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USF1 gene variants ...
USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study
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Auro, K. (författare)
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Kristiansson, K. (författare)
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- Zethelius, Björn (författare)
- Uppsala universitet,Geriatrik
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- Berne, Christian (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Diabetes och endokrinologi
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- Lannfelt, Lars (författare)
- Uppsala universitet,Geriatrik
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Taskinen, M-R. (författare)
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Jauhiainen, M. (författare)
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Perola, M. (författare)
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Peltonen, Leena (författare)
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- Syvänen, Ann-Christine (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- 2007-12-21
- 2008
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 51:3, s. 464-472
- Relaterad länk:
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS/HYPOTHESIS: Genetic variants of upstream transcription factor 1 (USF1) have previously been associated with dyslipidaemias in family studies. Our aim was to further address the role of USF1 in metabolic syndrome and cardiovascular traits at the population level in a large Swedish male cohort (n=2,322) with multiple measurements for risk factors during 32 years of follow-up. METHODS: Participants, born in 1920-1924, were examined at 50, 60, 70 and 77 years of age. The follow-up period for cardiovascular events was 1970-2002. We genotyped three haplotype tagging polymorphisms capturing the major allelic variants of USF1. RESULTS: SNP rs2774279 was associated with the metabolic syndrome. The minor allele of rs2774279 was less common among individuals with metabolic syndrome than among healthy controls [p=0.0029 when metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III; p=0.0073 when defined according to the International Diabetes Federation (IDF)]. The minor allele of rs2774279 was also associated with lower BMI, lower fasting glucose values and higher HDL-cholesterol concentrations in longitudinal analyses. With SNP rs2073658, a borderline association with metabolic syndrome was observed (p=0.036, IDF), the minor allele being the risk-increasing allele. The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses. Importantly, these trends with respect to the allelic variants prevailed throughout the follow-up time of three decades. CONCLUSIONS/INTERPRETATION: Our results suggest that USF1 variants associate with the metabolic syndrome at population level and influence the cardiovascular risk factors throughout adulthood in a consistent, longitudinal manner.
Nyckelord
- Cardiovascular diseases
- Epidemiology
- Genetics
- Lipids
- Metabolic syndrome
- Syndrome X
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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Auro, K.
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Kristiansson, K.
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Zethelius, Björn
-
Berne, Christian
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Lannfelt, Lars
-
Taskinen, M-R.
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visa fler...
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Jauhiainen, M.
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Perola, M.
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Peltonen, Leena
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Syvänen, Ann-Chr ...
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visa färre...
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Uppsala universitet