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WFRF:(Bergh Thorén Fredrik 1976)
 

Search: WFRF:(Bergh Thorén Fredrik 1976) > Dynamics of myeloid...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004688naa a2200625 4500
001oai:gup.ub.gu.se/255800
003SwePub
008240528s2017 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2558002 URI
0247 a https://doi.org/10.1189/jlb.5VMA1116-455R2 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rydström, Anna,d 1976u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xrydsa
2451 0a Dynamics of myeloid cell populations during relapse-preventive immunotherapy in acute myeloid leukemia
264 1c 2017
520 a Relapse of leukemia in the postchemotherapy phase contributes to the poor prognosis and survival in patients with acute myeloid leukemia (AML). In an international phase IV trial (ClinicalTrials.gov; NCT01347996), 84 patients with AML in first complete remission who had not undergone transplantation received immunotherapy with histamine dihydrochloride (HDC) and low-dose IL-2 with the aim of preventing relapse. The dynamics of myeloid cell counts and expression of activation markers was assessed before and after cycles of immunotherapy and correlated with clinical outcome in terms of relapse risk and survival. During cycles, a pronounced increase in blood eosinophil counts was observed along with a reduction in monocyte and neutrophil counts. A strong reduction of blood monocyte counts during the first HDC/IL-2 treatment cycle predicted leukemia-free survival. The HDC component of the immunotherapy exerts agonist activity at histamine type 2 receptors (H2Rs) that are expressed by myeloid cells. It was observed that the density of H-2 R expression in blood monocytes increased during cycles of immunotherapy and that high monocyte H2R expression implied reduced relapse risk and improved overall survival. Several other activation markers, including HLA-DR, CD86, and CD40, were induced in monocytes and dendritic cells during immunotherapy but did not predict clinical outcome. In addition, expression of HLA-ABC increased in all myeloid populations during therapy. A low expression of HLA-ABC was associated with reduced relapse risk. These results suggest that aspects of myeloid cell biology may impact clinical benefit of relapse-preventive immunotherapy in AML.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a eosinophils
653 a monocytes
653 a dendritic cells
653 a H2R
653 a histamine dihydrochloride
653 a remission maintenance
653 a suppressor-cells
653 a nadph oxidase
653 a group-b
653 a interleukin-2
653 a cancer
653 a monocyte
653 a metaanalysis
653 a expression
653 a Cell Biology
653 a Hematology
653 a Immunology
653 a a r
653 a 1991
653 a british journal of haematology
653 a v77
653 a p491
7001 a Hallner, Alexander,d 1990u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xhaale
7001 a Aurelius, Johan,d 1980u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xaurjo
7001 a Sander, Frida Ewaldu Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut
7001 a Bernson, Elin,d 1987u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xberej
7001 a Kiffin, Robertau Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xkifro
7001 a Bergh Thorén, Fredrik,d 1976u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xthofr
7001 a Hellstrand, Kristoffer,d 1956u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xhellk
7001 a Martner, Anna,d 1979u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xbigan
7102 a Göteborgs universitetb Sahlgrenska Cancer Center4 org
7730 t Journal of Leukocyte Biologyg 102:2, s. 467-474q 102:2<467-474x 0741-5400
8564 8u https://gup.ub.gu.se/publication/255800
8564 8u https://doi.org/10.1189/jlb.5VMA1116-455R

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