Search: WFRF:(Braunbeck Thomas)
> (2005-2009) >
Activities and iden...
Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river
-
- Keiter, Steffen (author)
- University of Heidelberg, Heidelberg, Germany,MTM
-
- Grund, Stefanie (author)
- University of Heidelberg, Heidelberg, Germany
-
- van Bavel, Bert (author)
- Örebro universitet,Institutionen för naturvetenskap,MTM
-
show more...
-
- Hagberg, Jessika (author)
- Örebro universitet,Institutionen för naturvetenskap,MTM
-
- Engwall, Magnus (author)
- Örebro universitet,Institutionen för naturvetenskap,Bioanalytisk miljötoxikologi,MTM
-
- Kammann, Ulrike (author)
- Federal Research Centre for Fisheries, Hamburg, Germany
-
- Klempt, Martin (author)
- Federal Research Centre for Nutrition and Food, Hamburg, Germany
-
- Manz, Werner (author)
- Federal Institute of Hydrology, Koblenz, Germany
-
- Olsman Takner, Helena (author)
- Örebro universitet,Institutionen för naturvetenskap,Bioanalytisk miljötoxikologi,MTM
-
- Braunbeck, Thomas (author)
- University of Heidelberg, Heidelberg, Germany
-
- Hollert, Henner (author)
- RWTH Aachen University, Aachen, Germany
-
show less...
-
(creator_code:org_t)
- 2007-10-16
- 2008
- English.
-
In: Analytical and Bioanalytical Chemistry. - Berlin / Heidelberg : Springer. - 1618-2642 .- 1618-2650. ; 390:8, s. 2009-2019
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- This study is a consequence of a distinct fish decline in the Danube river since the beginning of the 1990s. In contrast to the decline of fish population, former studies have repeatedly documented that the water quality along the Danube river is improving. However, the conclusion of a pilot study in 2002 was that a high hazard potential is associated with local sediments. The present study documents that sediment samples from the Danube river showed comparatively high aryl hydrocarbon receptor mediated activity in biotests, using the cell lines GPC.2D.Luc, H4IIE (DR-CALUX®) and RTL-W1. The combination of chemical analysis, fractionation techniques and different in vitro tests revealed that priority pollutants could not explain the main induction, even though the concentrations of priority polycyclic aromatic hydrocarbons (PAHs) were very high (maximum in the tributary Schwarzach, sum of 16 EPA PAHs 26 μg/g). In conclusion, this investigation shows that nonpriority pollutants mainly mediate the high induction rates. Nevertheless, owing to the effects of PAHs towards fish and the connection between dioxin-like activity and carcinogenicity, the link between contamination and the fish population decline cannot be ruled out.
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Animals
- Benzofurans/analysis
- Biological Assay/methods
- Cell Line
- Cytochrome P-450 CYP1A1/drug effects
- Enzyme Induction/drug effects
- Geologic Sediments/*chemistry
- Germany
- Guinea Pigs
- Oncorhynchus mykiss
- Polychlorinated Biphenyls/analysis
- Polycyclic Hydrocarbons; Aromatic/*analysis
- Rats
- Receptors; Aryl Hydrocarbon/*agonists
- Reproducibility of Results
- Rivers
- Tetrachlorodibenzodioxin/analysis
- Water Pollutants; Chemical/*chemistry
- NATURAL SCIENCES
- NATURVETENSKAP
- Analytical chemistry
- Analytisk kemi
- Analytical Chemistry
- Analytisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Keiter, Steffen
-
Grund, Stefanie
-
van Bavel, Bert
-
Hagberg, Jessika
-
Engwall, Magnus
-
Kammann, Ulrike
-
show more...
-
Klempt, Martin
-
Manz, Werner
-
Olsman Takner, H ...
-
Braunbeck, Thoma ...
-
Hollert, Henner
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Analytical Chemi ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Earth and Relate ...
-
and Environmental Sc ...
- Articles in the publication
-
Analytical and B ...
- By the university
-
Örebro University