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Sökning: onr:"swepub:oai:DiVA.org:liu-190234" > Acute Myocarditis A...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007088naa a2200925 4500
001oai:DiVA.org:liu-190234
003SwePub
008221130s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1902342 URI
0247 a https://doi.org/10.1016/j.jchf.2022.06.0132 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ammirati, Enricou Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italy4 aut
2451 0a Acute Myocarditis Associated With Desmosomal Gene Variants
264 1b ELSEVIER SCI LTD,c 2022
338 a print2 rdacarrier
500 a Funding Agencies|Italian Ministry of Health [GR-2019-12368506]
520 a BACKGROUND The risk of adverse cardiovascular events in patients with acute myocarditis (AM) and desmosomal gene variants (DGV) remains unknown.OBJECTIVES The purpose of this study was to ascertain the risk of death, ventricular arrhythmias, recurrent myocarditis, and heart failure (main endpoint) in patients with AM and pathogenic or likely pathogenetic DGV.METHODS In a retrospective international study from 23 hospitals, 97 patients were included: 36 with AM and DGV (DGV[+]), 25 with AM and negative gene testing (DGV[-]), and 36 with AM without genetics testing. All patients had troponin elevation plus findings consistent with AM on histology or at cardiac magnetic resonance (CMR). In 86 patients, CMR changes in function and structure were re-assessed at follow-up.RESULTS In the DGV(+) AM group (88.9% DSP variants), median age was 24 years, 91.7% presented with chest pain, and median left ventricular ejection fraction (LVEF) was 56% on CMR (P = NS vs the other 2 groups). Kaplan-Meier curves demonstrated a higher risk of the main endpoint in DGV(+) AM compared with DGV(-) and without genetics testing patients (62.3% vs 17.5% vs 5.3% at 5 years, respectively; P < 0.0001), driven by myocarditis recurrence and ventricular arrhythmias. At follow-up CMR, a higher number of late gadolinium enhanced segments was found in DGV(+) AM. CONCLUSIONS Patients with AM and evidence of DGV have a higher incidence of adverse cardiovascular events compared with patients with AM without DGV. Further prospective studies are needed to ascertain if genetic testing might improve risk stratification of patients with AM who are considered at low risk. (J Am Coll Cardiol HF 2022;10:714-727) (c) 2022 by the American College of Cardiology Foundation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a cardiac magnetic resonance; desmoplakin; desmosomal gene variants; prognosis; acute myocarditis
7001 a Raimondi, Francescau M3C Hop Necker Enfants Malad, France4 aut
7001 a Piriou, Nicolasu Univ Nantes, France4 aut
7001 a Infirri, Loren Sardou Osped Circolo Varese, Italy4 aut
7001 a Mohiddin, Saidi A.u St Bartholomews Hosp, England4 aut
7001 a Mazzanti, Andreau IRCCS, Italy; Univ Pavia, Italy4 aut
7001 a Shenoy, Chetanu Univ Minnesota, MN USA4 aut
7001 a Cavallari, Ugo A.u Osped Niguarda Ca Granda, Italy4 aut
7001 a Imazio, Massimou Cardiothorac Dept, Italy4 aut
7001 a Aquaro, Giovanni Donatou Gabriele Monasterio Fdn, Italy4 aut
7001 a Olivotto, Iacopou Careggi Univ Hosp, Italy4 aut
7001 a Pedrotti, Patriziau Osped Niguarda Ca Granda, Italy4 aut
7001 a Sekhri, Nehau St Bartholomews Hosp, England4 aut
7001 a Heyning, Caroline M. Van deu Antwerp Univ Hosp, Belgium4 aut
7001 a Broeckx, Glennu Antwerp Univ Hosp, Belgium4 aut
7001 a Peretto, Giovanniu Univ Vita Salute San Raffaele, Italy4 aut
7001 a Guttmann, Oliveru St Bartholomews Hosp, England4 aut
7001 a Dellegrottaglie, Santou Clin Villa Fiori, Italy4 aut
7001 a Scatteia, Alessandrau Clin Villa Fiori, Italy4 aut
7001 a Gentile, Pierou Osped Niguarda Ca Granda, Italy4 aut
7001 a Merlo, Marcou Univ Trieste, Italy4 aut
7001 a Goldberg, Randal I.u NYU Langone Hlth, NY USA4 aut
7001 a Reyentovich, Alexu NYU Langone Hlth, NY USA4 aut
7001 a Sciamanna, Christopheru Univ Illinois, IL USA4 aut
7001 a Klaassen, Sabineu Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; Expt & Clin Res Ctr, Germany4 aut
7001 a Poller, Wolfgangu Corp Member Freie Universitdt Berlin & Humboldt Un, Germany; German Ctr Cardiovasc Res, Germany; Dept Cardiol, Germany4 aut
7001 a Trankle, Cory R.u Virginia Commonwealth Univ, VA USA4 aut
7001 a Abbate, Antoniou Virginia Commonwealth Univ, VA USA4 aut
7001 a Keren, Andreu Hadassah Hebrew Univ Med Ctr, Israel4 aut
7001 a Horowitz-Cederboim, Smadaru Hadassah Ctr Cardiogenet, Israel4 aut
7001 a Cadrin-Tourigny, Juliau Univ Montreal, Canada4 aut
7001 a Tadros, Rafiku Univ Montreal, Canada4 aut
7001 a Annoni, Giuseppe A.u Osped Niguarda Ca Granda, Italy4 aut
7001 a Bonoldi, Emanuelau Osped Niguarda Ca Granda, Italy4 aut
7001 a Toquet, Claireu Univ Nantes, France; Nantes Univ, France4 aut
7001 a Marteau, Larau Univ Nantes, France4 aut
7001 a Probst, Vincentu Univ Nantes, France4 aut
7001 a Trochu, Jean Noelu Univ Nantes, France4 aut
7001 a Kissopoulou, Antheiau Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten4 aut0 (Swepub:liu)n/a
7001 a Grosu, Aureliau Cardiovasc Dept, Italy4 aut
7001 a Kukavica, Deniu IRCCS, Italy; Univ Pavia, Italy4 aut
7001 a Trancuccio, Alessandrou IRCCS, Italy; Univ Pavia, Italy4 aut
7001 a Gil, Cristinau Univ Hosp Virgen Arrixaca, Spain; Univ Genoa, Italy4 aut
7001 a Pedrazzini, Matteou IRCCS Ist Auxol Italiano, Italy4 aut
7001 a Torchio, Margheritau IRCCS Ist Auxol Italiano, Italy4 aut
7001 a Sinagra, Gianfrancou Univ Trieste, Italy4 aut
7001 a Gimeno, Juan Ramonu Univ Hosp Virgen Arrixaca, Spain4 aut
7001 a Bernasconi, Davideu Univ Milano Bicocca, Italy4 aut
7001 a Valsecchi, Maria Graziau Univ Milano Bicocca, Italy4 aut
7001 a Klingel, Karinu Univ Hosp Tubingen, Germany4 aut
7001 a Adler, Eric D.u Univ Calif San Diego, CA USA4 aut
7001 a Camici, Paolo G.u Univ Vita Salute San Raffaele, Italy4 aut
7001 a Cooper, Leslie T.u Mayo Clin, FL USA; Mayo Clin Florida, FL 32224 USA4 aut
7102 a Osped Niguarda Ca Granda, Italy; Osped Niguarda Ca Granda, Italyb M3C Hop Necker Enfants Malad, France4 org
7730 t JACC. Heart failured : ELSEVIER SCI LTDg 10:10, s. 714-727q 10:10<714-727x 2213-1779x 2213-1787
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190234
8564 8u https://doi.org/10.1016/j.jchf.2022.06.013

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