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Cerebrospinal fluid...
Cerebrospinal fluid cathepsin B and S
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- Nilsson, Elin (författare)
- Uppsala universitet,Biokemisk struktur och funktion,Klinisk kemi
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Bodolea, Constantin (författare)
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- Gordh, Torsten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (författare)
- Uppsala universitet,Biokemisk struktur och funktion,Klinisk kemi
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(creator_code:org_t)
- 2012-03-23
- 2013
- Engelska.
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Ingår i: Neurological Sciences. - : Springer Science and Business Media LLC. - 1590-1874 .- 1590-3478. ; 34:4, s. 445-448
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893–17,636 pg/mL for cathepsin B and 2,681–11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (ämneskategori)
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