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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03996naa a2200457 4500 | |
| 001 | oai:DiVA.org:uu-194751 | |
| 003 | SwePub | |
| 008 | 130219s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1947512 URI |
| 024 | 7 | a https://doi.org/10.1152/ajpendo.00149.20122 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Shum, Michael4 aut |
| 245 | 1 0 | a Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats |
| 264 | 1 | b American Physiological Society,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats. Am J Physiol Endocrinol Metab 304: E197-E210, 2013. First published November 13, 2012; doi:10.1152/ajpendo.00149.2012.-This study was aimed at establishing whether specific activation of angiotensin II (ANG II) type 2 receptor (AT2R) modulates adipocyte differentiation and function. In primary cultures of subcutaneous (SC) and retroperitoneal (RET) preadipocytes, both AT2R and AT1R were expressed at the mRNA and protein level. Cells were stimulated with ANG II or the AT2R agonist C21/M24, alone or in the presence of the AT1R antagonist losartan or the AT2R antagonist PD123,319. During differentiation, C21/M24 increased PPA gamma expression in both RET and SC preadipocytes while the number of small lipid droplets and lipid accumulation solely increased in SC preadipocytes. In mature adipocytes, C21/M24 decreased the mean size of large lipid droplets. Upon abolishment of AT2R expression using AT2R-targeted shRNAs, expressions of AT2R, aP2, and PPAR gamma remained very low, and cells were unable to differentiate. In Wistar rats fed a 6-wk high-fat/high-fructose (HFHF) diet, a significant shift toward larger adipocytes was observed in RET and SC adipose tissue depots. C21/M24 treatments for 6 wk restored normal adipocyte size distribution in both these tissue depots. Moreover, C21/M24 and losartan decreased hyperinsulinemia and improved insulin sensitivity impaired by HFHF diet. A strong correlation between adipocyte size area and glucose infusion rate during euglycemic-hyperinsulinemic clamp was observed. These results indicate that AT2R is involved in early adipocyte differentiation, while in mature adipocytes and in a model of insulin resistance AT2R activation restores normal adipocyte morphology and improves insulin sensitivity. | |
| 653 | a angiotensin type 2 receptor | |
| 653 | a adipocyte | |
| 653 | a differentiation | |
| 653 | a PPAR gamma | |
| 653 | a high-fat/high-fructose diet | |
| 700 | 1 | a Pinard, Sandra4 aut |
| 700 | 1 | a Guimond, Marie-Odile4 aut |
| 700 | 1 | a Labbe, Sebastien M.4 aut |
| 700 | 1 | a Roberge, Claude4 aut |
| 700 | 1 | a Baillargeon, Jean-Patrice4 aut |
| 700 | 1 | a Langlois, Marie-France4 aut |
| 700 | 1 | a Alterman, Mathiasu Uppsala universitet,Avdelningen för organisk farmaceutisk kemi4 aut0 (Swepub:uu)mathialt |
| 700 | 1 | a Wallinder, Charlottau Uppsala universitet,Avdelningen för organisk farmaceutisk kemi4 aut0 (Swepub:uu)chwal103 |
| 700 | 1 | a Hallberg, Andersu Uppsala universitet,Avdelningen för organisk farmaceutisk kemi4 aut0 (Swepub:uu)andehall |
| 700 | 1 | a Carpentier, Andre C.4 aut |
| 700 | 1 | a Gallo-Payet, Nicole4 aut |
| 710 | 2 | a Uppsala universitetb Avdelningen för organisk farmaceutisk kemi4 org |
| 773 | 0 | t American Journal of Physiology. Endocrinology and Metabolismd : American Physiological Societyg 304:2, s. E197-E210q 304:2<E197-E210x 0193-1849x 1522-1555 |
| 856 | 4 | u https://europepmc.org/articles/pmc3543572 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194751 |
| 856 | 4 8 | u https://doi.org/10.1152/ajpendo.00149.2012 |
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