Novel genes and sex differences in COVID-19 severity

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Fältnamn	Indikatorer	Metadata
000		10890naa a2202377 4500
001		oai:DiVA.org:uu-514625
003		SwePub
008		231019s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:150508651
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5146252 URI
024	7	a https://doi.org/10.1093/hmg/ddac1322 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1505086512 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Cruz, Raquel4 aut
245	1 0	a Novel genes and sex differences in COVID-19 severity
264		c 2022-06-16
264	1	b Oxford University Press,c 2022
338		a electronic2 rdacarrier
520		a Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Diz-de Almeida, Silvia4 aut
700	1	a López de Heredia, Miguel4 aut
700	1	a Quintela, Inés4 aut
700	1	a Ceballos, Francisco C4 aut
700	1	a Pita, Guillermo4 aut
700	1	a Lorenzo-Salazar, José M4 aut
700	1	a González-Montelongo, Rafaela4 aut
700	1	a Gago-Domínguez, Manuela4 aut
700	1	a Sevilla Porras, Marta4 aut
700	1	a Tenorio Castaño, Jair Antonio4 aut
700	1	a Nevado, Julian4 aut
700	1	a Aguado, Jose María4 aut
700	1	a Aguilar, Carlos4 aut
700	1	a Aguilera-Albesa, Sergio4 aut
700	1	a Almadana, Virginia4 aut
700	1	a Almoguera, Berta4 aut
700	1	a Alvarez, Nuria4 aut
700	1	a Andreu-Bernabeu, Álvaro4 aut
700	1	a Arana-Arri, Eunate4 aut
700	1	a Arango, Celso4 aut
700	1	a Arranz, María J4 aut
700	1	a Artiga, Maria-Jesus4 aut
700	1	a Baptista-Rosas, Raúl C4 aut
700	1	a Barreda-Sánchez, María4 aut
700	1	a Belhassen-Garcia, Moncef4 aut
700	1	a Bezerra, Joao F4 aut
700	1	a Bezerra, Marcos A C4 aut
700	1	a Boix-Palop, Lucía4 aut
700	1	a Brion, María4 aut
700	1	a Brugada, Ramón4 aut
700	1	a Bustos, Matilde4 aut
700	1	a Calderón, Enrique J4 aut
700	1	a Carbonell, Cristina4 aut
700	1	a Castano, Luis4 aut
700	1	a Castelao, Jose E4 aut
700	1	a Conde-Vicente, Rosa4 aut
700	1	a Cordero-Lorenzana, M Lourdes4 aut
700	1	a Cortes-Sanchez, Jose L4 aut
700	1	a Corton, Marta4 aut
700	1	a Darnaude, M Teresa4 aut
700	1	a De Martino-Rodríguez, Alba4 aut
700	1	a Del Campo-Pérez, Victor4 aut
700	1	a Diaz de Bustamante, Aranzazu4 aut
700	1	a Domínguez-Garrido, Elena4 aut
700	1	a Luchessi, Andre D4 aut
700	1	a Eiros, Rocío4 aut
700	1	a Estigarribia Sanabria, Gladys Mercedes4 aut
700	1	a Carmen Fariñas, María4 aut
700	1	a Fernández-Robelo, Uxía4 aut
700	1	a Fernández-Rodríguez, Amanda4 aut
700	1	a Fernández-Villa, Tania4 aut
700	1	a Gil-Fournier, Belén4 aut
700	1	a Gómez-Arrue, Javier4 aut
700	1	a González Álvarez, Beatriz4 aut
700	1	a Gonzalez Bernaldo de Quirós, Fernan4 aut
700	1	a González-Peñas, Javier4 aut
700	1	a Gutiérrez-Bautista, Juan F4 aut
700	1	a Herrero, María José4 aut
700	1	a Herrero-Gonzalez, Antonio4 aut
700	1	a Jimenez-Sousa, María A4 aut
700	1	a Lattig, María Claudia4 aut
700	1	a Liger Borja, Anabel4 aut
700	1	a Lopez-Rodriguez, Rosario4 aut
700	1	a Mancebo, Estheru Karolinska Institutet4 aut
700	1	a Martín-López, Caridad4 aut
700	1	a Martín, Vicente4 aut
700	1	a Martinez-Nieto, Oscar4 aut
700	1	a Martinez-Lopez, Iciar4 aut
700	1	a Martinez-Resendez, Michel F4 aut
700	1	a Martinez-Perez, Angel4 aut
700	1	a Mazzeu, Juliana F4 aut
700	1	a Merayo Macías, Eleuterio4 aut
700	1	a Minguez, Pablo4 aut
700	1	a Moreno Cuerda, Victor4 aut
700	1	a Silbiger, Vivian N4 aut
700	1	a Oliveira, Silviene F4 aut
700	1	a Ortega-Paino, Eva4 aut
700	1	a Parellada, Mara4 aut
700	1	a Paz-Artal, Estela4 aut
700	1	a Santos, Ney P C4 aut
700	1	a Pérez-Matute, Patricia4 aut
700	1	a Perez, Patricia4 aut
700	1	a Pérez-Tomás, M Elena4 aut
700	1	a Perucho, Teresa4 aut
700	1	a Pinsach-Abuin, Mel Lina4 aut
700	1	a Pompa-Mera, Ericka N4 aut
700	1	a Porras-Hurtado, Gloria L4 aut
700	1	a Pujol, Aurora4 aut
700	1	a Ramiro León, Soraya4 aut
700	1	a Resino, Salvador4 aut
700	1	a Fernandes, Marianne R4 aut
700	1	a Rodríguez-Ruiz, Emilio4 aut
700	1	a Rodriguez-Artalejo, Fernando4 aut
700	1	a Rodriguez-Garcia, José A4 aut
700	1	a Ruiz Cabello, Francisco4 aut
700	1	a Ruiz-Hornillos, Javier4 aut
700	1	a Ryan, Pablo4 aut
700	1	a Soria, José Manuel4 aut
700	1	a Souto, Juan Carlos4 aut
700	1	a Tamayo, Eduardo4 aut
700	1	a Tamayo-Velasco, Alvaro4 aut
700	1	a Taracido-Fernandez, Juan Carlos4 aut
700	1	a Teper, Alejandro4 aut
700	1	a Torres-Tobar, Lilian4 aut
700	1	a Urioste, Miguel4 aut
700	1	a Valencia-Ramos, Juan4 aut
700	1	a Yáñez, Zuleima4 aut
700	1	a Zarate, Ruth4 aut
700	1	a Nakanishi, Tomoko4 aut
700	1	a Pigazzini, Sara4 aut
700	1	a Degenhardt, Frauke4 aut
700	1	a Butler-Laporte, Guillaume4 aut
700	1	a Maya-Miles, Douglas4 aut
700	1	a Bujanda, Luis4 aut
700	1	a Bouysran, Youssef4 aut
700	1	a Palom, Adriana4 aut
700	1	a Ellinghaus, David4 aut
700	1	a Martínez-Bueno, Manuel4 aut
700	1	a Rolker, Selina4 aut
700	1	a Amitrano, Sara4 aut
700	1	a Roade, Luisa4 aut
700	1	a Fava, Francesca4 aut
700	1	a Spinner, Christoph D4 aut
700	1	a Prati, Daniele4 aut
700	1	a Bernardo, David4 aut
700	1	a Garcia, Federico4 aut
700	1	a Darcis, Gilles4 aut
700	1	a Fernández-Cadenas, Israel4 aut
700	1	a Holter, Jan Cato4 aut
700	1	a Banales, Jesus M4 aut
700	1	a Frithiof, Robertu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)robfr118
700	1	a Duga, Stefano4 aut
700	1	a Asselta, Rosanna4 aut
700	1	a Pereira, Alexandre C4 aut
700	1	a Romero-Gómez, Manuel4 aut
700	1	a Nafría-Jiménez, Beatriz4 aut
700	1	a Hov, Johannes R4 aut
700	1	a Migeotte, Isabelle4 aut
700	1	a Renieri, Alessandra4 aut
700	1	a Planas, Anna M4 aut
700	1	a Ludwig, Kerstin U4 aut
700	1	a Buti, Maria4 aut
700	1	a Rahmouni, Souad4 aut
700	1	a Alarcón-Riquelme, Marta E4 aut
700	1	a Schulte, Eva C4 aut
700	1	a Franke, Andre4 aut
700	1	a Karlsen, Tom H4 aut
700	1	a Valenti, Luca4 aut
700	1	a Zeberg, Hugou Karolinska Institutet4 aut
700	1	a Richards, Brent4 aut
700	1	a Ganna, Andrea4 aut
700	1	a Boada, Mercè4 aut
700	1	a de Rojas, Itziar4 aut
700	1	a Ruiz, Agustín4 aut
700	1	a Sánchez-Juan, Pascual4 aut
700	1	a Real, Luis Miguel4 aut
700	1	a Guillen-Navarro, Encarna4 aut
700	1	a Ayuso, Carmen4 aut
700	1	a González-Neira, Anna4 aut
700	1	a Riancho, José A4 aut
700	1	a Rojas-Martinez, Augusto4 aut
700	1	a Flores, Carlos4 aut
700	1	a Lapunzina, Pablo4 aut
700	1	a Carracedo, Angel4 aut
700	1	a Lorenzo-Salazar, GM4 aut
710	2	a Karolinska Institutetb Anestesiologi och intensivvård4 org
773	0	t Human Molecular Geneticsd : Oxford University Pressg 31:22, s. 3789-3806q 31:22<3789-3806x 0964-6906x 1460-2083
856	4	u https://doi.org/10.1093/hmg/ddac132y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1806010/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-514625
856	4 8	u https://doi.org/10.1093/hmg/ddac132
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:150508651

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Av författaren/redakt...: Cruz, Raquel; Diz-de Almeida, ...; López de Heredia ...; Quintela, Inés; Ceballos, Franci ...; Pita, Guillermo; visa fler...; Lorenzo-Salazar, ...; González-Montelo ...; Gago-Domínguez, ...; Sevilla Porras, ...; Tenorio Castaño, ...; Nevado, Julian; Aguado, Jose Mar ...; Aguilar, Carlos; Aguilera-Albesa, ...; Almadana, Virgin ...; Almoguera, Berta; Alvarez, Nuria; Andreu-Bernabeu, ...; Arana-Arri, Euna ...; Arango, Celso; Arranz, María J; Artiga, Maria-Je ...; Baptista-Rosas, ...; Barreda-Sánchez, ...; Belhassen-Garcia ...; Bezerra, Joao F; Bezerra, Marcos ...; Boix-Palop, Lucí ...; Brion, María; Brugada, Ramón; Bustos, Matilde; Calderón, Enriqu ...; Carbonell, Crist ...; Castano, Luis; Castelao, Jose E; Conde-Vicente, R ...; Cordero-Lorenzan ...; Cortes-Sanchez, ...; Corton, Marta; Darnaude, M Tere ...; De Martino-Rodrí ...; Del Campo-Pérez, ...; Diaz de Bustaman ...; Domínguez-Garrid ...; Luchessi, Andre ...; Eiros, Rocío; Estigarribia San ...; Carmen Fariñas, ...; Fernández-Robelo ...; Fernández-Rodríg ...; Fernández-Villa, ...; Gil-Fournier, Be ...; Gómez-Arrue, Jav ...; González Álvarez ...; Gonzalez Bernald ...; González-Peñas, ...; Gutiérrez-Bautis ...; Herrero, María J ...; Herrero-Gonzalez ...; Jimenez-Sousa, M ...; Lattig, María Cl ...; Liger Borja, Ana ...; Lopez-Rodriguez, ...; Mancebo, Esther; Martín-López, Ca ...; Martín, Vicente; Martinez-Nieto, ...; Martinez-Lopez, ...; Martinez-Resende ...; Martinez-Perez, ...; Mazzeu, Juliana ...; Merayo Macías, E ...; Minguez, Pablo; Moreno Cuerda, V ...; Silbiger, Vivian ...; Oliveira, Silvie ...; Ortega-Paino, Ev ...; Parellada, Mara; Paz-Artal, Estel ...; Santos, Ney P C; Pérez-Matute, Pa ...; Perez, Patricia; Pérez-Tomás, M E ...; Perucho, Teresa; Pinsach-Abuin, M ...; Pompa-Mera, Eric ...; Porras-Hurtado, ...; Pujol, Aurora; Ramiro León, Sor ...; Resino, Salvador; Fernandes, Maria ...; Rodríguez-Ruiz, ...; Rodriguez-Artale ...; Rodriguez-Garcia ...; Ruiz Cabello, Fr ...; Ruiz-Hornillos, ...; Ryan, Pablo; Soria, José Manu ...; Souto, Juan Carl ...; Tamayo, Eduardo; Tamayo-Velasco, ...; Taracido-Fernand ...; Teper, Alejandro; Torres-Tobar, Li ...; Urioste, Miguel; Valencia-Ramos, ...; Yáñez, Zuleima; Zarate, Ruth; Nakanishi, Tomok ...; Pigazzini, Sara; Degenhardt, Frau ...; Butler-Laporte, ...; Maya-Miles, Doug ...; Bujanda, Luis; Bouysran, Yousse ...; Palom, Adriana; Ellinghaus, Davi ...; Martínez-Bueno, ...; Rolker, Selina; Amitrano, Sara; Roade, Luisa; Fava, Francesca; Spinner, Christo ...; Prati, Daniele; Bernardo, David; Garcia, Federico; Darcis, Gilles; Fernández-Cadena ...; Holter, Jan Cato; Banales, Jesus M; Frithiof, Robert; Duga, Stefano; Asselta, Rosanna; Pereira, Alexand ...; Romero-Gómez, Ma ...; Nafría-Jiménez, ...; Hov, Johannes R; Migeotte, Isabel ...; Renieri, Alessan ...; Planas, Anna M; Ludwig, Kerstin ...; Buti, Maria; Rahmouni, Souad; Alarcón-Riquelme ...; Schulte, Eva C; Franke, Andre; Karlsen, Tom H; Valenti, Luca; Zeberg, Hugo; Richards, Brent; Ganna, Andrea; Boada, Mercè; de Rojas, Itziar; Ruiz, Agustín; Sánchez-Juan, Pa ...; Real, Luis Migue ...; Guillen-Navarro, ...; Ayuso, Carmen; González-Neira, ...; Riancho, José A; Rojas-Martinez, ...; Flores, Carlos; Lapunzina, Pablo; Carracedo, Angel; Lorenzo-Salazar, ...; visa färre...

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