
- Cardiac
- chemically induced
- physiopathology
- Atrial Fibrillation
- drug therapy
- physiopathology
- Double-Blind Method
- Electrocardiogram Pattern
- Female
- Heart Conduction System
- drug effects
- physiopathology
- Humans
- Infusions
- Parenteral
- Logistic Models
- Male
- Middle Aged
- Organic Chemicals
- administration & dosage
- adverse effects
- Potassium Channel Blockers
- administration & dosage
- adverse effects
- Predictive Value of Tests
- Risk Assessment
- Risk Factors
- Sodium Channel Blockers
- administration & dosage
- adverse effects
- Sweden
- Time Factors
- Treatment Outcome
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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