Sökning: WFRF:(Campbell Ian) > (2010-2014) > New loci associated...
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000 | 07563naa a2201873 4500 | |
001 | oai:DiVA.org:uu-137787 | |
003 | SwePub | |
008 | 101215s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1377872 URI |
024 | 7 | a https://doi.org/10.1038/ng.5682 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Köttgen, Anna4 aut |
245 | 1 0 | a New loci associated with kidney function and chronic kidney disease |
264 | c 2010-04-11 | |
264 | 1 | b Springer Science and Business Media LLC,c 2010 |
338 | a print2 rdacarrier | |
520 | a Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci (P < 5 × 10−8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Pattaro, Cristian4 aut |
700 | 1 | a Böger, Carsten A.4 aut |
700 | 1 | a Fuchsberger, Christian4 aut |
700 | 1 | a Olden, Matthias4 aut |
700 | 1 | a Glazer, Nicole L.4 aut |
700 | 1 | a Parsa, Afshin4 aut |
700 | 1 | a Gao, Xiaoyi4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a O'Connell, Jeffrey R.4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a Schmidt, Helena4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Ketkar, Shamika4 aut |
700 | 1 | a Hwang, Shih-Jen4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Pare, Guillaume4 aut |
700 | 1 | a Atkinson, Elizabeth J.4 aut |
700 | 1 | a Zeller, Tanja4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a Cornelis, Marilyn C.4 aut |
700 | 1 | a Probst-Hensch, Nicole M.4 aut |
700 | 1 | a Kronenberg, Florian4 aut |
700 | 1 | a Toenjes, Anke4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Aspelund, Thor4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Rampersaud, Evadnie4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Arking, Dan E.4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Struchalin, Maksim4 aut |
700 | 1 | a Cavalieri, Margherita4 aut |
700 | 1 | a Singleton, Andrew4 aut |
700 | 1 | a Giallauria, Francesco4 aut |
700 | 1 | a Metter, Jeffrey4 aut |
700 | 1 | a de Boer, Ian H.4 aut |
700 | 1 | a Haritunians, Talin4 aut |
700 | 1 | a Lumley, Thomas4 aut |
700 | 1 | a Siscovick, David4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Zillikens, M. Carola4 aut |
700 | 1 | a Oostra, Ben A.4 aut |
700 | 1 | a Feitosa, Mary4 aut |
700 | 1 | a Province, Michael4 aut |
700 | 1 | a de Andrade, Mariza4 aut |
700 | 1 | a Turner, Stephen T.4 aut |
700 | 1 | a Schillert, Arne4 aut |
700 | 1 | a Ziegler, Andreas4 aut |
700 | 1 | a Wild, Philipp S.4 aut |
700 | 1 | a Schnabel, Renate B.4 aut |
700 | 1 | a Wilde, Sandra4 aut |
700 | 1 | a Munzel, Thomas4 aut |
700 | 1 | a Leak, Tennille S.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Meisinger, Christa4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Zgaga, Lina4 aut |
700 | 1 | a Zemunik, Tatijana4 aut |
700 | 1 | a Kolcic, Ivana4 aut |
700 | 1 | a Minelli, Cosetta4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Johansson, Åsau Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)asjoh108 |
700 | 1 | a Igl, Wilmaru Uppsala universitet,Institutionen för genetik och patologi4 aut |
700 | 1 | a Zaboli, Ghazalu Uppsala universitet,Institutionen för genetik och patologi4 aut |
700 | 1 | a Wild, Sarah H.4 aut |
700 | 1 | a Wright, Alan F.4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Ellinghaus, David4 aut |
700 | 1 | a Schreiber, Stefan4 aut |
700 | 1 | a Aulchenko, Yurii S.4 aut |
700 | 1 | a Felix, Janine F.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Imboden, Medea4 aut |
700 | 1 | a Nitsch, Dorothea4 aut |
700 | 1 | a Brandstaetter, Anita4 aut |
700 | 1 | a Kollerits, Barbara4 aut |
700 | 1 | a Kedenko, Lyudmyla4 aut |
700 | 1 | a Maegi, Reedik4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Kovacs, Peter4 aut |
700 | 1 | a Boban, Mladen4 aut |
700 | 1 | a Campbell, Susan4 aut |
700 | 1 | a Endlich, Karlhans4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Kroemer, Heyo K.4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Voelker, Uwe4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Badola, Sunita4 aut |
700 | 1 | a Parker, Alexander N.4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Kardia, Sharon L. R.4 aut |
700 | 1 | a Blankenberg, Stefan4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Curhan, Gary C.4 aut |
700 | 1 | a Franke, Andre4 aut |
700 | 1 | a Rochat, Thierry4 aut |
700 | 1 | a Paulweber, Bernhard4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Wang, Wei4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Coresh, Josef4 aut |
700 | 1 | a Schmidt, Reinhold4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Shlipak, Michael G.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Borecki, Ingrid4 aut |
700 | 1 | a Kraemer, Bernhard K.4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Wilson, James F.4 aut |
700 | 1 | a Witteman, Jacqueline C.4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Rettig, Rainer4 aut |
700 | 1 | a Hastie, Nick4 aut |
700 | 1 | a Chasman, Daniel I.4 aut |
700 | 1 | a Kao, W. H.4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 42:5, s. 376-384q 42:5<376-384x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc2997674?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-137787 |
856 | 4 8 | u https://doi.org/10.1038/ng.568 |
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