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Particle characteri...
Particle characterization and toxicity in C57BL/6 mice following instillation of five different diesel exhaust particles designed to differ in physicochemical properties
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- Bendtsen, Katja Maria (författare)
- The National Research Centre for the Working Environment
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- Gren, Louise (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Malmborg, Vilhelm Berg (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH
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visa fler...
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- Shukla, Pravesh Chandra (författare)
- Lund University,Lunds universitet,Förbränningsmotorer,Institutionen för energivetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Engines,Department of Energy Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Tunér, Martin (författare)
- Lund University,Lunds universitet,Förbränningsmotorer,Institutionen för energivetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Combustion Engines,Department of Energy Sciences,Departments at LTH,Faculty of Engineering, LTH
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Essig, Yona J. (författare)
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- Krais, Annette M. (författare)
- Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Clausen, Per Axel (författare)
- The National Research Centre for the Working Environment
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- Berthing, Trine (författare)
- The National Research Centre for the Working Environment
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- Loeschner, Katrin (författare)
- Technical University of Denmark
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- Jacobsen, Nicklas Raun (författare)
- The National Research Centre for the Working Environment
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- Wolff, Henrik (författare)
- Finnish Institute of Occupational Health
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- Pagels, Joakim (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Vogel, Ulla Birgitte (författare)
- The National Research Centre for the Working Environment,Technical University of Denmark
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(creator_code:org_t)
- 2020-08-08
- 2020
- Engelska.
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Ingår i: Particle and Fibre Toxicology. - : Springer Science and Business Media LLC. - 1743-8977. ; 17:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://particleandf...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Diesel exhaust is carcinogenic and exposure to diesel particles cause health effects. We investigated the toxicity of diesel exhaust particles designed to have varying physicochemical properties in order to attribute health effects to specific particle characteristics. Particles from three fuel types were compared at 13% engine intake O2 concentration: MK1 ultra low sulfur diesel (DEP13) and the two renewable diesel fuels hydrotreated vegetable oil (HVO13) and rapeseed methyl ester (RME13). Additionally, diesel particles from MK1 ultra low sulfur diesel were generated at 9.7% (DEP9.7) and 17% (DEP17) intake O2 concentration. We evaluated physicochemical properties and histopathological, inflammatory and genotoxic responses on day 1, 28, and 90 after single intratracheal instillation in mice compared to reference diesel particles and carbon black. RESULTS: Moderate variations were seen in physical properties for the five particles: primary particle diameter: 15-22 nm, specific surface area: 152-222 m2/g, and count median mobility diameter: 55-103 nm. Larger differences were found in chemical composition: organic carbon/total carbon ratio (0.12-0.60), polycyclic aromatic hydrocarbon content (1-27 μg/mg) and acid-extractable metal content (0.9-16 μg/mg). Intratracheal exposure to all five particles induced similar toxicological responses, with different potency. Lung particle retention was observed in DEP13 and HVO13 exposed mice on day 28 post-exposure, with less retention for the other fuel types. RME exposure induced limited response whereas the remaining particles induced dose-dependent inflammation and acute phase response on day 1. DEP13 induced acute phase response on day 28 and inflammation on day 90. DNA strand break levels were not increased as compared to vehicle, but were increased in lung and liver compared to blank filter extraction control. Neutrophil influx on day 1 correlated best with estimated deposited surface area, but also with elemental carbon, organic carbon and PAHs. DNA strand break levels in lung on day 28 and in liver on day 90 correlated with acellular particle-induced ROS. CONCLUSIONS: We studied diesel exhaust particles designed to differ in physicochemical properties. Our study highlights specific surface area, elemental carbon content, PAHs and ROS-generating potential as physicochemical predictors of diesel particle toxicity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Diesel exhaust particles - ultrafine particles
- Exhaust gas recirculation
- Intratracheal instillation
- Renewable diesel fuels
- Toxicity
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Bendtsen, Katja ...
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Gren, Louise
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Malmborg, Vilhel ...
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Shukla, Pravesh ...
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Tunér, Martin
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Essig, Yona J.
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Krais, Annette M ...
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Clausen, Per Axe ...
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Berthing, Trine
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Loeschner, Katri ...
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Jacobsen, Nickla ...
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Wolff, Henrik
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Pagels, Joakim
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Vogel, Ulla Birg ...
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