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Sex differences in associations between APOE ε2 and longitudinal cognitive decline
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- Wood, Madeline E. (author)
- University of Toronto,Sunnybrook Health Sciences Centre
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- Xiong, Lisa Y. (author)
- University of Toronto,Sunnybrook Health Sciences Centre
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- Wong, Yuen Yan (author)
- University of Toronto,Sunnybrook Health Sciences Centre
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- Buckley, Rachel F. (author)
- Melbourne School of Psychological Sciences,Harvard Medical School,University of Melbourne
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- Swardfager, Walter (author)
- Sunnybrook Health Sciences Centre,University of Toronto
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- Masellis, Mario (author)
- Sunnybrook Health Sciences Centre,University of Toronto
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- Lim, Andrew S.P. (author)
- University of Toronto,Sunnybrook Health Sciences Centre
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- Nichols, Emma (author)
- Johns Hopkins Bloomberg School of Public Health
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- Joie, Renaud La (author)
- University of California, San Francisco
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- Casaletto, Kaitlin B. (author)
- University of California, San Francisco
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- Kumar, Raj G. (author)
- Icahn School of Medicine at Mount Sinai
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- Dams-O'Connor, Kristen (author)
- Icahn School of Medicine at Mount Sinai
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- Palta, Priya (author)
- Columbia University
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- George, Kristen M. (author)
- University of California, Davis
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- Satizabal, Claudia L. (author)
- Boston University,University of Texas Health Science Centre
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- Barnes, Lisa L. (author)
- Rush Alzheimer's Disease Center
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- Schneider, Julie A. (author)
- Rush Alzheimer's Disease Center
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- Binet, Alexa Pichette (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Villeneuve, Sylvia (author)
- McConnell Brain Imaging Centre,McGill University
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- Pa, Judy (author)
- University of Southern California
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- Brickman, Adam M. (author)
- Columbia University
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- Black, Sandra E. (author)
- Sunnybrook Health Sciences Centre,University of Toronto
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- Rabin, Jennifer S. (author)
- University of Toronto,Sunnybrook Health Sciences Centre
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(creator_code:org_t)
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- 2023-03-30
- 2023
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:10, s. 4651-4661
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- APOE
- cognitive decline
- race/ethnicity
- sex differences
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wood, Madeline E ...
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Xiong, Lisa Y.
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Wong, Yuen Yan
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Buckley, Rachel ...
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Swardfager, Walt ...
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Masellis, Mario
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show more...
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Lim, Andrew S.P.
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Nichols, Emma
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Joie, Renaud La
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Casaletto, Kaitl ...
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Kumar, Raj G.
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Dams-O'Connor, K ...
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Palta, Priya
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George, Kristen ...
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Satizabal, Claud ...
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Barnes, Lisa L.
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Schneider, Julie ...
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Binet, Alexa Pic ...
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Villeneuve, Sylv ...
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Pa, Judy
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Brickman, Adam M ...
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Black, Sandra E.
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Rabin, Jennifer ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University