Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

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MARC

Fältnamn	Indikatorer	Metadata
000		05981naa a2201501 4500
001		oai:DiVA.org:oru-27404
003		SwePub
008		130206s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:121622686
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-274042 URI
024	7	a https://doi.org/10.1038/ng.7172 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1216226862 URI
040		a (SwePub)orud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Franke, Andre4 aut
245	1 0	a Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
264		c 2010-11-21
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a Medicine
653		a Medicin
700	1	a McGovern, Dermot P B4 aut
700	1	a Barrett, Jeffrey C4 aut
700	1	a Wang, Kai4 aut
700	1	a Radford-Smith, Graham L4 aut
700	1	a Ahmad, Tariq4 aut
700	1	a Lees, Charlie W4 aut
700	1	a Balschun, Tobias4 aut
700	1	a Lee, James4 aut
700	1	a Roberts, Rebecca4 aut
700	1	a Anderson, Carl A4 aut
700	1	a Bis, Joshua C4 aut
700	1	a Bumpstead, Suzanne4 aut
700	1	a Ellinghaus, David4 aut
700	1	a Festen, Eleonora M4 aut
700	1	a Georges, Michel4 aut
700	1	a Green, Todd4 aut
700	1	a Haritunians, Talin4 aut
700	1	a Jostins, Luke4 aut
700	1	a Latiano, Anna4 aut
700	1	a Mathew, Christopher G4 aut
700	1	a Montgomery, Grant W4 aut
700	1	a Prescott, Natalie J4 aut
700	1	a Raychaudhuri, Soumya4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Schumm, Philip4 aut
700	1	a Sharma, Yashoda4 aut
700	1	a Simms, Lisa A4 aut
700	1	a Taylor, Kent D4 aut
700	1	a Whiteman, David4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Baldassano, Robert N4 aut
700	1	a Barclay, Murray4 aut
700	1	a Bayless, Theodore M4 aut
700	1	a Brand, Stephan4 aut
700	1	a Büning, Carsten4 aut
700	1	a Cohen, Albert4 aut
700	1	a Colombel, Jean-Frederick4 aut
700	1	a Cottone, Mario4 aut
700	1	a Stronati, Laura4 aut
700	1	a Denson, Ted4 aut
700	1	a De Vos, Martine4 aut
700	1	a D'Inca, Renata4 aut
700	1	a Dubinsky, Marlau Karolinska Institutet4 aut
700	1	a Edwards, Cathryn4 aut
700	1	a Florin, Tim4 aut
700	1	a Franchimont, Denis4 aut
700	1	a Gearry, Richard4 aut
700	1	a Glas, Jürgen4 aut
700	1	a Van Gossum, Andre4 aut
700	1	a Guthery, Stephen L4 aut
700	1	a Halfvarson, Jonas,d 1970-u Örebro universitet,Hälsoakademin4 aut0 (Swepub:oru)jshn
700	1	a Verspaget, Hein W4 aut
700	1	a Hugot, Jean-Pierre4 aut
700	1	a Karban, Amir4 aut
700	1	a Laukens, Debby4 aut
700	1	a Lawrance, Ian4 aut
700	1	a Lemann, Marc4 aut
700	1	a Levine, Arie4 aut
700	1	a Libioulle, Cecile4 aut
700	1	a Louis, Edouard4 aut
700	1	a Mowat, Craig4 aut
700	1	a Newman, William4 aut
700	1	a Panés, Julián4 aut
700	1	a Phillips, Anne4 aut
700	1	a Proctor, Deborah D4 aut
700	1	a Regueiro, Miguel4 aut
700	1	a Russell, Richard4 aut
700	1	a Rutgeerts, Paul4 aut
700	1	a Sanderson, Jeremy4 aut
700	1	a Sans, Miquel4 aut
700	1	a Seibold, Frank4 aut
700	1	a Steinhart, A Hillary4 aut
700	1	a Stokkers, Pieter C F4 aut
700	1	a Torkvist, Leifu Karolinska Institutet4 aut
700	1	a Kullak-Ublick, Gerd4 aut
700	1	a Wilson, David4 aut
700	1	a Walters, Thomas4 aut
700	1	a Targan, Stephan R4 aut
700	1	a Brant, Steven R4 aut
700	1	a Rioux, John D4 aut
700	1	a D'Amato, Mauro4 aut
700	1	a Weersma, Rinse K4 aut
700	1	a Kugathasan, Subra4 aut
700	1	a Griffiths, Anne M4 aut
700	1	a Mansfield, John C4 aut
700	1	a Vermeire, Severine4 aut
700	1	a Duerr, Richard H4 aut
700	1	a Silverberg, Mark S4 aut
700	1	a Satsangi, Jack4 aut
700	1	a Schreiber, Stefan4 aut
700	1	a Cho, Judy H4 aut
700	1	a Annese, Vito4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Daly, Mark J4 aut
700	1	a Parkes, Miles4 aut
710	2	a Karolinska Institutetb Hälsoakademin4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:12, s. 1118-1125q 42:12<1118-1125x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3299551?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27404
856	4 8	u https://doi.org/10.1038/ng.717
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:121622686

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By the author/editor: Franke, Andre; McGovern, Dermot ...; Barrett, Jeffrey ...; Wang, Kai; Radford-Smith, G ...; Ahmad, Tariq; show more...; Lees, Charlie W; Balschun, Tobias; Lee, James; Roberts, Rebecca; Anderson, Carl A; Bis, Joshua C; Bumpstead, Suzan ...; Ellinghaus, Davi ...; Festen, Eleonora ...; Georges, Michel; Green, Todd; Haritunians, Tal ...; Jostins, Luke; Latiano, Anna; Mathew, Christop ...; Montgomery, Gran ...; Prescott, Natali ...; Raychaudhuri, So ...; Rotter, Jerome I; Schumm, Philip; Sharma, Yashoda; Simms, Lisa A; Taylor, Kent D; Whiteman, David; Wijmenga, Cisca; Baldassano, Robe ...; Barclay, Murray; Bayless, Theodor ...; Brand, Stephan; Büning, Carsten; Cohen, Albert; Colombel, Jean-F ...; Cottone, Mario; Stronati, Laura; Denson, Ted; De Vos, Martine; D'Inca, Renata; Dubinsky, Marla; Edwards, Cathryn; Florin, Tim; Franchimont, Den ...; Gearry, Richard; Glas, Jürgen; Van Gossum, Andr ...; Guthery, Stephen ...; Halfvarson, Jona ...; Verspaget, Hein ...; Hugot, Jean-Pier ...; Karban, Amir; Laukens, Debby; Lawrance, Ian; Lemann, Marc; Levine, Arie; Libioulle, Cecil ...; Louis, Edouard; Mowat, Craig; Newman, William; Panés, Julián; Phillips, Anne; Proctor, Deborah ...; Regueiro, Miguel; Russell, Richard; Rutgeerts, Paul; Sanderson, Jerem ...; Sans, Miquel; Seibold, Frank; Steinhart, A Hil ...; Stokkers, Pieter ...; Torkvist, Leif; Kullak-Ublick, G ...; Wilson, David; Walters, Thomas; Targan, Stephan ...; Brant, Steven R; Rioux, John D; D'Amato, Mauro; Weersma, Rinse K; Kugathasan, Subr ...; Griffiths, Anne ...; Mansfield, John ...; Vermeire, Severi ...; Duerr, Richard H; Silverberg, Mark ...; Satsangi, Jack; Schreiber, Stefa ...; Cho, Judy H; Annese, Vito; Hakonarson, Hako ...; Daly, Mark J; Parkes, Miles; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Nature Genetics

By the university: Örebro University; Karolinska Institutet

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